scholarly journals High-throughput roll-to-roll production of polymer biochips for multiplexed DNA detection in point-of-care diagnostics

Lab on a Chip ◽  
2020 ◽  
Vol 20 (22) ◽  
pp. 4106-4117
Author(s):  
Pelin Toren ◽  
Martin Smolka ◽  
Anja Haase ◽  
Ursula Palfinger ◽  
Dieter Nees ◽  
...  

Roll-to-roll UV nanoimprint lithography has superior advantages for high-throughput manufacturing of micro- or nano-structures on flexible polymer foils with various geometries and configurations.


2020 ◽  
Vol 22 (4) ◽  
pp. 1901217 ◽  
Author(s):  
Marcos Soldera ◽  
Qiong Wang ◽  
Flavio Soldera ◽  
Valentin Lang ◽  
Antonio Abate ◽  
...  






2019 ◽  
Vol 5 (8) ◽  
pp. eaaw9906 ◽  
Author(s):  
Hnin Yin Yin Nyein ◽  
Mallika Bariya ◽  
Liisa Kivimäki ◽  
Sanna Uusitalo ◽  
Tiffany Sun Liaw ◽  
...  

Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes. To overcome this challenge, we introduce microfluidic sensing patches mass fabricated via roll-to-roll (R2R) processes. The patch allows sweat capture within a spiral microfluidic for real-time measurement of sweat parameters including [Na+], [K+], [glucose], and sweat rate in exercise and chemically induced sweat. The patch is demonstrated for investigating regional sweat composition, predicting whole-body fluid/electrolyte loss during exercise, uncovering relationships between sweat metrics, and tracking glucose dynamics to explore sweat-to-blood correlations in healthy and diabetic individuals. By enabling a comprehensive sweat analysis, the presented device is a crucial tool for advancing sweat testing beyond the research stage for point-of-care medical and athletic applications.



2014 ◽  
Vol 13 (4) ◽  
pp. 043003 ◽  
Author(s):  
Manuel W. Thesen ◽  
Dieter Nees ◽  
Stephan Ruttloff ◽  
Maximilian Rumler ◽  
Mathias Rommel ◽  
...  


2017 ◽  
Vol 87 ◽  
pp. 686-692 ◽  
Author(s):  
Li-Ju Wang ◽  
Yu-Chung Chang ◽  
Rongrong Sun ◽  
Lei Li


2013 ◽  
Vol 112 ◽  
pp. 273-277 ◽  
Author(s):  
Hiroshi Yoshikawa ◽  
Jun Taniguchi ◽  
Go Tazaki ◽  
Toshiyuki Zento




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