Kaempferol from Penthorum chinense Pursh suppresses HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation in acetaminophen-induced hepatotoxicity

Yi-Chao Du; Li Lai; Hao Zhang; Fu-Rui Zhong; Huan-Li Cheng; Bao-Lin Qian; Peng Tan; Xian-Ming Xia; Wen-Guang Fu

doi:10.1039/d0fo00724b

Kaempferol from Penthorum chinense Pursh suppresses HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation in acetaminophen-induced hepatotoxicity

Food & Function ◽

10.1039/d0fo00724b ◽

2020 ◽

Vol 11 (9) ◽

pp. 7925-7934

Author(s):

Yi-Chao Du ◽

Li Lai ◽

Hao Zhang ◽

Fu-Rui Zhong ◽

Huan-Li Cheng ◽

...

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation ◽

Penthorum Chinense Pursh ◽

Penthorum Chinense

In this study, kaempferol (KA) ameliorates APAP-induced hepatotoxicity by activating HO-1/NQO1 and inhibiting HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation.

Download Full-text

248-LB: Deficiency of APPL1 in Macrophages Triggers Adipose Tissue Inflammation and Insulin Resistance by Potentiating NLRP3 Inflammasome Activation

Diabetes ◽

10.2337/db19-248-lb ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 248-LB ◽

Cited By ~ 1

Author(s):

KELVIN K.L. WU ◽

AIMIN XU ◽

KENNETH K. CHENG

Keyword(s):

Insulin Resistance ◽

Adipose Tissue ◽

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Adipose Tissue Inflammation ◽

Tissue Inflammation ◽

Nlrp3 Inflammasome Activation

Download Full-text

Faculty Opinions recommendation of Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717980435.793471692 ◽

2013 ◽

Author(s):

Laurel Lenz ◽

Rebecca Schmidt

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

Download Full-text

Faculty Opinions recommendation of Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718039111.793480657 ◽

2013 ◽

Author(s):

Douglas Green ◽

Jennifer Martinez

Keyword(s):

Fatty Acids ◽

Nlrp3 Inflammasome ◽

Metabolic Disorder ◽

Inflammasome Activation ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Nlrp3 Inflammasome Activation

Download Full-text

Faculty Opinions recommendation of 3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718184539.793519737 ◽

2016 ◽

Author(s):

Eicke Latz

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

Download Full-text

Faculty Opinions recommendation of Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726362863.793559823 ◽

2019 ◽

Author(s):

Paras Anand

Keyword(s):

Nlrp3 Inflammasome ◽

Dextran Sulfate ◽

Dextran Sulfate Sodium ◽

Experimental Colitis ◽

Dimethyl Fumarate ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

Download Full-text

Faculty Opinions recommendation of Hemin and cobalt protoporphyrin inhibit NLRP3 inflammasome activation by enhancing autophagy: A novel mechanism of inflammasome regulation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726766143.793523875 ◽

2016 ◽

Author(s):

Mark A Williams

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation ◽

Cobalt Protoporphyrin

Download Full-text

Faculty Opinions recommendation of Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734279765.793559839 ◽

2019 ◽

Author(s):

Paras Anand

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

Download Full-text

Faculty Opinions recommendation of PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734514948.793559815 ◽

2019 ◽

Author(s):

Paras Anand

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Trans Golgi Network ◽

Nlrp3 Inflammasome Activation ◽

Golgi Network

Download Full-text

Faculty Opinions recommendation of The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735165969.793559816 ◽

2019 ◽

Author(s):

Paras Anand

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Cysteine Cathepsins ◽

Nlrp3 Inflammasome Activation

Download Full-text

Carrageenan Triggers NLRP3 Inflammasome Activation and IL-1β Production by Macrophages

SSRN Electronic Journal ◽

10.2139/ssrn.3405570 ◽

2019 ◽

Author(s):

Alexandre H. Lopes ◽

Rangel L. Silva ◽

Miriam D. Fonseca ◽

Francisco I. Gomes ◽

Alexandre G. Maganin ◽

...

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

Download Full-text