scholarly journals Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia

RSC Advances ◽  
2019 ◽  
Vol 9 (29) ◽  
pp. 16863-16868 ◽  
Author(s):  
Yui Umehara ◽  
Toki Kageyama ◽  
Aoi Son ◽  
Yu Kimura ◽  
Teruyuki Kondo ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Tumor Hypoxia ◽  
Biological Reduction ◽  
Selective Accumulation ◽  
Tumor Selective

Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging.

Macrophages-Mediated Delivery of Small Gold Nanorods for Tumor Hypoxia Photoacoustic Imaging and Enhanced Photothermal Therapy

2019 ◽  
Vol 11 (17) ◽  
pp. 15251-15261 ◽  
Author(s):  
Lu An ◽  
Yuanyuan Wang ◽  
Jiaomin Lin ◽  
Qiwei Tian ◽  
Yinxiao Xie ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Tumor Hypoxia

In vivo photoacoustic imaging with multiple selective targeting using bioconjugated gold nanorods

2008 ◽  
Author(s):  
Chen-Wei Wei ◽  
Chao-Kang Liao ◽  
Ying-Yi Chen ◽  
Churng-Ren Chris Wang ◽  
Ann-Ann Ding ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Selective Targeting

Enzyme-responsive copper sulphide nanoparticles for combined photoacoustic imaging, tumor-selective chemotherapy and photothermal therapy

2013 ◽  
Vol 49 (33) ◽  
pp. 3455 ◽  
Author(s):  
Zhengbao Zha ◽  
Shuhai Zhang ◽  
Zijian Deng ◽  
Yanyan Li ◽  
Changhui Li ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Copper Sulphide ◽  
Selective Chemotherapy ◽  
Tumor Selective

scholarly journals A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles

Oncotarget ◽  
2011 ◽  
Vol 2 (1-2) ◽  
pp. 59-68 ◽  
Author(s):  
Yuan Qiao ◽  
Xin Huang ◽  
Sridhar Nimmagadda ◽  
Renyuan Bai ◽  
Verena Staedtke ◽  
...  
Keyword(s):  
Robust Approach ◽  
Selective Accumulation ◽  
Tumor Selective

scholarly journals Photoacoustic molecular imaging using combined acupuncture and gold nanorods as a composite contrast agent

2019 ◽  
Vol 12 (03) ◽  
pp. 1941004
Author(s):  
Dan Wu ◽  
Xinxin Zhang ◽  
Jian Rong ◽  
Huabei Jiang
Keyword(s):  
Contrast Agent ◽  
Contrast Enhancement ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Local Concentration ◽  
Quantitative Results ◽  
Zusanli Acupoint

In this study, we developed a novel photoacoustic imaging technique based on poly (ethyleneglycol)-coated (PEGylated) gold nanorods (PEG-GNRs) (as the contrast agent) combined with traditional Chinese medicine (TCM) acupuncture (as the auxiliary method) for quantitatively monitoring contrast enhancement in the vasculature of a mouse brain in vivo. This study takes advantage of the strong near-infrared absorption (peak at [Formula: see text][Formula: see text]nm) of GNRs and the ability to adjust the hemodynamics of acupuncture. Experimental results show that photoacoustic tomography (PAT) successfully reveals the optical absorption variation of the vasculature of the mouse brain in response to intravenous administration of GNRs and acupuncture at the Zusanli acupoint (ST36) both individually and combined. The quantitative measurement of contrast enhancement indicates that the composite contrast agents (integration of acupuncture and GNRs) would greatly enhance the photoacoustic imaging contrast. The quantitative results also have the potential to estimate the local concentration of GNRs and even the real-time effects of acupuncture.

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