scholarly journals The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates

2019 ◽  
Vol 10 (20) ◽  
pp. 5197-5210 ◽  
Author(s):  
Philipp Klahn ◽  
Verena Fetz ◽  
Antje Ritter ◽  
Wera Collisi ◽  
Bettina Hinkelmann ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Nuclear Export ◽  
Drug Conjugates ◽  
Targeted Drug ◽  
Potent Effector

Ratjadone derivatives have been successfully introduced as suitable payloads with new mode of action for targeted drug conjugates.

Generation and Biological Evaluation of Fc Antigen Binding Fragment-Drug Conjugates as a Novel Antibody-Based Format for Targeted Drug Delivery

2021 ◽  
Author(s):  
Sebastian Jäger ◽  
Tim R. Wagner ◽  
Nicolas Rasche ◽  
Harald Kolmar ◽  
Stefan Hecht ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Biological Evaluation ◽  
Antigen Binding ◽  
Drug Conjugates ◽  
Targeted Drug

scholarly journals 2019 FDA TIDES (Peptides and Oligonucleotides) Harvest

2020 ◽  
Vol 13 (3) ◽  
pp. 40 ◽  
Author(s):  
Danah Al Shaer ◽  
Othman Al Musaimi ◽  
Fernando Albericio ◽  
Beatriz G. de la Torre
Keyword(s):  
Adverse Effects ◽  
Mode Of Action ◽  
Chemical Structure ◽  
Imaging Agents ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Target Mode ◽  
Medical Indications ◽  
Antibody Drug ◽  
The Way

2019 has been an excellent year in terms of peptides and oligonucleotides (TIDES) approved by the FDA. Despite the drop in the number of total drugs approved by the FDA in 2019 in comparison with 2018 (48 vs. 59), the total number of TIDES authorized increased (seven vs. three). Year after year, TIDES are increasingly present in therapy, as imaging agents, theragnostic and constituent moieties of other complex drugs, such as antibody drug conjugates. This means a consolidation of these kinds of drugs in the pharmaceutical arena, paving the way in the coming years for the approval of others for diverse medical indications. Here the TIDES approved in 2019 are analyzed in terms of chemical structure, medical target, mode of action, and adverse effects.

Antibody–drug conjugates: targeted drug delivery for cancer

2010 ◽  
Vol 14 (4) ◽  
pp. 529-537 ◽  
Author(s):  
Stephen C Alley ◽  
Nicole M Okeley ◽  
Peter D Senter
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Targeted Drug ◽  
Antibody Drug

Polymer–Drug Conjugates for Targeted Drug Delivery

2014 ◽  
pp. 389-407 ◽  
Author(s):  
Anjan Kumar Mohanty ◽  
Fahima Dilnawaz ◽  
Guru Prasad Mohanta ◽  
Sanjeeb Kumar Sahoo
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Conjugates ◽  
Targeted Drug ◽  
Polymer Drug Conjugates

Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates

2018 ◽  
Vol 28 (3) ◽  
pp. 382-387 ◽  
Author(s):  
Rostislav A. Petrov ◽  
Svetlana Yu. Maklakova ◽  
Yan A. Ivanenkov ◽  
Stanislav A. Petrov ◽  
Olga V. Sergeeva ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Drug Conjugates ◽  
Targeted Drug ◽  
Synthesis And Biological Evaluation

Innovative Linker Strategies for Tumor‐Targeted Drug Conjugates

2019 ◽  
Vol 25 (65) ◽  
pp. 14740-14757 ◽  
Author(s):  
Alberto Dal Corso ◽  
Luca Pignataro ◽  
Laura Belvisi ◽  
Cesare Gennari
Keyword(s):  
Drug Conjugates ◽  
Targeted Drug

scholarly journals Frontispiece: Innovative Linker Strategies for Tumor‐Targeted Drug Conjugates

2019 ◽  
Vol 25 (65) ◽  
Author(s):  
Alberto Dal Corso ◽  
Luca Pignataro ◽  
Laura Belvisi ◽  
Cesare Gennari
Keyword(s):  
Drug Conjugates ◽  
Targeted Drug

Synthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates

2018 ◽  
Vol 28 (3) ◽  
pp. 503-508 ◽  
Author(s):  
Yan A. Ivanenkov ◽  
Alexander G. Majouga ◽  
Rostislav A. Petrov ◽  
Stanislav A. Petrov ◽  
Sergey V. Kovalev ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Drug Conjugates ◽  
Targeted Drug ◽  
Synthesis And Biological Evaluation

Peptide-drug conjugates in targeted drug delivery to cancer

2021 ◽  
pp. 147-161
Author(s):  
Subhashis Debnath ◽  
Bhaskarjyoti Gogoi ◽  
D. Swetha
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Peptide Drug ◽  
Drug Conjugates ◽  
Targeted Drug ◽  
Peptide Drug Conjugates
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