Base-Promoted Domino Reaction of 5-Substituted 2-Nitrosophenols with Bromomethyl Aryl Ketones: A Transition-Metal-Free Approach to 2-Aroylbenzoxazoles

2015 ◽  
Vol 80 (21) ◽  
pp. 10829-10837 ◽  
Author(s):  
Nayyef Aljaar ◽  
Chandi C. Malakar ◽  
Jürgen Conrad ◽  
Uwe Beifuss
Keyword(s):  
Transition Metal ◽  
Domino Reaction ◽  
Metal Free ◽  
Aryl Ketones

Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

2021 ◽  
Author(s):  
Penghui Dong ◽  
Kashif Majeed ◽  
lingna Wang ◽  
Zijian Guo ◽  
Fengtao Zhou ◽  
...  
Keyword(s):  
Transition Metal ◽  
Aldol Condensation ◽  
Domino Reaction ◽  
Tandem Reaction ◽  
Metal Free ◽  
Successive Formation ◽  
General Synthesis

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds...

Transition-Metal-Free, Intermolecular Azidoheteroarylation of Alkenes: Efficient Access to β-Azidoalkylated Quinoxalinones and Preliminary Antifungal Evaluation Against Magnaporthe grisea

Synthesis ◽  
2020 ◽  
Vol 52 (16) ◽  
pp. 2395-2409
Author(s):  
Weiwei Qin ◽  
Zhaodong Li ◽  
Yiming Du ◽  
Yue Chen ◽  
Yun-Lin Liu
Keyword(s):  
Transition Metal ◽  
Magnaporthe Grisea ◽  
Single Step ◽  
Domino Reaction ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Efficient Access ◽  
First Time ◽  
Antibacterial Evaluation ◽  
Addition Pathway

An efficient, PhI(OAc)2-mediated, radical azidoheteroarylation of alkenes under transition-metal-free conditions is reported by employing TMSN3 and quinoxalin-2(1H)-ones as coupling partners. This domino reaction allows an efficient synthesis of valuable orangoazides containing quinoxalin-2(1H)-one derivatives and could be extended to phosphinyl-alkylated quinoxalin-2(1H)-one in a single step in moderate to excellent yields under mild conditions, as demonstrated by the preliminary antibacterial evaluation against Magnaporthe grisea for the first time. Mechanistic studies revealed that this transformation undergoes a cascade addition pathway controlled by a polar radical.

ChemInform Abstract: Transition-Metal-Free α-Arylation of Enolizable Aryl Ketones and Mechanistic Evidence for a Radical Process.

ChemInform ◽  
2016 ◽  
Vol 47 (4) ◽  
pp. no-no
Author(s):  
Martin Pichette Drapeau ◽  
Indira Fabre ◽  
Laurence Grimaud ◽  
Ilaria Ciofini ◽  
Thierry Ollevier ◽  
...  
Keyword(s):  
Transition Metal ◽  
Radical Process ◽  
Metal Free ◽  
Aryl Ketones

Transition metal-free synthesis of α-aryl ketones via oxyallyl cation capture with arylboronic acids

2020 ◽  
Vol 7 (17) ◽  
pp. 2480-2485 ◽  
Author(s):  
Wei-Hua Huang ◽  
Gong-Bin Huang ◽  
Wen-Run Zhu ◽  
Jiang Weng ◽  
Gui Lu
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
Arylboronic Acids ◽  
Aryl Ketones ◽  
Substrate Tolerance ◽  
Oxyallyl Cation

α-Arylated ketones were accessed via oxyallyl cation capture with arylboronic acids in good yields with broad substrate tolerance.

Transition-metal-free C–C σ-bond activation of α-aryl ketones and subsequent Zn-catalyzed intramolecular cyclization: synthesis of tetrasubstituted furans

2019 ◽  
Vol 17 (10) ◽  
pp. 2725-2733 ◽  
Author(s):  
Yang Yuan ◽  
Hailu Tan ◽  
Lingkai Kong ◽  
Zhong Zheng ◽  
Murong Xu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Bond Activation ◽  
Metal Free ◽  
Aryl Ketones ◽  
Single Bonds

Atom-economical synthesis of tetrasubstituted furans from α-aryl ketones and alkynones through base-promoted cleavage of unstrained C–C single bonds of ketones and subsequent Zn-catalyzed cyclization.

Transition-Metal-Free α-Arylation of Enolizable Aryl Ketones and Mechanistic Evidence for a Radical Process

2015 ◽  
Vol 127 (36) ◽  
pp. 10733-10737 ◽  
Author(s):  
Martin Pichette Drapeau ◽  
Indira Fabre ◽  
Laurence Grimaud ◽  
Ilaria Ciofini ◽  
Thierry Ollevier ◽  
...  
Keyword(s):  
Transition Metal ◽  
Radical Process ◽  
Metal Free ◽  
Aryl Ketones

scholarly journals Transition-Metal-Free α-Arylation of Enolizable Aryl Ketones and Mechanistic Evidence for a Radical Process

2015 ◽  
Vol 54 (36) ◽  
pp. 10587-10591 ◽  
Author(s):  
Martin Pichette Drapeau ◽  
Indira Fabre ◽  
Laurence Grimaud ◽  
Ilaria Ciofini ◽  
Thierry Ollevier ◽  
...  
Keyword(s):  
Transition Metal ◽  
Radical Process ◽  
Metal Free ◽  
Aryl Ketones
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