Diverse synthetic approaches towards C1′-branched acyclic nucleoside phosphonates

2021 ◽  
Author(s):  
Filip Kalčic ◽  
Martin Dracinsky ◽  
Zlatko Janeba
Keyword(s):  
Acyclic Nucleoside Phosphonates ◽  
Synthetic Routes ◽  
Acyclic Nucleoside ◽  
Synthetic Approaches ◽  
Significant Class

Acyclic nucleoside phosphonates (ANPs) represent a significant class of antiviral, anticancer, and antiprotozoal compounds. It is therefore highly desirable to have diverse synthetic routes leading towards these molecules. In the...

Recent Synthetic Approaches and Biological Evaluations of Amino Hexahydroquinolines and Their Spirocyclic Structures

2019 ◽  
Vol 19 (7) ◽  
pp. 875-915 ◽  
Author(s):  
Amr M. Abdelmoniem ◽  
Magda F. Mohamed ◽  
Doaa M. Abdelmoniem ◽  
Said A.S. Ghozlan ◽  
Ismail A. Abdelhamid
Keyword(s):  
Double Bond ◽  
Calcium Channel ◽  
Michael Addition ◽  
Antitubercular Agents ◽  
Sar Studies ◽  
Two Component ◽  
Synthetic Routes ◽  
Synthetic Approaches ◽  
Three Components

In this review, the recent synthetic approaches of amino hexahydroquinolines and their spirocyclic structures were highlighted. The synthetic routes include, two-components, three-components or fourcomponents reactions. The two-component [3+3] atom combination reaction represents the simplest method. It involves Michael addition of the electron rich β-carbon of β-enaminones to the activated double bond of cinnamonitriles followed by cyclization to yield hexahydroquinoline compounds. The bioactivity profiles and SAR studies of these compounds were also reviewed with emphasis to the utility of these substances as antimicrobial, anticancer and antitubercular agents, as well as calcium channel modulators.

Acyclic nucleoside phosphonates and human telomerase inhibition

2005 ◽  
Author(s):  
Miroslav Hájek ◽  
Naděžda Matulová ◽  
Ivan Votruba ◽  
Antonín Holý ◽  
Eva Tloušťová
Keyword(s):  
Telomerase Inhibition ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Human Telomerase

Tyrosine-based prodrugs of acyclic nucleoside phosphonates

2014 ◽  
Author(s):  
Tomáš Tichý ