Brønsted Acid-Catalyzed Solvent-Controlled Regioselective Hydrothiolation and Diastereoselective Cascade Cyclization of Dienes

A highly regio- and diastereo-selective Brønsted acid-catalyzed tandem hydrothiolation/Friedel-Crafts reaction of linear 1,3-dienes has been developed for the first time, which provides a metal-free, atom-economic and concise way of constructing...

A Simple and Efficient Metal Free, Additive or Base Free Dehydrogenation of Tetrahydroisoquinolines Using Oxygen as a Clean Oxidant

Metal free dehydrogenation of various substituted tetrahydroisoquinolines via a simple and convenient metal free, atom economical route for the synthesis of corresponding isoquinolines under oxygen atmosphere in N-methyl-2-pyrollidone (NMP) is described. Metal free dehydrogenation was carried out without the use of additive or base. A scope of the methodology was demonstrated for a number of aryl and heteroaryl susbstitution present at C1 position and ester moiety at C3 position and was found to be good substrates. Substituted isoquinolines (3a-3h) and their esters (3i-3m) were synthesized in very good to excellent yields.