scholarly journals New insights on the supramolecular structure of highly porous core–shell drug nanocarriers using solid-state NMR spectroscopy

RSC Advances ◽  
2019 ◽  
Vol 9 (56) ◽  
pp. 32472-32475
Author(s):  
Marianna Porcino ◽  
Ioanna Christodoulou ◽  
Mai Dang Le Vuong ◽  
Ruxandra Gref ◽  
Charlotte Martineau-Corcos
Keyword(s):  
Drug Delivery ◽  
Solid State ◽  
Solid State Nmr ◽  
Metal Organic Frameworks ◽  
Core Shell ◽  
Porous Core ◽  
Engineered Surfaces ◽  
Metal Organic ◽  
Drug Nanocarriers ◽  
Highly Porous

Nano-sized metal–organic frameworks (nanoMOFs), with engineered surfaces to enhance the targeting of the drug delivery, have proven efficient as drug nanocarriers.

scholarly journals Doxorubicin-Loaded Metal-Organic Frameworks Nanoparticles with Engineered Cyclodextrin Coatings: Insights on Drug Location by Solid State NMR Spectroscopy

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 945
Author(s):  
Xue Li ◽  
Marianna Porcino ◽  
Jingwen Qiu ◽  
Doru Constantin ◽  
Charlotte Martineau-Corcos ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Metal Organic Frameworks ◽  
Deep Understanding ◽  
Core Shell ◽  
Main Role ◽  
Shell System ◽  
Metal Organic ◽  
Multiple Interactions ◽  
Do So

Recently developed, nanoscale metal-organic frameworks (nanoMOFs) functionalized with versatile coatings are drawing special attention in the nanomedicine field. Here we show the preparation of core–shell MIL-100(Al) nanoMOFs for the delivery of the anticancer drug doxorubicin (DOX). DOX was efficiently incorporated in the MOFs and was released in a progressive manner, depending on the initial loading. Besides, the coatings were made of biodegradable γ-cyclodextrin-citrate oligomers (CD-CO) with affinity for both DOX and the MOF cores. DOX was incorporated and released faster due to its affinity for the coating material. A set of complementary solid state nuclear magnetic resonance (ssNMR) experiments including 1H-1H and 13C-27Al two-dimensional NMR, was used to gain a deep understanding on the multiple interactions involved in the MIL-100(Al) core–shell system. To do so, 13C-labelled shells were synthesized. This study paves the way towards a methodology to assess the nanoMOF component localization at a molecular scale and to investigate the nanoMOF physicochemical properties, which play a main role on their biological applications.

Adsorption of Small Molecules on Cu3(btc)2 and Cu3–xZnx(btc)2 Metal–Organic Frameworks (MOF) As Studied by Solid-State NMR

2013 ◽  
Vol 117 (15) ◽  
pp. 7703-7712 ◽  
Author(s):  
Farhana Gul-E-Noor ◽  
Matthias Mendt ◽  
Dieter Michel ◽  
Andreas Pöppl ◽  
Harald Krautscheid ◽  
...  
Keyword(s):  
Solid State ◽  
Small Molecules ◽  
Solid State Nmr ◽  
Metal Organic Frameworks ◽  
Metal Organic

scholarly journals Temperature Treatment of Highly Porous Zirconium-Containing Metal–Organic Frameworks Extends Drug Delivery Release

2017 ◽  
Vol 139 (22) ◽  
pp. 7522-7532 ◽  
Author(s):  
Michelle H. Teplensky ◽  
Marcus Fantham ◽  
Peng Li ◽  
Timothy C. Wang ◽  
Joshua P. Mehta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Temperature Treatment ◽  
Metal Organic ◽  
Highly Porous

Spies Within Metal-Organic Frameworks: Investigating Metal Centers Using Solid-State NMR

2014 ◽  
Vol 118 (41) ◽  
pp. 23728-23744 ◽  
Author(s):  
Peng He ◽  
Bryan E. G. Lucier ◽  
Victor V. Terskikh ◽  
Qi Shi ◽  
Jinxiang Dong ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Metal Organic Frameworks ◽  
Metal Centers ◽  
Metal Organic
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