Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension

2013 ◽  
Vol 23 (21) ◽  
pp. 5975-5979 ◽  
Author(s):  
Yuko Kato ◽  
Nobuhiro Fuchi ◽  
Hajime Saburi ◽  
Yutaka Nishimura ◽  
Ayano Watanabe ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Active Drug ◽  
Soluble Epoxide Hydrolase ◽  
Urea Derivatives ◽  
Drug Candidates ◽  
Soluble Epoxide Hydrolase Inhibitors ◽  
Orally Active

Novel soluble epoxide hydrolase inhibitors with a dihydropyrimidinone scaffold: design, synthesis and biological evaluation

MedChemComm ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 2128-2135 ◽  
Author(s):  
Elham Rezaee ◽  
Mahdi Hedayati ◽  
Laleh Hoghooghi Rad ◽  
Soraya Shahhosseini ◽  
Mehrdad Faizi ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Biological Evaluation ◽  
Scaffold Design ◽  
Urea Derivatives ◽  
Design Synthesis ◽  
Soluble Epoxide Hydrolase Inhibitors ◽  
Synthesis And Biological Evaluation

Amide non-urea derivatives with a dihydropyrimidinone ring as a novel secondary pharmacophore against the sEH enzyme were designed, synthesized and biologically evaluated.

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