Application of primary halogenated hydrocarbons for the synthesis of 3-aryl and 3-alkyl indolizines

2017 ◽  
Vol 15 (23) ◽  
pp. 5016-5024 ◽  
Author(s):  
Yan Liu ◽  
Huayou Hu ◽  
Junyu Zhou ◽  
Wenhui Wang ◽  
Youliang He ◽  
...  
Keyword(s):  
Transition Metal ◽  
Halogenated Hydrocarbons ◽  
Tandem Reaction ◽  
Synthetic Route ◽  
Metal Free ◽  
First Time

A transition-metal-free synthetic route to 3-aryl and 3-alkyl indolizines from electron-deficient alkenes, pyridines and primary halogenated hydrocarbons is reported for the first time using a tandem reaction.

Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

2021 ◽  
Author(s):  
Penghui Dong ◽  
Kashif Majeed ◽  
lingna Wang ◽  
Zijian Guo ◽  
Fengtao Zhou ◽  
...  
Keyword(s):  
Transition Metal ◽  
Aldol Condensation ◽  
Domino Reaction ◽  
Tandem Reaction ◽  
Metal Free ◽  
Successive Formation ◽  
General Synthesis

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds...

Transition-Metal-Free, Intermolecular Azidoheteroarylation of Alkenes: Efficient Access to β-Azidoalkylated Quinoxalinones and Preliminary Antifungal Evaluation Against Magnaporthe grisea

Synthesis ◽  
2020 ◽  
Vol 52 (16) ◽  
pp. 2395-2409
Author(s):  
Weiwei Qin ◽  
Zhaodong Li ◽  
Yiming Du ◽  
Yue Chen ◽  
Yun-Lin Liu
Keyword(s):  
Transition Metal ◽  
Magnaporthe Grisea ◽  
Single Step ◽  
Domino Reaction ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Efficient Access ◽  
First Time ◽  
Antibacterial Evaluation ◽  
Addition Pathway

An efficient, PhI(OAc)2-mediated, radical azidoheteroarylation of alkenes under transition-metal-free conditions is reported by employing TMSN3 and quinoxalin-2(1H)-ones as coupling partners. This domino reaction allows an efficient synthesis of valuable orangoazides containing quinoxalin-2(1H)-one derivatives and could be extended to phosphinyl-alkylated quinoxalin-2(1H)-one in a single step in moderate to excellent yields under mild conditions, as demonstrated by the preliminary antibacterial evaluation against Magnaporthe grisea for the first time. Mechanistic studies revealed that this transformation undergoes a cascade addition pathway controlled by a polar radical.

Construction of 6H-benzo[c]thiochromenes via a tandem reaction of arynes with thionoesters

2021 ◽  
Author(s):  
Yi An ◽  
Fang Zhang ◽  
Guangfen Du ◽  
Zhihua Cai ◽  
Lin He
Keyword(s):  
Transition Metal ◽  
Tandem Reaction ◽  
Tandem Reactions ◽  
Metal Free

A mild and transition-metal free method has been proposed for the synthesis of 6H-benzo[c]thiochromenes via the tandem reactions of arynes with thionoesters.

The peroxodisulfate-assisted three-component benzylation of coumarins with styrenes and KSCN: A transition-metal-free approach for the synthesis of 3-(1-aryl-2-thiocyanatoethyl)-2H-chromen-2-one in ethyl lactate

2021 ◽  
Author(s):  
Palani Natarajan ◽  
Priya ◽  
Deachen Chuskit
Keyword(s):  
Transition Metal ◽  
Ethyl Lactate ◽  
Metal Free ◽  
Reaction Proceeds ◽  
First Time

The peroxodisulfate-assisted three-component benzylation of coumarins with styrenes and KSCN to 3-(1-aryl-2-thiocyanatoethyl)-2H-chromen-2-one is reported for the first time. This reaction proceeds via the consecutive addition of SCN radical to styrenes...

