Rational design of self-assembled surfactant film in nanopipettes: a combined fluorescence and electrochemical sensing

2022 ◽  
Author(s):  
Qi Liu ◽  
Shushu Ding ◽  
Guoyue Shi ◽  
Anwei Zhu
Keyword(s):  
Rational Design ◽  
Ionic Current ◽  
Electrochemical Sensing ◽  
Fluorescent Analysis ◽  
Surfactant Film ◽  
Self Assembled

Herein, a generalizable method based on the formation of self-assembled surfactant film was reported to build a nanopipette system, which was applicable for both ionic current and fluorescent analysis of...

Electrochemical detection of adenine and guanine using a self-assembled copper(ii)–thiophenyl-azo-imidazole complex monolayer modified gold electrode

RSC Advances ◽  
2014 ◽  
Vol 4 (91) ◽  
pp. 49819-49826 ◽  
Author(s):  
Koushik Barman ◽  
Sk Jasimuddin
Keyword(s):  
Electrochemical Detection ◽  
Gold Electrode ◽  
Electrochemical Sensing ◽  
Self Assembled

A self-assembled copper(ii)–thiophenyl-azo-imidazole complex monolayer modified gold electrode exhibits an excellent electrochemical sensing ability towards adenine and guanine at physiological pH.

Rational Design of a Tetrameric Protein to Enhance Interactions between Self-Assembled Fibers Gives Molecular Hydrogels

2012 ◽  
Vol 51 (18) ◽  
pp. 4388-4392 ◽  
Author(s):  
Xiaoli Zhang ◽  
Xinlei Chu ◽  
Ling Wang ◽  
Huaimin Wang ◽  
Gaolin Liang ◽  
...  
Keyword(s):  
Rational Design ◽  
Self Assembled

Multilevel Molecular Modeling Approach for a Rational Design of Ionic Current Sensors for Nanofluidics

2018 ◽  
Vol 14 (6) ◽  
pp. 3113-3120 ◽  
Author(s):  
Alexsandro Kirch ◽  
James M. de Almeida ◽  
Caetano R. Miranda
Keyword(s):  
Molecular Modeling ◽  
Rational Design ◽  
Ionic Current ◽  
Modeling Approach ◽  
Current Sensors

scholarly journals Rational Design of Amphiphilic Diblock Copolymer/MWCNT Surface Modifiers and Their Application for Direct Electrochemical Sensing of DNA

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1514
Author(s):  
Larisa V. Sigolaeva ◽  
Tatiana V. Bulko ◽  
Apollinariya Yu. Konyakhina ◽  
Alexey V. Kuzikov ◽  
Rami A. Masamrekh ◽  
...  
Keyword(s):  
Electrochemical Oxidation ◽  
Diblock Copolymer ◽  
Rational Design ◽  
Diblock Copolymers ◽  
Aqueous Media ◽  
Electrochemical Sensing ◽  
Multiwalled Carbon ◽  
Surface Areas ◽  
Copolymer Structure ◽  
Great Acceleration

We demonstrate the application of amphiphilic ionic poly(n-butylmethacrylate)-block- poly(2-(dimethylamino)ethyl methacrylate) diblock copolymers (PnBMA40-b-PDMAEMA40, PnBMA40-b-PDMAEMA120, PnBMA70-b-PDMAEMA120) for dispersing multiwalled carbon nanotubes (MWCNTs) in aqueous media, a subsequent efficient surface modification of screen-printed electrodes (SPEs), and the application of the modified SPEs for DNA electrochemistry. Stable and fine aqueous dispersions of MWCNTs were obtained with PnBMAx-b-PDMAEMAy diblock copolymers, regardless of the structure of the copolymer and the amount of MWCNTs in the dispersions. The effect of the diblock copolymer structure was important when the dispersions of MWCNTs were deposited as modifying layers on surfaces of SPEs, resulting in considerable increases of the electroactive surface areas and great acceleration of the electron transfer rate. The SPE/(PnBMAx-b-PDMAEMAy + MWCNT) constructs were further exploited for direct electrochemical oxidation of the guanine (G) and adenine (A) residues in a model salmon sperm double-stranded DNA (dsDNA). Two well-defined irreversible oxidation peaks were observed at about +600 and +900 mV, corresponding to the electrochemical oxidation of G and A residues, respectively. A multi-parametric optimization of dsDNA electrochemistry enables one to get the limits of detection (LOD) as low as 5 μg/mL (0.25 μM) and 1 μg/mL (0.05 μM) for G and A residues, respectively. The achieved sensitivity of DNA assay enables quantification of the A and G residues of dsDNA in the presence of human serum and DNA in isolated human leukocytes.

Self-Assembled Monolayers of Mono-Tetrathiafulvalene Calix[4]pyrroles and Their Electrochemical Sensing of Chloride

2009 ◽  
Vol 15 (33) ◽  
pp. 8128-8133 ◽  
Author(s):  
Lise G. Jensen ◽  
Kent A. Nielsen ◽  
Tony Breton ◽  
Jonathan L. Sessler ◽  
Jan O. Jeppesen ◽  
...  
Keyword(s):  
Electrochemical Sensing ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Self Assembled

scholarly journals Reorganization of Self-Assembled DNA-Based Polymers Using Orthogonally Addressable Building Blocks

2021 ◽  
Author(s):  
Serena Gentile ◽  
Erica Del Grosso ◽  
Leonard J. Prins ◽  
Francesco Ricci
Keyword(s):  
Self Assembly ◽  
Rational Design ◽  
Building Blocks ◽  
Binding Domain ◽  
Non Covalent Interactions ◽  
Sticky Ends ◽  
Self Assembled ◽  
Block Structures ◽  
Covalent Interactions

Taking advantage of the addressability and programmability of DNA/DNA non-covalent interactions we report here the rational design of orthogonal DNA-based addressable tiles that self-assemble into polymer-like structures that can be reconfigured and reorganized by external inputs. The different tiles share the same 5-nucleotide sticky ends responsible for self-assembly but are rationally designed to contain a specific regulator-binding domain that can be orthogonally targeted by different DNA regulator strands (activators and inhibitors). We show that by sequentially adding specific activators and inhibitors it is possible to re-organize in a dynamic and reversible way the formed polymer-like structures to display well-defined distributions: homopolymers made of a single tile, random polymers in which different tiles are distributed randomly and block structures in which the tiles are organized in segments.

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