Design and synthesis of periodic mesoporous organosilica materials with a multi-compartment structure

RSC Advances ◽  
2015 ◽  
Vol 5 (109) ◽  
pp. 89397-89406 ◽  
Author(s):  
Chun Xiang Cynthia Lin ◽  
Siddharth Jambhrunkar ◽  
Pei Yuan ◽  
Chun Hui Clayton Zhou ◽  
George Xiu Song Zhao
Keyword(s):  
Anticancer Drug ◽  
Release Rate ◽  
Slow Release ◽  
Drug Carrier ◽  
High Loading ◽  
Loading Capacity ◽  
Periodic Mesoporous Organosilica ◽  
Design And Synthesis ◽  
Mesoporous Organosilica ◽  
Organosilica Materials

Multi-compartment periodic mesoporous organosilica materials show desirable properties as anticancer drug carrier with high loading capacity and slow release rate.

scholarly journals Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

2017 ◽  
Vol 8 ◽  
pp. 1457-1468 ◽  
Author(s):  
Gamze Varan ◽  
Juan M Benito ◽  
Carmen Ortiz Mellet ◽  
Erem Bilensoy
Keyword(s):  
Drug Delivery ◽  
Cell Line ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Delivery Systems ◽  
Loading Capacity ◽  
Promising Alternative ◽  
Cytotoxicity Studies ◽  
Amphiphilic Cyclodextrin

Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its bioavailability problems arising from very poor aqueous solubility and tendency to recrystallize upon dilution, paclitaxel is commercially formulated with co-solvents such as Cremophor EL® that are known to cause serious side effects during chemotherapy. Amphiphilic cyclodextrins are favored oligosaccharides as drug delivery systems for anticancer drugs, having the ability to spontaneously form nanoparticles without surfactant or co-solvents. In the past few years, polycationic, amphiphilic cyclodextrins were introduced as effective agents for gene delivery in the form of nanoplexes. In this study, the potential of polycationic, amphiphilic cyclodextrin nanoparticles were evaluated in comparison to non-ionic amphiphilic cyclodextrins and core–shell type cyclodextrin nanoparticles for paclitaxel delivery to breast tumors. Pre-formulation studies were used as a basis for selecting the suitable organic solvent and surfactant concentration for the novel polycationic cyclodextrin nanoparticles. The nanoparticles were then extensively characterized with particle size distribution, polydispersity index, zeta potential, drug loading capacity, in vitro release profiles and cytotoxicity studies. Results: Paclitaxel-loaded cyclodextrin nanoparticles were obtained in the diameter range of 80−125 nm (depending on the nature of the cyclodextrin derivative) where the smallest diameter nanoparticles were obtained with polycationic (PC) βCDC6. A strong positive charge also helped to increase the loading capacity of the nanoparticles with paclitaxel up to 60%. Interestingly, cyclodextrin nanoparticles were able to stabilize paclitaxel in aqueous solution for 30 days. All blank cyclodextrin nanoparticles were demonstrated to be non-cytotoxic against L929 mouse fibroblast cell line. In addition, paclitaxel-loaded nanoparticles have a significant anticancer effect against MCF-7 human breast cancer cell line as compared with a paclitaxel solution in DMSO. Conclusion: According to the results of this study, both amphiphilic cyclodextrin derivatives provide suitable nanometer-sized drug delivery systems for safe and efficient intravenous paclitaxel delivery for chemotherapy. In the light of these studies, it can be said that amphiphilic cyclodextrin nanoparticles of different surface charge can be considered as a promising alternative for self-assembled nanometer-sized drug carrier systems for safe and efficient chemotherapy.

Periodic Mesoporous Organosilica Materials: Self-Assembly of Carbamothioic Acid-Bridged Organosilane Precursors

2009 ◽  
Vol 15 (33) ◽  
pp. 8310-8318 ◽  
Author(s):  
Ling Gao ◽  
Feng Wei ◽  
Yu Zhou ◽  
Xiao Xing Fan ◽  
Ying Wang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica ◽  
Organosilica Materials

Novel wrinkled periodic mesoporous organosilica nanoparticles for hydrophobic anticancer drug delivery

2014 ◽  
Vol 22 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Imalka Munaweera ◽  
Jessica Hong ◽  
Alicia D’Souza ◽  
Kenneth J. Balkus
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Periodic Mesoporous Organosilica ◽  
Anticancer Drug Delivery ◽  
Mesoporous Organosilica

Recent advances in hybrid periodic mesostructured organosilica materials: opportunities from fundamental to biomedical applications

RSC Advances ◽  
2015 ◽  
Vol 5 (96) ◽  
pp. 79129-79151 ◽  
Author(s):  
Mohammad A. Wahab ◽  
Jorge N. Beltramini
Keyword(s):  
Functional Groups ◽  
Biomedical Applications ◽  
Periodic Mesoporous Organosilica ◽  
Recent Advances ◽  
Mesoporous Organosilica ◽  
Organosilica Materials

Periodic mesoporous organosilica nanostructures functionalized with various active functional groups: from design to biomedical applications.

Periodic mesoporous organosilica materials as sorbents for solid-phase extraction of drugs prior to simultaneous enantiomeric separation by capillary electrophoresis

2018 ◽  
Vol 1566 ◽  
pp. 135-145 ◽  
Author(s):  
Jesús Valimaña-Traverso ◽  
Sonia Morante-Zarcero ◽  
Damián Pérez-Quintanilla ◽  
María Ángeles García ◽  
Isabel Sierra ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Enantiomeric Separation ◽  
Phase Extraction ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica ◽  
Organosilica Materials

Transformable periodic mesoporous organosilica materials

2010 ◽  
Vol 46 (12) ◽  
pp. 2100 ◽  
Author(s):  
Steven E. Dickson ◽  
Cathleen M. Crudden
Keyword(s):  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica ◽  
Organosilica Materials
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