Synergistic effects of dual-presenting VEGF- and BDNF-mimetic peptide epitopes from self-assembling peptide hydrogels on peripheral nerve regeneration

Nanoscale ◽  
2019 ◽  
Vol 11 (42) ◽  
pp. 19943-19958 ◽  
Author(s):  
Jiaju Lu ◽  
Xiaoqing Yan ◽  
Xun Sun ◽  
Xuezhen Shen ◽  
Heyong Yin ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Synergistic Effects ◽  
Peripheral Nerve Regeneration ◽  
Mimetic Peptide ◽  
Peptide Epitopes ◽  
Self Assembling ◽  
Peptide Hydrogels

We developed the functionalized self-assembling peptide nanofiber hydrogel RAD/KLT/RGI that was dual-functionalized with VEGF- and BDNF-mimetic peptide epitopes for peripheral nerve regeneration.

scholarly journals Self-assembling peptide hydrogels functionalized with LN- and BDNF- mimicking epitopes synergistically enhance peripheral nerve regeneration

Theranostics ◽  
2020 ◽  
Vol 10 (18) ◽  
pp. 8227-8249
Author(s):  
Shuhui Yang ◽  
Chong Wang ◽  
Jinjin Zhu ◽  
Changfeng Lu ◽  
Haitao Li ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Self Assembling ◽  
Peptide Hydrogels

scholarly journals Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury

Biomaterials ◽  
2021 ◽  
Vol 265 ◽  
pp. 120401
Author(s):  
Tania L. Lopez-Silva ◽  
Carlo D. Cristobal ◽  
Cheuk Sun Edwin Lai ◽  
Viridiana Leyva-Aranda ◽  
Hyun Kyoung Lee ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Crush Injury ◽  
Self Assembling ◽  
Peptide Hydrogels

TNF-mimetic peptide mixed with fibrin glue improves peripheral nerve regeneration

2021 ◽  
Vol 174 ◽  
pp. 53-62
Author(s):  
Tárika Gonçalves do Carmo Oliveira ◽  
Ana Cláudia Moreira dos Santos ◽  
Alex Dias Assis ◽  
Raphael Teixeira Borges ◽  
Jéssica Regina da Costa Silva ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibrin Glue ◽  
Peripheral Nerve Regeneration ◽  
Mimetic Peptide

scholarly journals Functional self-assembling peptide nanofiber hydrogel for peripheral nerve regeneration

2016 ◽  
Vol 4 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Xiaoli Wu ◽  
Liumin He ◽  
Wen Li ◽  
Heng Li ◽  
Wai-Man Wong ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Self Assembling

scholarly journals Bionic microenvironment-inspired synergistic effect of anisotropic micro-nanocomposite topology and biology cues on peripheral nerve regeneration

2021 ◽  
Vol 7 (28) ◽  
pp. eabi5812
Author(s):  
Guicai Li ◽  
Tiantian Zheng ◽  
Linliang Wu ◽  
Qi Han ◽  
Yifeng Lei ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Transforming Growth Factor ◽  
Synergistic Effects ◽  
Peripheral Nerve Regeneration ◽  
Transforming Growth Factor Β ◽  
Signal Pathways ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Promising Application

Anisotropic topographies and biological cues can simulate the regenerative microenvironment of nerve from physical and biological aspects, which show promising application in nerve regeneration. However, their synergetic influence on injured peripheral nerve is rarely reported. In the present study, we constructed a bionic microenvironment-inspired scaffold integrated with both anisotropic micro-nanocomposite topographies and IKVAV peptide. The results showed that both the topographies and peptide displayed good stability. The scaffolds could effectively induce the orientation growth of Schwann cells and up-regulate the genes and proteins relevant to myelination. Last, three signal pathways including the Wnt/β-catenin pathway, the extracellular signal–regulated kinase/mitogen-activated protein pathway, and the transforming growth factor–β pathway were put forward, revealing the main path of synergistic effects of anisotropic micro-nanocomposite topographies and biological cues on neuroregeneration. The present study may supply an important strategy for developing functional of artificial nerve implants.

Modern approaches to peripheral nerve regeneration after injury: the prospects of gene and cell therapy

2017 ◽  
Author(s):  
M. Karagyaur ◽  
P. Makarevich ◽  
E. Shevchenko ◽  
D. Stambolsky ◽  
N. Kalinina ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Gene And Cell Therapy
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