STUDIES ON THE MECHANISM OF NIDATION. XVI.
ABSTRACT One mg of ergocornine methanesulphate was injected into pseudopregnant rats; the time at which the vaginal smear became pro-oestrous was noted. Pro-oestrus appeared two days after the injection of ergocornine, independent of whether the drug was administered on days L1, L2, L3, L4 or L5 (L1 = first day of leucocytic vaginal smear). Injection of 5 mg/d progesterone delayed, but did not usually prevent, the onset of pro-oestrus. Pro-oestrus appeared 3 days after the last injection of progesterone. These results show that ergocornine induces the appearance of oestrus by effecting progesterone withdrawal rather than by direct activation of folliculotrophins.
1973 ◽
Vol 31
◽
pp. 552-553
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