BIOMONITORING OF SEVOFLURANE EXPOSURE IN ANESTHESIOLOGIST

ABSTRACTSevoflurane is used by anesthetists for the induction and maintenance of general anesthesia. This causes the anesthetist to get daily exposures. This will be a potential hazard for exposed operating room personnel, especially anesthetists. The adverse health effects of sevoflurane as hepatotoxic, nephrotoxic and neurotoxic in the human body can be a risk for anaesthetists. Biological monitoring can be done by measuring the levels of sevoflurane and its metabolites or by looking at biomarkers for their effects on health effects. The aim of this study was to seek a literature review on the biomonitoring of sevoflurane exposure in anaesthetists. We searched the literature review using the PRISMA method in PubMed and Google scholar using the following keywords "occupational disease" "chronic effects" "anaesthetist" "sevoflurane exposure" "inorganic fluoride" "biomarkers" previously using the term MeSH and combined with Boolen "OR" and AND". We obtain 75 articles taken from the database, excluded 35 articles, and selected 5 articles. The results of the review articles showed that there were health effects, especially on liver and kidney function in chronic exposure. Biological monitoring can be undertaken by detecting sevoflurane and its metabolites in the urine during work and function of the liver and kidneys. The evidence for biological monitoring as surveillance in anaesthesiologists remain inconsistent due to limited studies. We recommend to measure sevoflurane in ambient air using a hierarchy of controls, such as elimination, replacement, engineering, administrative and personal protective equipment. We need to undertaken environmental and biological monitoring in order to acquire a safe and healthy work environment. Keywords: sevoflurane exposure, occupational health, anesthesiologist

BONE ALUMINUM AS A BIOLOGICAL MONITORING OF OCCUPATIONAL EXPOSURE TO ALUMINUM

ABSTRACTThe current proposed biological monitoring of aluminum is based on the analysis of aluminum concentration in blood/serum or in urine, but both considered to be reflective of short-term exposure. Based on its toxic kinetics, aluminum has been demonstrated to be accumulated in the bone. The aim of this study is to find out whether by analyzing bone aluminum, we might have an overview of aluminum accumulation that might cause health problems in the future. This review was conducted through a method of search and selection of articles from Pubmed, Cochrane Library, and Google Scholar databases aimed to answer question rising from the problem statement of this study. The process of searching articles used the keywords “occupational aluminum” OR “bone aluminum” AND “biological monitoring” OR “biomonitoring”. The selection of articles was performed using the defined inclusion and exclusion criteria. Initially, 61 articles were obtained, but after the selection process and hand searching, four articles remained consisting of two case reports and two cross sectional studies. Based on the selected evidence-based resources, bone can be a promising potential biomarker of aluminum, especially for cumulative exposure assessment. The use of in vivo neutron activation analysis (IVNAA) or X-ray fluorescence (XRF) technology for the purpose of noninvasively quantifying aluminum concentration in the bone, is suitable enough to be performed in occupational settings. Keywords: Bone aluminum, occupational exposure, IVNAA, XRF, biomonitoring, biological monitoring

Impact of marine protected areas on economical important coral reef fish communities: An evaluation of the biological monitoring of coral reef fish in Anambas Islands, Indonesia

Putra RD, Siringiringo RM, Suryanti A, Sari NWP, Sinaga M, Hidayati NV, Hukom FD, Abrar M, Makatipu PC, Sianturi R, Ilham Y. 2021. Impact of marine protected areas on economical important coral reef fish communities: An evaluation of the biological monitoring of coral reef fish in Anambas Islands, Indonesia. Biodiversitas 22: 4169-4181. The use of Marine Protected Areas (MPAs) is the core strategy to reduce the impact of the anthropogenic stressor on marine fisheries, especially in reducing the overexploitation of fisheries resources and destructive fishing in which this plays a significant role in the conservation of marine biodiversity and populations. We conducted a study over 4 years to evaluate and assess the impact of MPAs on economically important reef fish in the Anambas Islands. We compared density, size, biomass, and diversity indices from the seven families of coral reef fish (Acanthuridae, Haemulidae, Lethrinidae, Lutjanidae, Scaridae, Siganidae, and Serranidae) using Underwater Visual Census (UVC) with a total of 12 MPAs stations (70-m transect). Multivariate analysis of variance (MANOVA) was used to evaluate and assess reserve protection on the coral reef fish, and several ecological indices were used to compare the potential change of economically coral reef fish diversity. We also measured the rate of change in coral cover to identify the effectiveness of the MPAs. After 4 years of studies, our result showed that there was an increase of economical reefs. Fish diversity, density, and biomass increased by 244%, 257%, and 179% respectively. There was no significant difference in the rate of coral cover change among MPAs stations. Economical coral reef fish in Anambas Islands were restored in marine reserve overtimes after fisheries restriction protection, but this does not change the rate of coral cover through time. In addition, the government managed and increased community awareness that significantly influenced decreasing destructive fishing practices and overexploited reef fish species in Anambas Islands but no change in coral cover. The MPAs environmental condition and natural disturbance, including thermal stress and high sedimentation, play a key role in coral cover recovery besides fisheries restriction in the MPAs area.