Biomonitoring of occupational exposure to 5-FU by assaying α-fluoro-β-alanine in urine with a highly sensitive UHPLC-MS/MS method

The Analyst ◽  
2018 ◽  
Vol 143 (17) ◽  
pp. 4110-4117 ◽  
Author(s):  
Alice Dhersin ◽  
Benoît Atgé ◽  
Béatrice Martinez ◽  
Karine Titier ◽  
Marine Rousset ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Healthcare Professionals ◽  
Antineoplastic Drugs ◽  
Highly Sensitive

5-Fluorouracil (5-FU) is one of the most widely antineoplastic drugs handled by healthcare professionals.

scholarly journals A highly sensitive UHPLC-MS/MS method for urine biological monitoring of occupational exposure to anthracycline antineoplastic drugs and routine application

2020 ◽  
Vol 1156 ◽  
pp. 122305
Author(s):  
Antoine Villa ◽  
Kevin Tremolet ◽  
Béatrice Martinez ◽  
Oscar Da Silva Cacao ◽  
Benoît Atgé ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Biological Monitoring ◽  
Antineoplastic Drugs ◽  
Routine Application ◽  
Highly Sensitive

Antineoplastic drugs determination by HPLC-HRMSn to monitor occupational exposure

2015 ◽  
Vol 8 (7) ◽  
pp. 730-737 ◽  
Author(s):  
Federica Dal Bello ◽  
Valentina Santoro ◽  
Valentina Scarpino ◽  
Chiara Martano ◽  
Riccardo Aigotti ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Antineoplastic Drugs

scholarly journals Occupational exposure to conventional antineoplastic drugs: can it be further limited?

2019 ◽  
Vol 27 (5) ◽  
pp. 251-252
Author(s):  
Nicolas Simon ◽  
Pascal Odou ◽  
Bertrand Décaudin ◽  
Pascal Bonnabry ◽  
Sandrine Fleury Souverain
Keyword(s):  
Occupational Exposure ◽  
Antineoplastic Drugs

Assessment of genotoxic damage in nurses occupationally exposed to antineoplastics by the analysis of chromosomal aberrations

2002 ◽  
Vol 21 (3) ◽  
pp. 129-135 ◽  
Author(s):  
S Burgaz ◽  
B Karahalil ◽  
Z Canli ◽  
F Terzioglu ◽  
G Ançel ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Population Level ◽  
Fold Increase ◽  
Mean Value ◽  
Antineoplastic Drugs ◽  
Genetic Damage ◽  
Occupationally Exposed ◽  
The Mean ◽  
Excretion Rates ◽  
Drug Handling

To estimate the genotoxic risk of occupational exposure to antineoplastic drugs, chromosomal aberration (CAs) frequencies in peripheral lymphocytes were determined for 20 nurses handling antineoplastics and 18 referents matched for age and sex. Urinary cyclophosphamide (CP) excretion rates, which are used as a marker for drug handling, were also measured on these nurses. We have observed significant frequencies of CAs (about 2.5-fold increase) including chromatid breaks, gaps, and acentric fragments for nurses handling antineoplastics as compared to control subjects (p<0.05, p<0.01, excluding and including gaps, respectively). The mean value of CP excretion rate for 12 nurses was 1.63 μg/24 h, suggesting that when the nurses handled CP (and other antineoplastic drugs) this particular compound was absorbed. Our study has shown that increased genetic damage was evident in nurses, at population level, due to occupational exposure to antineoplastics. Until the effects of handling antineoplastics from low-level exposure are known, it will be important to keep the exposure to a minimum.

Validated method for occupational cyclophosphamide monitoring using LC-MS/MS and a Poroshell 120 column

2015 ◽  
Vol 69 (11) ◽  
Author(s):  
Beril Anılanmert ◽  
Sefika Sertler ◽  
Fatma Cavus ◽  
Salih Cengiz
Keyword(s):  
Health Care ◽  
Occupational Exposure ◽  
Health Care Workers ◽  
Liquid Extraction ◽  
Antineoplastic Drugs ◽  
High Recovery ◽  
Pharmacy Staff ◽  
Liquid Liquid Extraction ◽  
Care Workers ◽  
Sensitive Method

AbstractPharmacy staff and health care workers in hospitals may be exposed to antineoplastic drugs during cancer chemotherapy. Sensitive methods should be used to monitor the occupational exposure in biofluids such as urine. In this study, a sensitive method for cyclophosphamide determination in urine with high recovery was developed and validated for monitoring occupational exposure. Triple liquid-liquid extraction with ethyl acetate/dichloromethane (φ

Biomarker end-points in occupational exposure to antineoplastic drugs

2010 ◽  
Vol 196 ◽  
pp. S79
Author(s):  
A. Colacci ◽  
S. Perdichizzi ◽  
P. Silingardi ◽  
M.C. Nucci ◽  
M. Vaccari ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Antineoplastic Drugs ◽  
End Points
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