Mechanistic insights into peptide and ligand binding of the ATAD2-bromodomain via atomistic simulations disclosing a role of induced fit and conformational selection

2018 ◽  
Vol 20 (36) ◽  
pp. 23222-23232 ◽  
Author(s):  
Yang Zhou ◽  
Muzammal Hussain ◽  
Guanglin Kuang ◽  
Jiancun Zhang ◽  
Yaoquan Tu
Keyword(s):  
Ligand Binding ◽  
Peptide Binding ◽  
Atomistic Simulations ◽  
Induced Fit ◽  
Conformational Selection

Atomistic simulations of the ATAD2-bromodomain disclose a role of induced fit and conformational selection upon ligand and peptide binding.

scholarly journals A Role for Both Conformational Selection and Induced Fit in Ligand Binding by the LAO Protein

2011 ◽  
Vol 7 (5) ◽  
pp. e1002054 ◽  
Author(s):  
Daniel-Adriano Silva ◽  
Gregory R. Bowman ◽  
Alejandro Sosa-Peinado ◽  
Xuhui Huang
Keyword(s):  
Ligand Binding ◽  
Induced Fit ◽  
Conformational Selection

scholarly journals Essential role of conformational selection in ligand binding

2014 ◽  
Vol 186 ◽  
pp. 13-21 ◽  
Author(s):  
Austin D. Vogt ◽  
Nicola Pozzi ◽  
Zhiwei Chen ◽  
Enrico Di Cera
Keyword(s):  
Ligand Binding ◽  
Essential Role ◽  
Conformational Selection

scholarly journals Induced Fit or Conformational Selection? The Role of the Semi-closed State in the Maltose Binding Protein

Biochemistry ◽  
2011 ◽  
Vol 50 (48) ◽  
pp. 10530-10539 ◽  
Author(s):  
Denis Bucher ◽  
Barry J. Grant ◽  
J. Andrew McCammon
Keyword(s):  
Binding Protein ◽  
Maltose Binding Protein ◽  
Induced Fit ◽  
Conformational Selection ◽  
Closed State
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