ChemInform Abstract: An Efficient, Transition-Metal-Free Process for the Synthesis of Substituted Dihydrofurans via a Michael/Cyclization Tandem Reaction.

ChemInform ◽  
2011 ◽  
Vol 42 (20) ◽  
pp. no-no
Author(s):  
Ming-Yu Wu ◽  
Ming-Qi Wang ◽  
Kun Li ◽  
Xing-Wen Feng ◽  
Ting He ◽  
...  
Keyword(s):  
Transition Metal ◽  
Tandem Reaction ◽  
Metal Free ◽  
Free Process

Metal-free enantioselective addition of nucleophilic silicon to aromatic aldehydes catalyzed by a [2.2]paracyclophane-based N-heterocyclic carbene catalyst

2017 ◽  
Vol 15 (15) ◽  
pp. 3202-3206 ◽  
Author(s):  
Ping An ◽  
Yuwen Huo ◽  
Zhen Chen ◽  
Chun Song ◽  
Yudao Ma
Keyword(s):  
Transition Metal ◽  
Aromatic Aldehydes ◽  
Metal Free ◽  
Enantioselective Addition ◽  
First Time

A transition metal-free enantioselective 1,2-silylation of aromatic aldehydes to yield chiral α-hydroxysilanes was developed for the first time.

N- and O-doped mesoporous carbons derived from rice grains: efficient metal-free electrocatalysts for hydrazine oxidation

2016 ◽  
Vol 52 (93) ◽  
pp. 13588-13591 ◽  
Author(s):  
Katherine Koh ◽  
Yuying Meng ◽  
Xiaoxi Huang ◽  
Xiaoxin Zou ◽  
Manish Chhowalla ◽  
...  
Keyword(s):  
Hydrothermal Synthesis ◽  
Mesoporous Carbon ◽  
Oxidation Reaction ◽  
Mesoporous Carbons ◽  
Synthetic Route ◽  
Metal Free ◽  
Rice Grains ◽  
Highly Efficient ◽  
Hydrazine Oxidation ◽  
First Time

A novel synthetic route, combining hydrothermal synthesis, templating and pyrolysis, is demonstrated for the first time on biomass to produce highly efficient, metal-free mesoporous carbon electrocatalysts for the hydrazine oxidation reaction.

An efficient, transition-metal-free process for the synthesis of substituted dihydrofurans via a Michael/cyclization tandem reaction

2011 ◽  
Vol 52 (6) ◽  
pp. 679-683 ◽  
Author(s):  
Ming-Yu Wu ◽  
Ming-Qi Wang ◽  
Kun Li ◽  
Xing-Wen Feng ◽  
Ting He ◽  
...  
Keyword(s):  
Transition Metal ◽  
Tandem Reaction ◽  
Metal Free ◽  
Free Process

Construction of fluorescence-tunable pyrido-fused benzimidazoles via direct intramolecular C–H amination under transition-metal-free conditions

RSC Advances ◽  
2014 ◽  
Vol 4 (93) ◽  
pp. 51268-51271 ◽  
Author(s):  
Weitao Gong ◽  
Peng Gao ◽  
Gang Li ◽  
Hassan Mehdi ◽  
Guiling Ning ◽  
...  
Keyword(s):  
Transition Metal ◽  
Synthetic Route ◽  
Metal Free

A mild and efficient synthetic route to fluorescence-tunable pyrido-fused benzimidazole (PBI) scaffolds has been reported.

Transition-metal-free α-arylation of nitroketones with diaryliodonium salts for the synthesis of tertiary α-aryl, α-nitro ketones

2019 ◽  
Vol 55 (1) ◽  
pp. 119-122 ◽  
Author(s):  
Yang An ◽  
Xiao-Ming Zhang ◽  
Ze-Yu Li ◽  
Wen-Hui Xiong ◽  
Run-Dong Yu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
Diaryliodonium Salts ◽  
First Time

Transition-metal-free α-arylation of α-nitroketones with diaryliodonium salts has been developed for the first time and applied in the synthesis of tiletamine.

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