Metal-Catalyzed C—S Bond Formation Reactions

2008 ◽  
pp. 1
Author(s):  
A. Polo ◽  
J. Real
Keyword(s):  
Bond Formation ◽  
Metal Catalyzed ◽  
Bond Formation Reactions

Atom economical synthesis of oxindoles by metal-catalyzed intramolecular C–C bond formation under solvent-free and aerobic conditions

2015 ◽  
Vol 17 (6) ◽  
pp. 3306-3309 ◽  
Author(s):  
Se In Son ◽  
Won Koo Lee ◽  
Jieun Choi ◽  
Hyun-Joon Ha
Keyword(s):  
Bond Formation ◽  
Solvent Free ◽  
Metal Salts ◽  
Aerobic Conditions ◽  
Metal Catalyzed ◽  
Bond Formation Reactions

Diversely substituted oxindoles were obtained from atom economical direct C–C bond formation reactions of various substituted anilides and pyridinylamides with metal salts and oxides.

Recent Developments in the Synthesis of Cinnoline Derivatives

2019 ◽  
Vol 16 (6) ◽  
pp. 578-588 ◽  
Author(s):  
Kamal Usef Sadek ◽  
Ramadan Ahmed Mekheimer ◽  
Mohamed Abd-Elmonem
Keyword(s):  
Reaction Mechanisms ◽  
Biological Activities ◽  
Bond Formation ◽  
Pharmaceutical Chemistry ◽  
Recent Developments ◽  
Synthetic Routes ◽  
Anti Inflammatory ◽  
Arenediazonium Salts ◽  
Metal Catalyzed ◽  
Bond Formation Reactions

Crinnolines can serve as unique and versatile class of heterocycles especially in fields related to synthetic and pharmaceutical chemistry owing to their potent biological activities. They possess diversity of pharmaceutical activities as anticancer, antibacterial, anti-inflammatory, anti-allergic as well as anti-hypertensive activities. Since the first synthesis of cinnoline by Richter (1883) numerous protocols for their synthesis have been developed utilizing arenediazonium salts, aryl hydrazines and arylhydhydrazones precursors. Recently metal catalyzed C-C and C-N bond formation reactions have emerged as efficient tools for synthesis of cinnoline derivatives. This review aims to focus on the recent synthetic routes used for the synthesis of cinnoline derivatives. An effort has been carried out to provide an overview of practical methods for preparing cinnolines. Furthermore the reaction mechanisms have been described in brief.

scholarly journals Halo-substituted benzenesulfonyls and benzenesulfinates: convenient sources of arenes in metal-catalyzed C–C bond formation reactions for the straightforward access to halo-substituted arenes

2018 ◽  
Vol 16 (24) ◽  
pp. 4399-4423 ◽  
Author(s):  
Haoran Li ◽  
Arpan Sasmal ◽  
Xinzhe Shi ◽  
Jean-François Soulé ◽  
Henri Doucet
Keyword(s):  
Bond Formation ◽  
Metal Catalyzed ◽  
Bond Formation Reactions

The use of halo-substituted ArSO2R as an aryl source in metal-catalyzed C–C bond formation reactions presents several advantages, as the reaction often proceeds without cleavage of the C–halo bonds.

Carbon-carbon bond-forming reactions using alkyl fluorides

2008 ◽  
Vol 80 (5) ◽  
pp. 941-951 ◽  
Author(s):  
Jun Terao ◽  
Hirohisa Todo ◽  
Hiroyasu Watabe ◽  
Aki Ikumi ◽  
Yoshiaki Shinohara ◽  
...  
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Transition Metal Catalysts ◽  
Grignard Reagents ◽  
Bond Forming ◽  
Carbon Carbon Bond ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Alkyl Fluorides ◽  
Bond Formation Reactions

This account reviews C-C bond formation reactions using alkyl fluorides mostly focusing on the transition-metal-catalyzed reactions. These reactions proceed efficiently under mild conditions by the combined use of Grignard reagents and transition-metal catalysts, such as Ni, Cu, and Zr. It is proposed that ate complex intermediates formed by the reaction of these transition metals with Grignard reagents play important roles as the active catalytic species. Organoaluminun reagents react directly with alkyl fluorides in nonpolar solvents at room temperature to form C-C bonds. These studies demonstrate the practical usefulness of alkyl fluorides in C-C bond formation reactions and provide a promising method for the construction of carbon frameworks employing alkyl fluorides. The scope and limitations, as well as reaction pathways, are discussed.

Transition-metal catalysed C–N bond activation

2016 ◽  
Vol 45 (5) ◽  
pp. 1257-1272 ◽  
Author(s):  
Quanjun Wang ◽  
Yijin Su ◽  
Lixin Li ◽  
Hanmin Huang
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Bond Formation ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Bond Formation Reactions

Efficient strategies for transition-metal catalyzed C–N bond activation and their applications in new C–X bond formation reactions are summarized.

Carbon Dioxide-Mediated C(sp2)–H Arylation of Primary and Secondary Benzylamines

2018 ◽  
Author(s):  
Mohit Kapoor ◽  
Pratibha Chand-Thakuri ◽  
Michael Young
Keyword(s):  
Carbon Dioxide ◽  
Transition Metal ◽  
Bond Activation ◽  
Bond Formation ◽  
Carbon Bond ◽  
Chelate Effect ◽  
Free Amine ◽  
Carbon Carbon Bond ◽  
New Strategy ◽  
Metal Catalyzed

Carbon-carbon bond formation by transition metal-catalyzed C–H activation has become an important strategy to fabricate new bonds in a rapid fashion. Despite the pharmacological importance of <i>ortho</i>-arylbenzylamines, however, effective <i>ortho</i>-C–C bond formation from C–H bond activation of free primary and secondary benzylamines using Pd<sup>II</sup> remains an outstanding challenge. Presented herein is a new strategy for constructing <i>ortho</i>-arylated primary and secondary benzylamines mediated by carbon dioxide (CO<sub>2</sub>). The use of CO<sub>2</sub> is critical to allowing this transformation to proceed under milder conditions than previously reported, and that are necessary to furnish free amine products that can be directly used or elaborated without the need for deprotection. In cases where diarylation is possible, a chelate effect is demonstrated to facilitate selective monoarylation.

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