Evaluation of the efficiency of application of president sensitive toothpaste in dental hyperesthesia after professional diode laser whitening

Taking into account the high demand for professional teeth whitening in patients, as well as a significant high percentage of hyperesthesia after this medical manipulation, the urgency of solving this problem becomes obvious. Our study was carried out in 17 patients aged 20 to 35 years with complaints of hyperesthesia after professional teeth whitening with a diode laser with a wavelength of 810 nm using President Sensitive toothpaste with potassium nitrate and strontium chloride at home. All patients underwent professional oral hygiene before teeth whitening, recommended toothpaste and a brush, and received training in home care and teeth cleaning. According to our research, the toothpaste with potassium nitrate and strontium chloride has a pronounced desensitive effect and corresponds to the declared parameters. Thus, after professional whitening with a diode laser with a wavelength of 810 nm and subsequent application of toothpaste with potassium nitrate and strontium chloride, a decrease in tooth sensitivity, remineralization of hard tissues and suppression of bacterial growth were revealed. However, the selection should be individualized, taking into account all medical indications and properties of hygiene products.

Artificial intelligence unifies knowledge and actions in drug repositioning

Drug repositioning aims to reuse existing drugs, shelved drugs, or drug candidates that failed clinical trials for other medical indications. Its attraction is sprung from the reduction in risk associated with safety testing of new medications and the time to get a known drug into the clinics. Artificial Intelligence (AI) has been recently pursued to speed up drug repositioning and discovery. The essence of AI in drug repositioning is to unify the knowledge and actions, i.e. incorporating real-world and experimental data to map out the best way forward to identify effective therapeutics against a disease. In this review, we share positive expectations for the evolution of AI and drug repositioning and summarize the role of AI in several methods of drug repositioning.

Impact of maternal nationality on caesarean section rate variation in a high-income country

Background: Caesarean section (CS) rates have been reported to differ between immigrants and native-born women in high-income countries. Objective: We assessed the CS rate and its relationship with the CS rate in country of nationality and other explanatory factors among women of different nationalities including Qatari women who underwent deliveries at our hospital to generate evidence that will quantify and help explain the observed CS rates in our hospital. Methods: In this retrospective cross-sectional study conducted at the second-largest public maternity hospital in Qatar, Al-Wakra Hospital (AWH), data for all births delivered in 2019 were retrieved from the hospital's electronic medical records. The CS rates and the crude and adjusted risks of Caesarean delivery for mothers from each nationality were determined, and the common indications for CS were analyzed based on nationality. The association between nationality and Caesarean delivery was examined using binomial logistic regression analysis, with Qatari women as the reference group. The correlation between CS rate in country of nationality and observed CS rates in Qatar was also examined using Pearson's correlation. Results: The study population consisted of 4816 births by women of 68 nationalities, of which 4513 births were by women from 25 countries. The highest proportion of deliveries (n-1247, 25.9%) was by Indian women. The frequency of CS was the highest and lowest among Egyptian (49.6%) and Yemeni women (17.9%), respectively. Elective CS was predominantly performed in women of Arab nationalities; the most common indication was a history of previous multiple CSs. Emergency CS was primarily performed in women of Asian and Sub-Saharan African nationalities; the most common indications were failure to progress and fetal distress. For most nationalities, the CS rate in Qatar was associated with those of the countries of nationality. Conclusions: The observed CS rates varied widely among women of different nationalities. The variation was influenced by maternal factors and medical indications as well as the CS rates in the country of nationality. We posit that cultural preferences, acculturation, and patient expectations influenced observed findings. More efforts are required to reduce primary CS rates and to help women make the most informed decisions regarding modes of delivery. Key Message: CS rates varied widely among women of different nationalities. The variation was influenced by medical indications, maternal preferences, and CS rate in countries of nationality. The solution to reducing CS rates should be a culturally informed response.

