Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

Three new biocompatible porphyrin-based oxygen photosensitisers were tested in vitro on breast cancer cells via 2P-PDT: one of them, 66 times more active than H2TPP, gave quite promising results for theranostic applications.

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m-THPC-Mediated Photodynamic Therapy (PDT) Does Not Induce Resistance to Chemotherapy, Radiotherapy or PDT on Human Breast Cancer Cells In Vitro

Photochemistry and Photobiology ◽

10.1111/j.1751-1097.1998.tb02515.x ◽

1998 ◽

Vol 68 (4) ◽

pp. 569-574 ◽

Cited By ~ 28

Author(s):

René Hornung ◽

Heinrich Walt ◽

Nigel E. A. Crompton ◽

Kristin Anne Keefe ◽

Brigitte Jentsch ◽

...

Keyword(s):

Breast Cancer ◽

Photodynamic Therapy ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Induce Resistance ◽

Resistance To Chemotherapy

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Distribution, Trafficking, and in Vitro Photodynamic Therapy Efficacy of Cholesterol Silicon(IV) Phthalocyanine and Its Nanoparticles in Breast Cancer Cells

ACS Applied Bio Materials ◽

10.1021/acsabm.9b00909 ◽

2019 ◽

Vol 2 (12) ◽

pp. 5976-5984 ◽

Cited By ~ 1

Author(s):

Xiuqin Chen ◽

Qiumei Guo ◽

Shiqing Dong ◽

Jianling Chen ◽

Shusen Xie ◽

...

Keyword(s):

Breast Cancer ◽

Photodynamic Therapy ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Therapy Efficacy

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In vitro combined effect of Doxorubicin and sulfonated zinc Phthalocyanine–mediated photodynamic therapy on MCF-7 breast cancer cells

Tumor Biology ◽

10.1177/1010428317727278 ◽

2017 ◽

Vol 39 (10) ◽

pp. 101042831772727 ◽

Cited By ~ 6

Author(s):

Eric Chekwube Aniogo ◽

Blassan Plackal Adimuriyil George ◽

Heidi Abrahamse

Keyword(s):

Breast Cancer ◽

Photodynamic Therapy ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Combined Effect ◽

Zinc Phthalocyanine ◽

Mcf 7

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Fluorescent periodic mesoporous organosilica nanoparticles dual-functionalized via click chemistry for two-photon photodynamic therapy in cells

Journal of Materials Chemistry B ◽

10.1039/c6tb00638h ◽

2016 ◽

Vol 4 (33) ◽

pp. 5567-5574 ◽

Cited By ~ 29

Author(s):

Jonas G. Croissant ◽

Sébastien Picard ◽

Dina Aggad ◽

Maxime Klausen ◽

Chiara Mauriello Jimenez ◽

...

Keyword(s):

Breast Cancer ◽

Photodynamic Therapy ◽

Click Chemistry ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Periodic Mesoporous Organosilica ◽

Two Photon ◽

Mesoporous Organosilica ◽

Photon Imaging ◽

In Cells

The synthesis of ethenylene-based periodic mesoporous organosilica nanoparticles for two-photon imaging and photodynamic therapy of breast cancer cells is described.

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Photodynamic activity of 2,6-dibrominated dimethylaminophenylbuta-1,3-dienylBODIPY dyes

Journal of Porphyrins and Phthalocyanines ◽

10.1142/s1088424620500509 ◽

2020 ◽

Vol 25 (01) ◽

pp. 47-55

Author(s):

Gugu Kubheka ◽

Balaji Babu ◽

Earl Prinsloo ◽

Nagao Kobayashi ◽

John Mack ◽

...

Keyword(s):

Breast Cancer ◽

Photodynamic Therapy ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Photodynamic Activity ◽

Depth Study ◽

Mcf 7

Mono- and disubstituted 2,6-dibromo-dimethylaminophenylbuta-1,3-dienylBODIPY dyes were successfully prepared, and their in vitro photodynamic activities against MCF-7 breast cancer cells were evaluated with a Thorlabs M660L4 660 nm LED (336 J · cm[Formula: see text]. The IC[Formula: see text] value of the monophenylbuta-1,3-dienylBODIPY was ca. 2.1 [Formula: see text]M, while that of the diphenylbuta-1,3-dienylBODIPY was > 50 [Formula: see text]M. Both dyes exhibited minimal dark toxicity. The results demonstrate that monosubstituted 2,6-dibromo-dimethylaminophenylbuta-1,3-dienylBODIPY dyes merit further in-depth study for use as photosensitizer dyes in photodynamic therapy.

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In vitro and in vivo effects of photodynamic therapy on metastatic breast cancer cells pre-treated with zoledronic acid

Photodiagnosis and Photodynamic Therapy ◽

10.1016/j.pdpdt.2014.04.002 ◽

2014 ◽

Vol 11 (3) ◽

pp. 426-433

Author(s):

Margarete K. Akens ◽

Lisa Wise-Milestone ◽

Emily Won ◽

Joerg Schwock ◽

Albert J.M. Yee ◽

...

Keyword(s):

Breast Cancer ◽

Photodynamic Therapy ◽

Metastatic Breast Cancer ◽

Zoledronic Acid ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Metastatic Breast ◽

In Vivo Effects

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Ruthenium(ii) complexes as bioorthogonal two-photon photosensitizers for tumour-specific photodynamic therapy against triple-negative breast cancer cells

Chemical Communications ◽

10.1039/d1cc00661d ◽

2021 ◽

Author(s):

Mingwei Lin ◽

Shanshan Zou ◽

Xinxing Liao ◽

Yu Chen ◽

Diqing Luo ◽

...

Keyword(s):

Breast Cancer ◽

Photodynamic Therapy ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Two Photon

We developed the first Ru(ii) complex-based bioorthogonal two-photon photosensitizers. Through bioorthogonal labelling, they realize effective tumour-specific photodynamic therapy against triple-negative breast cancer cells.

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