Optimization of electromagnetic hot spots in surface-enhanced Raman scattering substrates for an ultrasensitive drug assay of emergency department patients’ plasma

The Analyst ◽  
2020 ◽  
Vol 145 (23) ◽  
pp. 7662-7672
Author(s):  
Thakshila Liyanage ◽  
Adrianna N. Masterson ◽  
Sumon Hati ◽  
Greta Ren ◽  
Nicholas E. Manicke ◽  
...  
Keyword(s):  
Emergency Department ◽  
Raman Scattering ◽  
Hot Spots ◽  
Surface Enhanced Raman Scattering ◽  
Ultrasensitive Detection ◽  
Drug Assay ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Emergency Department Patients

Nanoplasmonic superlattice surface-enhanced Raman scattering substrates have been developed for an ultrasensitive detection of fentanyl and cocaine from patients’ plasma.

Binary “island” shaped arrays with high-density hot spots for surface-enhanced Raman scattering substrates

Nanoscale ◽  
2018 ◽  
Vol 10 (29) ◽  
pp. 14220-14229 ◽  
Author(s):  
Weidong Zhao ◽  
Shuyuan Xiao ◽  
Yuxian Zhang ◽  
Dong Pan ◽  
Jiahui Wen ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Hot Spots ◽  
Surface Enhanced Raman Scattering ◽  
High Density ◽  
Self Assembled Monolayer ◽  
Sers Substrates ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Self Assembled

The BISA with high-density hot spots as reproducible SERS substrates by combining an opal structure with self-assembled monolayer AuNPs is demonstrated.

scholarly journals Formation of Interstitial Hot-Spots Using the Reduced Gap-Size between Plasmonic Microbeads Pattern for Surface-Enhanced Raman Scattering Analysis

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 1046 ◽  
Author(s):  
Taeksu Lee ◽  
Sanghee Jung ◽  
Soongeun Kwon ◽  
Woochang Kim ◽  
Jinsung Park ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Hot Spots ◽  
Hybrid Approach ◽  
Chemical Deposition ◽  
Surface Enhanced Raman Scattering ◽  
Imprint Lithography ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Nano Imprint

To achieve an effective surface-enhanced Raman scattering (SERS) sensor with periodically distributed “hot spots” on wafer-scale substrates, we propose a hybrid approach combining physical nano-imprint lithography and a chemical deposition method to form a silver microbead array. Nano-imprint lithography (NIL) can lead to mass-production and high throughput, but is not appropriate for generating strong “hot-spots.” However, when we apply electrochemical deposition to an NIL substrate and the reaction time was increased to 45 s, periodical “hot-spots” between the microbeads were generated on the substrates. It contributed to increasing the enhancement factor (EF) and lowering the detection limit of the substrates to 4.40 × 106 and 1.0 × 10−11 M, respectively. In addition, this synthetic method exhibited good substrate-to-substrate reproducibility (RSD < 9.4%). Our research suggests a new opportunity for expanding the SERS application.

Sign in / Sign up

Export Citation Format

Share Document