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Quinolines are nitrogen heterocyclic compounds ubiquitous in nature and largely used as a structural
component of dyes, solvent for resins, terpenes as well as during the production of several other chemical stuffs, including
pesticides. Quinolines, such as quinine and chloroquine, exhibit various pharmacological properties, acting as antimalarial
drugs, antiparasitic, antibacterial, antiviral, antifungal, and anticancer agents, besides being in clinical use for autoimmune
diseases. Presently, a brief review is present regarding the biological effect and clinical use of quinolines and derivatives
upon two trypanosomatids agents of important neglected tropical diseases; Trypanosoma cruzi, Trypanosoma brucei spp
and Leishmania spp, which trigger Chagas disease, sleeping sickness and leishmaniasis, respectively, also extending to a
glance update of their potential application towards other microbes relevant for emerging illness caused by fungi, bacteria
and virus, including the pandemic Covid-19.