scholarly journals Sustained delivery of PlGF-2123-144*-fused BMP2-related peptide P28 from small intestinal submucosa/polylactic acid scaffold material for bone tissue regeneration

RSC Advances ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 7289-7300
Author(s):  
Zekang Xiong ◽  
Wei Cui ◽  
Tingfang Sun ◽  
Yu Teng ◽  
Yanzhen Qu ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Repair ◽  
Bone Tissue Regeneration ◽  
Sustained Delivery ◽  
Scaffold Material ◽  
Related Peptide ◽  
Small Intestinal ◽  
Segmental Bone ◽  
Intestinal Submucosa

Sustained delivery of PlGF-2123-144*-fused BMP2-related peptide P28 from SIS/PLA scaffold facilitate the adhesion, proliferation, and osteogenic differentiation of bone marrow stromal cells. This system effectively promotes segmental bone repair.

Growth of bone marrow stromal cells on small intestinal submucosa: an alternative cell source for tissue engineered bladder

2005 ◽  
Vol 96 (7) ◽  
pp. 1120-1125 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Hsueh-Kung Lin ◽  
Dominic Frimberger ◽  
Robert B. Epstein ◽  
Bradley P. Kropp
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Small Intestinal Submucosa ◽  
Marrow Stromal Cells ◽  
Cell Source ◽  
Small Intestinal ◽  
Intestinal Submucosa

Accelerated bone repair with the use of a synthetic BMP-2-derived peptide and bone-marrow stromal cells

2004 ◽  
Vol 72A (1) ◽  
pp. 77-82 ◽  
Author(s):  
Atsuhiro Saito ◽  
Yoshihisa Suzuki ◽  
Shin-Ichi Ogata ◽  
Chikara Ohtsuki ◽  
Masao Tanihara
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Repair ◽  
Marrow Stromal Cells

Chondrogenic Priming of Human Bone Marrow Stromal Cells: A Better Route to Bone Repair?

2008 ◽  
pp. 110306231138043 ◽  
Author(s):  
Eric Farrell ◽  
Olav P. van der Jagt ◽  
Wendy Koevoet ◽  
Nicole Kops ◽  
Christiaan J. van Manen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Repair ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow

Role of Bone Marrow Stromal Cells in Impaired Bone Repair from BRONJ Osseous Lesions

2017 ◽  
Vol 96 (5) ◽  
pp. 539-546 ◽  
Author(s):  
L.H. He ◽  
E. Xiao ◽  
J.G. An ◽  
Y. He ◽  
S. Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Repair ◽  
Early Stage ◽  
Central Area ◽  
Osteonecrosis Of The Jaw ◽  
Marrow Stromal Cells ◽  
Defect Repair

Treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has posed significant challenges to maxillofacial surgeons because of the poor repair of BRONJ bone defects. Moreover, the pathological mechanisms remain unclear. Bone marrow stromal cells (BMSCs) play key roles during bone repair and bone regeneration. However, the activities of BMSCs derived from BRONJ lesions and the BRONJ lesion boundary, as well as the roles of BMSCs in BRONJ defect repair, are poorly defined. In this study, we found that BMSCs from the central area of the osteonecrotic BRONJ region (center-BRONJ BMSCs) and the peripheral area at the recommended debridement boundary (peri-BRONJ BMSCs) had decreased proliferative ability, self-renewal capacity, and multidifferentiation capacities compared with control BMSCs. Osteoclast-inducing ability was also impaired in BRONJ BMSCs. All of these results suggested that the decreased activities of BRONJ BMSCs, even the BMSCs derived from the BRONJ lesion boundary, might be an important factor leading to insufficient bone repair of BRONJ lesions. This study offers early stage evidence for the use of marrow stromal cells in the treatment of BRONJ.

Tissue-Engineered Bone Repair of Sheep Cranial Defects with Autologous Bone Marrow Stromal Cells

2001 ◽  
Vol 12 (6) ◽  
pp. 586-593 ◽  
Author(s):  
Qingxin Shang ◽  
Zhuo Wang ◽  
Wei Liu ◽  
Yihui Shi ◽  
Lei Cui ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Repair ◽  
Autologous Bone Marrow ◽  
Marrow Stromal Cells ◽  
Autologous Bone
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