Effects of oral Vitamin D supplementation on inflammatory bowel disease: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yiwen Guo ◽  
Tao Zhang ◽  
Yandan Wang ◽  
Ruijie Liu ◽  
Ming Chang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bowel Disease ◽  
Effective Properties ◽  
Meta Analysis ◽  
Critical Role ◽  
Vitamin D Supplementation ◽  
Oral Vitamin ◽  
Inflammatory Bowel

Vitamin D (VitD) is a fat-soluble micronutrient that plays a critical role in inflammatory bowel disease (IBD). Although the effective properties of VitD in anti-inflammatory and immune moderation were reviewed,...

Risk Factors for Vitamin D Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 32 (6) ◽  
pp. 508-518
Author(s):  
Shanzhen Shi ◽  
◽  
Jiaxing Feng ◽  
Lixiang Zhou ◽  
Yu Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Inflammatory Bowel

scholarly journals Managing vitamin D deficiency in inflammatory bowel disease

2019 ◽  
Vol 10 (4) ◽  
pp. 394-400 ◽  
Author(s):  
Ole Haagen Nielsen ◽  
Thomas Irgens Hansen ◽  
John Mark Gubatan ◽  
Kim Bak Jensen ◽  
Lars Rejnmark
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Therapeutic Strategy ◽  
Critical Role ◽  
Vitamin D Supplementation ◽  
Disease Outcomes ◽  
Immunological Effects ◽  
Inflammatory Bowel

Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.

Systematic review with meta-analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease

2019 ◽  
Vol 50 (11-12) ◽  
pp. 1146-1158 ◽  
Author(s):  
John Gubatan ◽  
Naomi D. Chou ◽  
Ole Haagen Nielsen ◽  
Alan C. Moss
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Clinical Outcomes ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Adult Patients ◽  
Vitamin D Status ◽  
Inflammatory Bowel

P.07.11 ASSOCIATION BETWEEN INFLAMMATORY BOWEL DISEASE AND VITAMIN D DEFICIENCY: A SYSTEMATIC REVIEW AND META-ANALYSIS

2016 ◽  
Vol 48 ◽  
pp. e161 ◽  
Author(s):  
R. Del Pinto ◽  
D. Pietropaoli ◽  
A.K. Chandar ◽  
C. Ferri ◽  
F. Cominelli
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Inflammatory Bowel

scholarly journals P700 Effect of vitamin D in disease activity score and clinical relapse in patients with inflammatory bowel disease: A systematic review and meta-analysis

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S567-S568
Author(s):  
Y Guzman ◽  
O Samson ◽  
J P Segal ◽  
J K Limdi ◽  
B Hayee
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Disease Activity ◽  
Relapse Rate ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Clinical Relapse ◽  
Insufficient Data ◽  
Inflammatory Bowel

Abstract Background Vitamin D deficiency has been reported as highly prevalent among patients with inflammatory bowel disease (IBD) and current studies have demonstrated an association between low vitamin D status and an increased risk of clinically active disease, mucosal inflammation and clinical relapse. The aim of our study was to conduct a systematic review and meta-analysis exploring the effect of vitamin D supplementation in clinical and biochemical disease activity scores and relapse rate in patients with IBD. Methods We performed a search of major electronic databases (MEDLINE, EMBASE, Cochrane Library) and sources for grey literature (GreyNet international, Google Scholar, Web of Science) from inception to October 2019. Our search strategy was limited to the English and Spanish language. The results were supplemented by a manual search of the bibliographies of the shortlisted review and original study articles. Inclusion criteria: Adults (over 18 years old) with IBD (ulcerative colitis or Crohn’s disease); interventional (RCTs or non-RCTs) or observational studies; studies assessed the effect of vitamin D supplementation on disease activity scores and relapse rate. Exclusion criteria: Reviews, case reports, editorial, comment, letters; duplicates studies; insufficient data or unable to calculate outcome measures with available data. Mean difference was considered as the effect measure with 95% confidence interval (95% CI) and two sided P values. For relapse rate outcome, unadjusted OR were calculated using dichotomous data (events vs. total). Heterogeneity was assessed using χ2 test and I2 statistic. Review Manager software v.5.3 was used. Results A meta-analysis of five studies (n = 253) showed a lower relapse rate in vitamin D supplementation group compared with control group (OR: 0.33, 95% CI 0.18–0.61, p =  0.0004, I2: 0%) (Figure 1). Harvey Bradshaw Index improved by 1.52 points (95% CI: 0.14–2.90, p = 0.03, I2 51%) in vitamin D group compared with the score at baseline and C-reactive protein levels decreased compared with the levels at baseline (mean difference: 3.70 mg/l, 95% CI 0.10–7.29, p = 0.04, I2 0%) (Figures 2 and 3). Even though other studies reported different clinical remission tools such as SCCAI or CDAI, it was not possible to pool the results due to insufficient data to conduct a meta-analysis. Conclusion Our systematic review and meta-analysis provides evidence that vitamin D supplementation can improve clinical outcomes and reduce relapse rate in patients with IBD.

scholarly journals P787 Vitamin D status and clinical outcomes in inflammatory bowel disease patients: a systematic review and meta-analysis

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S515-S515
Author(s):  
J M Gubatan ◽  
N D Chou ◽  
O H Nielsen ◽  
A C Moss
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Clinical Outcomes ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Vitamin D Status ◽  
Inflammatory Bowel

Fr546 INTERVENTIONS TO INCREASE VACCINATIONS RATES WITH INFLAMMATORY BOWEL DISEASE AND RHEUMATOID ARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

2021 ◽  
Vol 160 (6) ◽  
pp. S-357
Author(s):  
Jalpa Patel ◽  
Dina Fakhouri ◽  
Mohamed Noureldin ◽  
Iris Kovar-Gough ◽  
Francis A. Farraye ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Inflammatory Bowel
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