Synergistic Cu/Pd-Catalyzed Asymmetric Allylation: A Facile Access to α-Quaternary Cysteine Derivatives

2021 ◽  
Author(s):  
Hui-Min Wu ◽  
Zongpeng Zhang ◽  
Liang Wei ◽  
Xiu-Qin Dong ◽  
Chun-Jiang Wang
Keyword(s):  
Asymmetric Allylation ◽  
Synthetic Methodology ◽  
Asymmetric Catalytic

An efficient synthetic methodology to access biologically important and synthetically useful α-quaternary cysteine derivatives via asymmetric catalytic α-allylation of readily available 2-thiazoline-4-carboxylates was successfully developed through the synergistic Cu/Pd catalytic...

Fentanyl Synthetic Methodology: A Comparative Study

1992 ◽  
Author(s):  
Fu-Lian Hsu ◽  
Harold D. Banks
Keyword(s):  
Comparative Study ◽  
Synthetic Methodology

Recent Developments in the Asymmetric Detrifluoroacetylative Reactions of in situ Generated Mono-Fluorinated Enolates

2020 ◽  
Vol 24 (18) ◽  
pp. 2181-2191
Author(s):  
Li Wang ◽  
Ziyi Li ◽  
Jiang Liu ◽  
Jianlin Han ◽  
Hiroki Moriwaki ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Bond Cleavage ◽  
Synthetic Methodology ◽  
Research Topics ◽  
Synthetic Organic Chemistry ◽  
Nucleophilic Reactions ◽  
F Center ◽  
Recent Developments

The development of an efficient and mild synthetic methodology for the construction of bioactive fluorine-containing molecules represents one of the hot research topics in general synthetic organic chemistry. In this review, some recent progresses achieved in the development of detrifluoroacetylatively generated mono-fluorinated enolates via CC bond cleavage and their asymmetric nucleophilic reactions for assembly of chiral quaternary C-F center containing compounds.

Synthesis of Pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by Alkyne-Carbonyl Metathesis

Synthesis ◽  
2020 ◽  
Author(s):  
Peter Ehlers ◽  
Peter Langer ◽  
Marian Blanco Ponce ◽  
Silvio Parpart ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Metathesis Reaction ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Modular Synthesis

AbstractA concise and modular synthesis of pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by a one-pot two-step reaction consisting of electrophilic acylation followed by an alkyne-carbonyl-metathesis reaction as the final cyclization step is reported. This developed synthetic methodology allows the facile synthesis of these heterocyclic core structures in mainly high overall yields under metal-free conditions. Reaction conditions are carefully optimized and display a novel supplement to access these tricyclic heterocyclic compounds.

scholarly journals Recent Advances in Organometallic Chemistry and Catalysis

Catalysts ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 646
Author(s):  
Victorio Cadierno
Keyword(s):  
Organic Chemistry ◽  
Organometallic Chemistry ◽  
Organometallic Compounds ◽  
Synthetic Methodology ◽  
Recent Advances

The use of organometallic compounds in organic chemistry is one of the cornerstones of the modern synthetic methodology for the activation and generation of new bonds in a molecule [...]

ChemInform Abstract: Synthetic Methodology for the Preparation of trans- and cis-2,9-Disubstituted Oxonanes.

ChemInform ◽  
1990 ◽  
Vol 21 (23) ◽  
Author(s):  
R. W. CARLING ◽  
N. R. CURTIS ◽  
A. B. HOLMES
Keyword(s):  
Synthetic Methodology
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