Synthesis of chiral sultams with two adjacent stereocenters via palladium-catalyzed dynamic kinetic resolution

2018 ◽  
Vol 5 (7) ◽  
pp. 1113-1117 ◽  
Author(s):  
Bo Song ◽  
Mu-Wang Chen ◽  
Yong-Gui Zhou
Keyword(s):  
Reductive Amination ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution ◽  
Stereogenic Centers ◽  
Palladium Catalyzed

A palladium-catalyzed intramolecular asymmetric reductive amination of racemic α-branched ketones bearing the poorly nucleophilic sulfonamides has been successfully developed through dynamic kinetic resolution, providing chiral δ-sultams with two contiguous stereogenic centers.

Asymmetric Synthesis of a Key Intermediate for Tofacitinib via a Dynamic Kinetic Resolution-Reductive Amination Protocol

2018 ◽  
Vol 22 (12) ◽  
pp. 1817-1822 ◽  
Author(s):  
Gerard K. M. Verzijl ◽  
Christian Schuster ◽  
Thomas Dax ◽  
André H. M. de Vries ◽  
Laurent Lefort
Keyword(s):  
Asymmetric Synthesis ◽  
Reductive Amination ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

Mechanism and origins of stereo- and enantioselectivities of palladium-catalyzed hydroamination of racemic internal allenes via dynamic kinetic resolution: a computational study

2020 ◽  
Vol 7 (12) ◽  
pp. 1502-1511 ◽  
Author(s):  
Zhenzhen Wu ◽  
Mei Zhang ◽  
Yu Shi ◽  
Genping Huang
Keyword(s):  
Dft Calculations ◽  
Kinetic Resolution ◽  
Computational Study ◽  
Dynamic Kinetic Resolution ◽  
Palladium Catalyzed

DFT calculations were performed to investigate the Pd-catalyzed hydroamination of racemic internal allenes with pyrazoles.

Palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones for the synthesis of trans cycloalkanols through dynamic kinetic resolution under acidic conditions

2020 ◽  
Vol 56 (43) ◽  
pp. 5815-5818 ◽  
Author(s):  
Xiang Li ◽  
Zi-Biao Zhao ◽  
Mu-Wang Chen ◽  
Bo Wu ◽  
Han Wang ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Asymmetric Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Cyclic Ketones ◽  
Palladium Catalyzed ◽  
Acidic Conditions

The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinetic resolution under acidic conditions, providing a facile access to chiral trans cycloalkanols.

Catalytic Asymmetric Reductive Amination of Aldehydes via Dynamic Kinetic Resolution

2006 ◽  
Vol 128 (40) ◽  
pp. 13074-13075 ◽  
Author(s):  
Sebastian Hoffmann ◽  
Marcello Nicoletti ◽  
Benjamin List
Keyword(s):  
Reductive Amination ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution ◽  
Catalytic Asymmetric

Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines

2014 ◽  
Vol 50 (83) ◽  
pp. 12526-12529 ◽  
Author(s):  
Mu-Wang Chen ◽  
Xian-Feng Cai ◽  
Zhang-Pei Chen ◽  
Lei Shi ◽  
Yong-Gui Zhou
Keyword(s):  
Phosphoric Acid ◽  
Kinetic Resolution ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Resolution Process ◽  
Chiral Phosphoric Acid ◽  
Stereogenic Centers ◽  
Facile Route

An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.

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