Efficient suppression of amyloid-β peptide aggregation and cytotoxicity with photosensitive polymer nanodots

2020 ◽  
Vol 8 (26) ◽  
pp. 5776-5782 ◽  
Author(s):  
Yueling Xu ◽  
Lehui Xiao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Aβ Peptides ◽  
Efficient Suppression ◽  
Photosensitive Polymer ◽  
Aβ Aggregation

The aggregation of amyloid-β (Aβ) peptides is closely related to Alzheimer's disease (AD). These functionalized Pdots manifest effective photo-triggered suppression ability for the Aβ aggregation and cytotoxicity under irradiation.

A theoretical study on the molecular determinants of the affibody protein ZAβ3bound to an amyloid β peptide

2015 ◽  
Vol 17 (26) ◽  
pp. 16886-16893 ◽  
Author(s):  
Xu Wang ◽  
Xianqiang Sun ◽  
Guanglin Kuang ◽  
Hans Ågren ◽  
Yaoquan Tu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Theoretical Study ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Aβ Peptides ◽  
Molecular Determinants

The investigation of the (ZAβ3)2:Aβ complex highlights the energetic contribution of affibody residues to the binding with alzheimer's disease associated Aβ peptides.

Computational models explain how copper binding to amyloid-β peptide oligomers enhances oxidative pathways

2019 ◽  
Vol 21 (17) ◽  
pp. 8774-8784 ◽  
Author(s):  
Giovanni La Penna ◽  
Mai Suan Li
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Computational Models ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Copper Binding ◽  
Aβ Peptides ◽  
Intrinsically Disordered ◽  
Disordered Peptides

Amyloid-β (Aβ) peptides are intrinsically disordered peptides and their aggregation is the major hallmark of Alzheimer's disease (AD) development.

scholarly journals Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

Brain ◽  
2014 ◽  
Vol 137 (3) ◽  
pp. 887-903 ◽  
Author(s):  
Ajeet Rijal Upadhaya ◽  
Irina Kosterin ◽  
Sathish Kumar ◽  
Christine A. F. von Arnim ◽  
Haruyasu Yamaguchi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Brain ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Preclinical Alzheimer’S Disease

scholarly journals Posttranslational Nitro-Glycative Modifications of Albumin in Alzheimer's Disease: Implications in Cytotoxicity and Amyloid-β Peptide Aggregation

2014 ◽  
Vol 40 (3) ◽  
pp. 643-657 ◽  
Author(s):  
Eva Ramos-Fernández ◽  
Marta Tajes ◽  
Ernest Palomer ◽  
Gerard ILL-Raga ◽  
Mònica Bosch-Morató ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation

Recent advances in the design and applications of amyloid-β peptide aggregation inhibitors for Alzheimer’s disease therapy

2019 ◽  
Vol 11 (6) ◽  
pp. 901-925 ◽  
Author(s):  
Safura Jokar ◽  
Saeedeh Khazaei ◽  
Hossein Behnammanesh ◽  
Amir Shamloo ◽  
Mostafa Erfani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Recent Advances ◽  
Disease Therapy ◽  
Aggregation Inhibitors
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