Atom economical synthesis of oxindoles by metal-catalyzed intramolecular C–C bond formation under solvent-free and aerobic conditions

2015 ◽  
Vol 17 (6) ◽  
pp. 3306-3309 ◽  
Author(s):  
Se In Son ◽  
Won Koo Lee ◽  
Jieun Choi ◽  
Hyun-Joon Ha
Keyword(s):  
Bond Formation ◽  
Solvent Free ◽  
Metal Salts ◽  
Aerobic Conditions ◽  
Metal Catalyzed ◽  
Bond Formation Reactions

Diversely substituted oxindoles were obtained from atom economical direct C–C bond formation reactions of various substituted anilides and pyridinylamides with metal salts and oxides.

Recent Developments in the Synthesis of Cinnoline Derivatives

2019 ◽  
Vol 16 (6) ◽  
pp. 578-588 ◽  
Author(s):  
Kamal Usef Sadek ◽  
Ramadan Ahmed Mekheimer ◽  
Mohamed Abd-Elmonem
Keyword(s):  
Reaction Mechanisms ◽  
Biological Activities ◽  
Bond Formation ◽  
Pharmaceutical Chemistry ◽  
Recent Developments ◽  
Synthetic Routes ◽  
Anti Inflammatory ◽  
Arenediazonium Salts ◽  
Metal Catalyzed ◽  
Bond Formation Reactions

Crinnolines can serve as unique and versatile class of heterocycles especially in fields related to synthetic and pharmaceutical chemistry owing to their potent biological activities. They possess diversity of pharmaceutical activities as anticancer, antibacterial, anti-inflammatory, anti-allergic as well as anti-hypertensive activities. Since the first synthesis of cinnoline by Richter (1883) numerous protocols for their synthesis have been developed utilizing arenediazonium salts, aryl hydrazines and arylhydhydrazones precursors. Recently metal catalyzed C-C and C-N bond formation reactions have emerged as efficient tools for synthesis of cinnoline derivatives. This review aims to focus on the recent synthetic routes used for the synthesis of cinnoline derivatives. An effort has been carried out to provide an overview of practical methods for preparing cinnolines. Furthermore the reaction mechanisms have been described in brief.

scholarly journals Halo-substituted benzenesulfonyls and benzenesulfinates: convenient sources of arenes in metal-catalyzed C–C bond formation reactions for the straightforward access to halo-substituted arenes

2018 ◽  
Vol 16 (24) ◽  
pp. 4399-4423 ◽  
Author(s):  
Haoran Li ◽  
Arpan Sasmal ◽  
Xinzhe Shi ◽  
Jean-François Soulé ◽  
Henri Doucet
Keyword(s):  
Bond Formation ◽  
Metal Catalyzed ◽  
Bond Formation Reactions

The use of halo-substituted ArSO2R as an aryl source in metal-catalyzed C–C bond formation reactions presents several advantages, as the reaction often proceeds without cleavage of the C–halo bonds.

Sign in / Sign up

Export Citation Format

Share Document