Biofunctionality with a twist: the importance of molecular organisation, handedness and configuration in synthetic biomaterial design

2021 ◽  
Author(s):  
Simone I. S. Hendrikse ◽  
Rafael Contreras-Montoya ◽  
Amanda V. Ellis ◽  
Pall Thordarson ◽  
Jonathan W. Steed
Keyword(s):  
Spatial Configuration ◽  
Synthetic Biomaterial ◽  
Molecular Organisation

This review highlights the importance of incorporating molecular organisation, spatial configuration and handedness in biomaterial design to arrive at improved native biomolecule interactions.

The Effect of Nonlinear Amplitude Growth on the Speech Perception Benefits Provided by a Single-Sided Vocoder

2019 ◽  
Vol 62 (3) ◽  
pp. 745-757 ◽  
Author(s):  
Jessica M. Wess ◽  
Joshua G. W. Bernstein
Keyword(s):  
Transfer Functions ◽  
Spatial Configuration ◽  
Free Field ◽  
Spatial Separation ◽  
Compression And Expansion ◽  
Interaural Difference ◽  
Interaural Differences ◽  
Single Sided Deafness ◽  
Perceptual Separation ◽  
Loudness Growth

PurposeFor listeners with single-sided deafness, a cochlear implant (CI) can improve speech understanding by giving the listener access to the ear with the better target-to-masker ratio (TMR; head shadow) or by providing interaural difference cues to facilitate the perceptual separation of concurrent talkers (squelch). CI simulations presented to listeners with normal hearing examined how these benefits could be affected by interaural differences in loudness growth in a speech-on-speech masking task.MethodExperiment 1 examined a target–masker spatial configuration where the vocoded ear had a poorer TMR than the nonvocoded ear. Experiment 2 examined the reverse configuration. Generic head-related transfer functions simulated free-field listening. Compression or expansion was applied independently to each vocoder channel (power-law exponents: 0.25, 0.5, 1, 1.5, or 2).ResultsCompression reduced the benefit provided by the vocoder ear in both experiments. There was some evidence that expansion increased squelch in Experiment 1 but reduced the benefit in Experiment 2 where the vocoder ear provided a combination of head-shadow and squelch benefits.ConclusionsThe effects of compression and expansion are interpreted in terms of envelope distortion and changes in the vocoded-ear TMR (for head shadow) or changes in perceived target–masker spatial separation (for squelch). The compression parameter is a candidate for clinical optimization to improve single-sided deafness CI outcomes.

Effects of spatial configuration on search of visual displays.

1980 ◽  
Author(s):  
Lauritz Braennstroem
Keyword(s):  
Spatial Configuration ◽  
Visual Displays

Integration of Spatial Configuration of Multiple Landmarks by Pigeons

2011 ◽  
Author(s):  
Tomokazu Ushitani ◽  
Masako Jitsumori
Keyword(s):  
Spatial Configuration

Distinctive spatial configuration of a class of microwave flaring sources

2003 ◽  
Vol 32 (12) ◽  
pp. 2497-2502
Author(s):  
M KUNDU ◽  
V GARAIMOV
Keyword(s):  
Spatial Configuration

The Spatial Configuration of Hanzi/Hanja/Kanji/chữ Nôm, a New Analytical Model

2019 ◽  
Vol 1 (1) ◽  
pp. 61-78
Author(s):  
Chen Ya Huang ◽  
Keyword(s):  
Analytical Model ◽  
Spatial Configuration

Study of the electrical grid spatial configuration with satellite images

2016 ◽  
Vol 909 (3) ◽  
pp. 50-55 ◽  
Author(s):  
P.E. Kargashin ◽  
◽  
B.A. Novakovskiy ◽  
A.I. Prasolova ◽  
A.M. Karpachevskiy ◽  
...  
Keyword(s):  
Satellite Images ◽  
Spatial Configuration ◽  
Electrical Grid

Approach to spatial modeling of networks and groups of objects on the basis of the weighted graph construction procedure

2020 ◽  
Vol 964 (10) ◽  
pp. 49-58
Author(s):  
V.I. Bilan ◽  
A.N. Grigor’ev ◽  
G.G. Dmitrikov ◽  
E.A. Dudin
Keyword(s):  
Spatial Configuration ◽  
Weighted Graph ◽  
Edge Length ◽  
Buffer Zones ◽  
Typical Structure ◽  
Spatial Graph ◽  
Object Based ◽  
Complementary Graph ◽  
Spatial Parameters ◽  
The Given

The direction of research on the development of a scientific and methodological tool for the analysis of spatial objects in order to determine their generalized spatial parameters was selected. An approach to the problem of modeling networks and groups of objects based on the synthesis of a weighted graph is proposed. The spatial configuration of objects based on the given conditions is described by a weighted graph, the edge length of which is considered as the weight of the edges. A generalization to the typical structure of a spatial graph is formulated; its essence is representation of nodal elements as two-dimensional (polygonal) objects. To take into account the restrictions on the convergence of the vertices described by the buffer zones, a complementary graph is formed. An algorithm for constructing the implementation of a spatial object based on the sequential determination of vertices that comply with the given conditions is proposed. Using the software implementation of the developed algorithm, an experiment was performed to evaluate the spatial parameters of the simulated objects described by typical graph structures. The following parameters were investigated as spatial ones

Patronage of urban commercial clusters: A network-based extension of the Huff model for balancing location and size

2017 ◽  
Vol 45 (3) ◽  
pp. 508-528 ◽  
Author(s):  
Andres Sevtsuk ◽  
Raul Kalvo
Keyword(s):  
Spatial Configuration ◽  
Analysis Tool ◽  
Spatial Networks ◽  
Urban Network ◽  
Household Level ◽  
New Town ◽  
New Towns ◽  
Public Facilities ◽  
User Access ◽  
Retail Demand

We introduce a version of the Huff retail expenditure model, where retail demand depends on households’ access to retail centers. Household-level survey data suggest that total retail visits in a system of retail centers depends on the relative location pattern of stores and customers. This dependence opens up an important question—could overall visits to retail centers be increased with a more efficient spatial configuration of centers in planned new towns? To answer this question, we implement the model as an Urban Network Analysis tool in Rhinoceros 3D, where facility patronage can be analyzed along spatial networks and apply it in the context of the Punggol New Town in Singapore. Using fixed household locations, we first test how estimated store visits are affected by the assumption of whether shoppers come from homes or visit shops en route to local public transit stations. We then explore how adjusting both the locations and sizes of commercial centers can maximize overall visits, using automated simulations to test a large number of scenarios. The results show that location and size adjustments to already planned retail centers in a town can yield a 10% increase in estimated store visits. The methodology and tools developed for this analysis can be extended to other context for planning and right-sizing retail developments and other public facilities so as to maximize both user access and facilities usage.

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