Site-specific antibody modification and immobilization on a microfluidic chip to promote the capture of circulating tumor cells and microemboli

2017 ◽  
Vol 53 (29) ◽  
pp. 4152-4155 ◽  
Author(s):  
Chian-Hui Lai ◽  
Syer Choon Lim ◽  
Liang-Chun Wu ◽  
Chien-Fang Wang ◽  
Wen-Sy Tsai ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Specific Antibody ◽  
Microfluidic Chip ◽  
Capture Efficiency ◽  
Site Specific ◽  
Antibody Coating

Antibody coating via Fc-domain site-specific immobilization improves capture efficiency of circulating tumor cells and microemboli in microfluidics.

Integration of aligned polymer nanofibers within a microfluidic chip for efficient capture and rapid release of circulating tumor cells

2018 ◽  
Vol 2 (5) ◽  
pp. 891-900 ◽  
Author(s):  
Yunchao Xiao ◽  
Mengyuan Wang ◽  
Lizhou Lin ◽  
Lianfang Du ◽  
Mingwu Shen ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Microfluidic Chip ◽  
Polymer Nanofibers ◽  
Highly Efficient ◽  
Rapid Release ◽  
Aligned Nanofibers

Zwitterion-functionalized aligned nanofibers integrated with a microfluidic chip can be used for highly efficient capture and rapid release of CTCs.

Integrated Microfluidic Chip for Efficient Isolation and Deformability Analysis of Circulating Tumor Cells

2018 ◽  
Vol 2 (10) ◽  
pp. 1800200 ◽  
Author(s):  
Zongbin Liu ◽  
Rui Chen ◽  
Ying Li ◽  
Jianqiao Liu ◽  
Ping Wang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Microfluidic Chip

A microfluidic chip with double-sided herringbone microstructures for enhanced capture of rare tumor cells

2017 ◽  
Vol 5 (46) ◽  
pp. 9114-9120 ◽  
Author(s):  
Minjiao Wang ◽  
Zhihua Wang ◽  
Mingkan Zhang ◽  
Wei Guo ◽  
Ning Li ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Analytical Model ◽  
Microfluidic Chip ◽  
Capture Efficiency ◽  
Rare Tumor

This paper reports an analytical model to geometrically optimize a herringbone chip by investigating the interactions between cells and antibody-immobilized device surfaces for enhancing CTC capture efficiency.

Device for whole genome sequencing single circulating tumor cells from whole blood

Lab on a Chip ◽  
2019 ◽  
Vol 19 (19) ◽  
pp. 3168-3178 ◽  
Author(s):  
Ren Li ◽  
Fei Jia ◽  
Weikai Zhang ◽  
Fanghao Shi ◽  
Zhiguo Fang ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Genome Sequencing ◽  
Microfluidic Chip ◽  
Whole Blood ◽  
Whole Genome

To sequence single circulating tumor cells (CTCs) from whole blood, a microfluidic chip was developed to perform blood filtering/CTC enrichment/CTC sorting and in situ MDA for whole genome sequencing.

scholarly journals Wedge-shaped microfluidic chip for circulating tumor cells isolation and its clinical significance in gastric cancer

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Chaogang Yang ◽  
Nangang Zhang ◽  
Shuyi Wang ◽  
Dongdong Shi ◽  
Chunxiao Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Clinical Significance ◽  
Microfluidic Chip

Design of a Microfluidic Chip for Enrichment of Circulating Tumor Cells

2015 ◽  
Vol 645-646 ◽  
pp. 1320-1325
Author(s):  
Xi Xin Ling ◽  
Da Hai Ren ◽  
Zheng You
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Microfluidic Chip ◽  
Comsol Multiphysics ◽  
Enrichment Method ◽  
Cancer Metastases ◽  
Simulation Results ◽  
Novel Design ◽  
Identification And Characterization

Identification and characterization of CTCs can be used as a tool for the study of cancer metastases. A novel design of microfluidic chip used for enrichment of circulating tumor cells is presented in this paper. An integration of DLD method and negative enrichment method were designed to improve the throughput and recovery rate while getting intact CTCs. The DLD stage is used to separate CTCs from blood cells preliminarily, and the negative enrichment stage is used to acquire purified CTCs. Both of them were simulated with COMSOL Multiphysics. Simulation results showed that triangular micro-posts have better performance in DLD stage, and wave structures could generate better disturbance effect than herringbone structures. This chip provides a potential approach with high throughput and purity for the enrichment of CTCs.

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