scholarly journals Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus

MedChemComm ◽  
2017 ◽  
Vol 8 (5) ◽  
pp. 960-963 ◽  
Author(s):  
A. S. Sokolova ◽  
O. I. Yarovaya ◽  
M. D. Semenova ◽  
A. A. Shtro ◽  
I. R. Orshanskaya ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
In Vitro Study ◽  
Vitro Study ◽  
Design And Synthesis ◽  
Heterocyclic Derivatives ◽  
Derivatives Of

Herein, we present the design and synthesis of a series of novel heterocyclic derivatives of (−)-borneol and (−)-isoborneol as potent inhibitors of the influenza A virus.

Enhanced porphyrin accumulation using dendritic derivatives of 5-aminolaevulinic acid for photodynamic therapy: An in vitro study

2006 ◽  
Vol 38 (8) ◽  
pp. 1382-1392 ◽  
Author(s):  
Sinan Battah ◽  
Sophie O’Neill ◽  
Christine Edwards ◽  
Sherina Balaratnam ◽  
Paul Dobbin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Vitro Study ◽  
Vitro Study ◽  
Aminolaevulinic Acid ◽  
Derivatives Of

Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents

2005 ◽  
Vol 15 (17) ◽  
pp. 3953-3956 ◽  
Author(s):  
K. Suresh Babu ◽  
T. Hari Babu ◽  
P.V. Srinivas ◽  
B.S. Sastry ◽  
K. Hara Kishore ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
In Vitro Study ◽  
Vitro Study ◽  
Oroxylin A ◽  
Derivatives Of ◽  
Acyl Derivatives

Synthesis and in vitro Study of Novel 7-O-Acyl Derivatives of Oroxylin A as Antibacterial Agents.

ChemInform ◽  
2005 ◽  
Vol 36 (51) ◽  
Author(s):  
K. Suresh Babu ◽  
T. Hari Babu ◽  
P. V. Srinivas ◽  
B. S. Sastry ◽  
K. Hara Kishore ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
In Vitro Study ◽  
Vitro Study ◽  
Oroxylin A ◽  
Derivatives Of ◽  
Acyl Derivatives

scholarly journals In Vitro Study of Interactions of Carboxamide Derivatives of Amino Acid with BSA: Ultrasonic Interferometer

2018 ◽  
Vol 10 (5) ◽  
Author(s):  
Shrikant Bandupant Thakare ◽  
Pradip Vitthalrao Tekade ◽  
Ajay Madhukar Pisudde ◽  
Sachin Pande
Keyword(s):  
Amino Acid ◽  
In Vitro Study ◽  
Vitro Study ◽  
Ultrasonic Interferometer ◽  
Derivatives Of

scholarly journals Discovery of Potent Sialic Acid Inhibitors Against the Hemagglutinin of Influenza A Virus

2020 ◽  
Author(s):  
Yu-Jen Chang ◽  
Cheng-Yun Yeh ◽  
Ju-Chien Cheng ◽  
Yu-Qi Huang ◽  
Kai-Cheng Hsu ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Influenza A Virus ◽  
Influenza A ◽  
Site Model ◽  
Docking Method ◽  
Ranking Score ◽  
Model Preparation ◽  
Derivatives Of ◽  
Infectious Cycle

Abstract Influenza A virus (IAV) is hard to eradicate due to its genetic drift and reassortment ability. Neuraminidase (NA), frequently the target protein, cleaves the sialic acid (SA) and discharges virions to complete the infectious cycle. However, the increasing use of NA inhibitors aroused drug resistance in recent years. Hemagglutinin (HA), on the opposite, initiates the infectious cycle and sticks virions to cells by connecting to the host SA so that HA might be a tempting target. In this study, HA was chosen for SA-binding site model preparation to screen more than 200,000 compounds by molecular docking method in silico. According to the post-screening analysis by iGemdock and SiMMap, nine of the top twenty compounds based on the ranking score were purchased and evaluated. NSC85561 was initially identified from the compounds through the bioassays. Next, the twelve derivatives of NSC85561 were selected to consolidate the primary results. NSC85561 and two of its derivatives were finally identified as potent HA inhibitors by cell proliferation, plaque reduction, and hemagglutination inhibition assays in vitro. These results suggested that virtual screening may be a powerful tool to concise the compounds from the massive database and reduce the complicated bioassays.

Design and synthesis of a novel multifunctional stabilizer for highly stable dl-tetrahydropalmatine nanosuspensions and in vitro study

2018 ◽  
Vol 8 (6) ◽  
pp. 1285-1297 ◽  
Author(s):  
Beibei Yan ◽  
Yancai Wang ◽  
Lulu Wang ◽  
Yuqi Zhou ◽  
Xueyun Shang ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Design And Synthesis
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