Oxidative NHC catalysis: direct activation of β sp3 carbons of saturated acid chlorides

2019 ◽  
Vol 55 (3) ◽  
pp. 298-301 ◽  
Author(s):  
Shi-Ya Zhu ◽  
Hua Zhang ◽  
Qing-Wei Ma ◽  
Dou Liu ◽  
Xin-Ping Hui

The first activation of saturated acid chlorides by an oxidative N-heterocyclic carbene catalyst has been utilized to synthesize enantio-enriched spirooxindole lactones and δ-lactones.


1965 ◽  
Vol 49 (2) ◽  
pp. 299-304 ◽  
Author(s):  
P. F. Kraicer ◽  
M. C. Shelesnyak

ABSTRACT One mg of ergocornine methanesulphate was injected into pseudopregnant rats; the time at which the vaginal smear became pro-oestrous was noted. Pro-oestrus appeared two days after the injection of ergocornine, independent of whether the drug was administered on days L1, L2, L3, L4 or L5 (L1 = first day of leucocytic vaginal smear). Injection of 5 mg/d progesterone delayed, but did not usually prevent, the onset of pro-oestrus. Pro-oestrus appeared 3 days after the last injection of progesterone. These results show that ergocornine induces the appearance of oestrus by effecting progesterone withdrawal rather than by direct activation of folliculotrophins.



2019 ◽  
Author(s):  
Kathrin Landgraf ◽  
Nora Klöting ◽  
Martin Gericke ◽  
Nitzan Maixner ◽  
Esther Guiu-Jurado ◽  
...  


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