scholarly journals DNA-supported palladium nanoparticles as a reusable catalyst for the copper- and ligand-free Sonogashira reaction

2017 ◽  
Vol 7 (11) ◽  
pp. 2262-2273 ◽  
Author(s):  
Ana Silvia Camacho ◽  
Iris Martín-García ◽  
Claudia Contreras-Celedón ◽  
Luis Chacón-García ◽  
Francisco Alonso
Keyword(s):  
Heterogeneous Catalyst ◽  
Palladium Nanoparticles ◽  
Coupling Reaction ◽  
Sonogashira Reaction ◽  
Reusable Catalyst ◽  
Sonogashira Coupling ◽  
Mild Conditions ◽  
Sonogashira Coupling Reaction ◽  
Ligand Free ◽  
Supported Palladium

Palladium nanoparticles on DNA have been shown to be an effective and reusable heterogeneous catalyst for the copper- and ligand-free Sonogashira coupling reaction of aryl iodides under mild conditions in air.

Environmentally Benign Microwave-Assisted Sonogashira Preparation of Aromatic Compounds

2011 ◽  
Vol 695 ◽  
pp. 113-116 ◽  
Author(s):  
Suttikiat Puechmongkol ◽  
Boonchoat Paosawatyanyong ◽  
Worawan Bhanthumnavin
Keyword(s):  
Coupling Reaction ◽  
Environmentally Benign ◽  
Conventional Heating ◽  
Microwave Activation ◽  
Sonogashira Coupling ◽  
Terminal Alkynes ◽  
Mild Conditions ◽  
Aryl Bromides ◽  
Sonogashira Coupling Reaction ◽  
Type Coupling

An efficient Sonogashira-type coupling reaction of terminal alkynes and aryl bromides by microwave activation with short reaction time under mild conditions are presented. It is illustrated herein that the traditional Sonogashira coupling reaction can be achieved with a much more efficient yet environmentally friendly condition. In contrary to the usually required 10 mol% Pd loading and the use of conventional heating at 60 °C for 24 h in order for a reaction to proceed satisfactorily, with a 100 W microwave activation, the reaction of terminal alkynes with substituted aryl bromides can be achieved with only a 2.5 mol% Pd in 10 min. The yield was improved with microwave irradiation.

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