Metal-free sulfonyl radical-initiated cascade cyclization to access sulfonated indolo[1,2-a]quinolines

2019 ◽  
Vol 55 (84) ◽  
pp. 12615-12618 ◽  
Author(s):  
Kai Sun ◽  
Xiao-Lan Chen ◽  
Yin-Li Zhang ◽  
Kai Li ◽  
Xian-Qiang Huang ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Quinoline Derivatives ◽  
Metal Free ◽  
Cascade Cyclization

A metal-free cascade reaction was developed for the synthesis of indolo[1,2-a]quinoline derivatives from arylsulfonyl hydrazides and 1-(2-(arylethynyl)phenyl)indoles in the presence of TBAI/TBHP.

scholarly journals Metal-free synthesis of 1,N6-ethenoadenines from N6-propargyl-adenines via NIS mediated radical cascade reaction

RSC Advances ◽  
2019 ◽  
Vol 9 (66) ◽  
pp. 38897-38901
Author(s):  
Ruchun Yang ◽  
Si Deng ◽  
Xiang-you Dong ◽  
Xianrong Song ◽  
Hu Cai ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Metal Free ◽  
Efficient Approach ◽  
Cascade Cyclization ◽  
Radical Cascade

An efficient approach for the construction of 1,N6-ethenoadenines is developed through the metal-free mediated radical cascade cyclization of conveniently prepared N6-propargyl-adenines.

A metal-free yne-addition/1,4-aryl migration/decarboxylation cascade reaction of alkynoates with Csp3–H centers

2016 ◽  
Vol 14 (7) ◽  
pp. 2210-2217 ◽  
Author(s):  
De-Long Kong ◽  
Liang Cheng ◽  
Hong-Ru Wu ◽  
Yang-Xiong Li ◽  
Dong Wang ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Single Site ◽  
Metal Free ◽  
Different Types

Reactions of alkynoates with different types of radical precursors under metal-free conditions affording single-site-addition poly-substituted alkenes were reported.

A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

2021 ◽  
Author(s):  
Tao Fan ◽  
Yan Liu ◽  
Caina Jiang ◽  
Yanli Xu ◽  
Yan-Yan Chen
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Mild Conditions ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

Brønsted Acid-Catalyzed Solvent-Controlled Regioselective Hydrothiolation and Diastereoselective Cascade Cyclization of Dienes

2021 ◽  
Author(s):  
Kai Ji ◽  
Ka Lu ◽  
Jie Huang ◽  
Zi-Hao Li ◽  
Tong-Mei Ding ◽  
...  
Keyword(s):  
Free Atom ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Metal Free ◽  
Cascade Cyclization ◽  
Brönsted Acid ◽  
Acid Catalyzed ◽  
First Time

A highly regio- and diastereo-selective Brønsted acid-catalyzed tandem hydrothiolation/Friedel-Crafts reaction of linear 1,3-dienes has been developed for the first time, which provides a metal-free, atom-economic and concise way of constructing...

Catalytic Radical Cascade Cyclization of Alkene-Tethered Enones to Fused Bicyclic Cyclopropanols

2021 ◽  
Author(s):  
Ying Xie ◽  
Wei Huang ◽  
Song Qin ◽  
Shaomin Fu ◽  
Bo Liu
Keyword(s):  
Hydrogen Atom ◽  
Cascade Reaction ◽  
Hydrogen Atom Transfer ◽  
Atom Transfer ◽  
Trimethyl Borate ◽  
Cascade Cyclization ◽  
Radical Cascade ◽  
Privileged Scaffolds

An unprecedented hydrogen atom transfer-triggered intramolecular cascade reaction between alkene and enone is developed, using Fe(acac)3, PhSiH2(Oi-Pr) and trimethyl borate, to efficiently construct cis-fused bicyclic cyclopropanols, privileged scaffolds often found...

Diverse privileged N-polycyclic skeletons accessed from a metal-free cascade cyclization reaction

2021 ◽  
Vol 19 (37) ◽  
pp. 8086-8095
Author(s):  
Wenzhong Li ◽  
Yu Wang ◽  
Huijing Qi ◽  
Ran Shi ◽  
Jiazhu Li ◽  
...  
Keyword(s):  
Membered Ring ◽  
Cyclization Reaction ◽  
One Pot ◽  
Metal Free ◽  
Cascade Cyclization ◽  
One Pot Synthesis ◽  
Ring Compounds

Metal-free cascade cyclization of 2-acylbenzoic acids with amines provided a one-pot synthesis of diverse isoindoloisoquinoline and benzoindolizinoindole derivatives, which were subsequently used to produce nitrogen-containing nine-membered ring compounds.

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