Antineoplastic drugs determination by HPLC-HRMSn to monitor occupational exposure

2015 ◽  
Vol 8 (7) ◽  
pp. 730-737 ◽  
Author(s):  
Federica Dal Bello ◽  
Valentina Santoro ◽  
Valentina Scarpino ◽  
Chiara Martano ◽  
Riccardo Aigotti ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Antineoplastic Drugs

scholarly journals Occupational exposure to conventional antineoplastic drugs: can it be further limited?

2019 ◽  
Vol 27 (5) ◽  
pp. 251-252
Author(s):  
Nicolas Simon ◽  
Pascal Odou ◽  
Bertrand Décaudin ◽  
Pascal Bonnabry ◽  
Sandrine Fleury Souverain
Keyword(s):  
Occupational Exposure ◽  
Antineoplastic Drugs

Assessment of genotoxic damage in nurses occupationally exposed to antineoplastics by the analysis of chromosomal aberrations

2002 ◽  
Vol 21 (3) ◽  
pp. 129-135 ◽  
Author(s):  
S Burgaz ◽  
B Karahalil ◽  
Z Canli ◽  
F Terzioglu ◽  
G Ançel ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Population Level ◽  
Fold Increase ◽  
Mean Value ◽  
Antineoplastic Drugs ◽  
Genetic Damage ◽  
Occupationally Exposed ◽  
The Mean ◽  
Excretion Rates ◽  
Drug Handling

To estimate the genotoxic risk of occupational exposure to antineoplastic drugs, chromosomal aberration (CAs) frequencies in peripheral lymphocytes were determined for 20 nurses handling antineoplastics and 18 referents matched for age and sex. Urinary cyclophosphamide (CP) excretion rates, which are used as a marker for drug handling, were also measured on these nurses. We have observed significant frequencies of CAs (about 2.5-fold increase) including chromatid breaks, gaps, and acentric fragments for nurses handling antineoplastics as compared to control subjects (p<0.05, p<0.01, excluding and including gaps, respectively). The mean value of CP excretion rate for 12 nurses was 1.63 μg/24 h, suggesting that when the nurses handled CP (and other antineoplastic drugs) this particular compound was absorbed. Our study has shown that increased genetic damage was evident in nurses, at population level, due to occupational exposure to antineoplastics. Until the effects of handling antineoplastics from low-level exposure are known, it will be important to keep the exposure to a minimum.

Validated method for occupational cyclophosphamide monitoring using LC-MS/MS and a Poroshell 120 column

2015 ◽  
Vol 69 (11) ◽  
Author(s):  
Beril Anılanmert ◽  
Sefika Sertler ◽  
Fatma Cavus ◽  
Salih Cengiz
Keyword(s):  
Health Care ◽  
Occupational Exposure ◽  
Health Care Workers ◽  
Liquid Extraction ◽  
Antineoplastic Drugs ◽  
High Recovery ◽  
Pharmacy Staff ◽  
Liquid Liquid Extraction ◽  
Care Workers ◽  
Sensitive Method

AbstractPharmacy staff and health care workers in hospitals may be exposed to antineoplastic drugs during cancer chemotherapy. Sensitive methods should be used to monitor the occupational exposure in biofluids such as urine. In this study, a sensitive method for cyclophosphamide determination in urine with high recovery was developed and validated for monitoring occupational exposure. Triple liquid-liquid extraction with ethyl acetate/dichloromethane (φ

Biomarker end-points in occupational exposure to antineoplastic drugs

2010 ◽  
Vol 196 ◽  
pp. S79
Author(s):  
A. Colacci ◽  
S. Perdichizzi ◽  
P. Silingardi ◽  
M.C. Nucci ◽  
M. Vaccari ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Antineoplastic Drugs ◽  
End Points

scholarly journals Analytical strategies for assessing occupational exposure to antineoplastic drugs in healthcare workplaces

2018 ◽  
Author(s):  
Stefano Dugheri ◽  
Alessandro Bonari ◽  
Ilenia Pompilio ◽  
Pierpaolo Boccalon ◽  
Daniela Tognoni ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Antineoplastic Drugs ◽  
Analytical Strategies

scholarly journals Evaluation of the Safety Precaution to Occupational Exposure to Antineoplastic Drugs in the Department of Pharmacy

2013 ◽  
Vol 39 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Hiroyuki Nakano ◽  
Jin Yoshida ◽  
Keiko Komori ◽  
Chie Mochizuki ◽  
Yoko Nakata ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Antineoplastic Drugs ◽  
Safety Precaution

scholarly journals Extent of Primary DNA Damage Measured by the Comet Assay in Health Professionals Exposed to Antineoplastic Drugs: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 17 (2) ◽  
pp. 523 ◽  
Author(s):  
Vincenza Gianfredi ◽  
Daniele Nucci ◽  
Cristina Fatigoni ◽  
Tania Salvatori ◽  
Milena Villarini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Damage ◽  
Occupational Exposure ◽  
Health Professionals ◽  
Meta Analysis ◽  
Positive Association ◽  
Antineoplastic Drugs ◽  
Trim And Fill ◽  
Meta Analyses ◽  
Primary Dna Damage

Background: Antineoplastic drugs (ANDs) are a broad group of chemicals showing, at the same time, carcinogenic effects. The potential, albeit true, risk of side effects cannot be accepted, especially if resulting from occupational exposure. The aim of this study was to evaluate the association between occupational exposure to ANDs and the extent of primary DNA damage in health professionals. Methods: A systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed/Medline, Web of Science, and Scopus were used to perform the literature search. The databases were examined in July 2019. Sub-group, moderator, and cumulative analyses were conducted. The trim and fill method was used in the case of potential publication bias. Results: Twenty studies were included in the qualitative analysis, and 19 in quantitative evaluation. The pooled effect size was 1.27 [(95% confidence interval (CI) = 0.66–1.88), p = 0.000] based on 1569 subjects. The moderator analysis by duration of exposure showed a positive association between duration of exposure and primary DNA damage. Conclusions: This systematic review clearly shows a significant association between occupational exposure to ANDs and the extent of primary DNA damage in health professionals. Considering these results, health professionals should be warned against this potential occupational risk.

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