Trends in delivery mode occurring during the Covid-19 pandemic and risks in long-term urogynecology cases: A narrative review

HIGHLIGHT 1. Trend of delivery types during Covid-19 pandemic and the risk of urogynecology cases, particularly sexual dysfunction, pelvic floor dysfunction and stress urinary incontinence, was reviewed.2. Cesarean section was found higher than normal deliveries due to the consideration of possiblee exposure to the virus.3. Sexual dysfunction was found not to have relations to mode of delivery, but those with mode of delivery other than normal likely had dyspareunia at 18 months postpartum.4. The choice of method of delivery needs to be determined wisely by considering medical indications and the risk factors. ABSTRACTWomen's quality of life in the long term is also influenced by their reproductive health. Various diseases appear related to urogynecology cases such as sexual dysfunction, pelvic floor dysfunction and stress urinary incontinence. The study reviews the trend of types of delivery during the pandemic and the risk of urogynecology cases, especially in the three cases. The narrative review study was conducted using the PubMed, Science Direct, and Google Scholar databases. The results showed that the percentage of cesarean section was higher than normal deliveries because of the view on the safety of exposure to the virus. Several studies have found that sexual dysfunction was not related to mode of delivery but women who delivered by emergency caesarean section, vacuum extraction, or caesarean section were more likely to report dyspareunia at 18 months postpartum but adjusted for maternal age and other confounders. Meanwhile, compared with spontaneous vaginal delivery, cesarean delivery with a protective effect or reduction of stress urinary incontinence, overactive bladder, and pelvic organ prolapse. There is a tendency to choose a certain pattern of delivery so that the choice of method needs to be chosen wisely and through medical indications and consider risk factors for long-term reproductive health problems.

Between “Medical” and “Social” Egg Freezing

Egg freezing has led to heated debates in healthcare policy and bioethics. A crucial issue in this context concerns the distinction between “medical” and “social” egg freezing (MEF and SEF)—contrasting objections to bio-medicalization with claims for oversimplification. Yet such categorization remains a criterion for regulation. This paper aims to explore the “regulatory boundary-work” around the “medical”–”social” distinction in different egg freezing regulations. Based on systematic documents’ analysis we present a cross-national comparison of the way the “medical”–”social” differentiation finds expression in regulatory frameworks in Austria, Germany, Israel, and the Netherlands. Findings are organized along two emerging themes: (1) the definition of MEF and its distinctiveness—highlighting regulatory differences in the clarity of the definition and in the medical indications used for creating it (less clear in Austria and Germany, detailed in Israel and the Netherlands); and (2) hierarchy of medical over social motivations reflected in usage and funding regulations. Blurred demarcation lines between “medical” and “social” are further discussed as representing a paradoxical inclusion of SEF while offering new insights into the complexity and normativity of this distinction. Finally, we draw conclusions for policymaking and the bioethical debate, also concerning the related cryopolitical aspects.

MATERNAL FACTORS ON LABOR WITH CESAREAN SECTION HISTORY

Background : Cesarean section without medical indications can have negativity in developing or developed countries. Cesarean section is a medical intervention in certain circumstance but must be recognized as a major surgical procedure with potential risks to the mother and baby. This research aim to analyze maternal factors in labor with a history of cesarean esction. Method : this research was a cross sectional method with collected 72 medical records in RSUD Dr. M. Soewandhie Surabaya. Result : Maternal age, interpregnancy interval, indication of past Cesarean section, and BMI during pregnancy, did not correlate with method of delivery. Factors which correlated to method of delivery after Cesarean section were prior vaginal delivery (p=0,044) and length of stay (p=0,000). Conclusion : There is a relationship between the factors of vaginal birth history and length of stay with delivery method.

P.106 Intravenous lacosamide use in pre-school children

Background: Data on intravenous lacosamide use in young pediatric patients is scarce, especially of pre-school age. Methods: We retrospectively reviewed the medical records of all patients less than 6 years old who received intravenous lacosamide at our tertiary pediatric hospital. Data on dose, timing and order of administration was collected. Clinical and electrographic response was independently assessed with EEG interpretation blinded to time of administration. For adverse effects surveillance, heart rate was noted before and 1 hour after dose. Results: Eleven patients (8 boys), received lacosamide between 2013 and 2018. Mean age was 2 years (11 days – 5,3 years). Medical indications were: refractory status epilepticus (n=6), repetitive seizures (n=4), and inability to take oral lacosamide (n=1). On average, lacosamide was the fifth (1st-8th) IV antiepileptic drug administered 78 hours (SD 11 hours) after presentation. The most frequent dose was 5 mg/kg. Clinical response was confirmed in 7 patients, while electrographic response was proven in 3 patients. Seizure relapse at 24 hours was noted in 6 patients. No bradycardia occurred post-lacosamide. Conclusions: Although very safe, therapeutic response to lacosamide in young pediatric patients was inconclusive, mostly due to delay in administration, suboptimal dose, and high number of other IV antiepileptic drugs previously given.

Analysis Of Outside Claim Fragmentation On BPJS Claims In Hospital

The Social Security Organizing Agency (BPJS) has provisions regardingfraud in which one form of fraud is the breakdown of service episodes that are not in accordance with medical indications (serviceunbundling or fragmentation)it is done by health care providers in Health Facilities Referral Follow-Up (FKRTL) the action is done intentionally, to get financial benefits from public relations. Health Insurance program in the National Social Security System through fraudulent acts that are not in accordance with the provisions of the laws and regulations. The purpose of this study is to analyze the occurrence of Fragmentation in Hospital X. This research method uses quantitative methods from the data obtained. The results of this study of the Hospital conducted fragmentation in february 33 files and march 24 files and the number of fragmentation in mountax services. The hospital argued not to experience losses because the claim package that has been arranged by the Health Insurance Organizing Agency (BPJS) Instead of the Health Insurance Organizing Agency (BPJS) prohibits fragmentation because it includesfraud. In this study, the hospital can fragment because it is not applied standard operating procedures properly and in accordance with PERMENKES Number 16 of 2020 the hospital must have a fraud prevention team in order to conduct early detection.

Prevalensi Karies dan Erosi pada Narapidana Pengguna Narkotika Jenis Sabu-Sabu di Lembaga Pemasyarakatan Klas II-A Kabupaten Jember

The problem of methamphetamine abuse in Indonesia is still very concerning even though the prohibition on consuming narcotics outside of medical indications has been regulated in law. Methamphetamine users are at high risk for tooth decay, tooth decay that often occurs in methamphetamine users is caries and erosion. This is because the abuse of methamphetamine can affect the oral hygiene and saliva quality of the users. Given the high risk of methamphetamine users being exposed to caries and erosion, researchers need to conduct research that aims to determine the prevalence of caries and erosion, as well as describe the characteristics of inmates who use shabushabu narcotics in the Class II-A Penitentiary Office Jember. There are 58 respondents in this study. Caries measurement was carried out using the DMF-T index, erosion measurement was carried out using the Basic Erosive Wear Examination, while the characteristics of the respondents were obtained through a questionnaire sheet. The result is that the prevalence of caries in methamphetamine users is 89.66% with a mean DMF-T score of 7.21 and the prevalence of erosion is 72.41% with a mean erosion score of 5.29. It can be concluded that most users of methamphetamine have caries and erosion problems in their teeth.

Trends in Ketamine Use, Exposures, and Seizures in the United States

Objectives. To determine whether there have been shifts in nonmedical ketamine use, poisonings (“exposures”), and seizures. Methods. We used generalized additive models to detect trends in past-year use (2006–2019), exposures (1991–2019), and seizures (2000–2019) involving ketamine in the United States. Results. There was a quarterly increase in self-reported past-year nonmedical ketamine use in 2006 to 2014 (Β = 0.21; P = .030) and an increase in 2015 to 2019 (Β = 0.29; P = .036), reaching a peak of 0.9% in late 2019. The rate of exposures increased from 1991 through 2019 (Β = 0.87; P = .006), and there was an increase to 1.1 exposures per 1 000 000 population in 2014, with rates remaining stable through 2019. The rate of ketamine seizures increased from 2000 through 2019 (Β = 2.27; P < .001), with seizures reaching a peak in 2019 at 3.2 per 1000 seizures. Conclusions. Indicators suggest that ketamine use and availability has increased, including before increased medical indications, but nonmedical use is still currently uncommon despite increased acceptance and media coverage. (Am J Public Health. Published online ahead of print October 7, 2021:e1–e4. https://doi.org/10.2105/AJPH.2021.306486 )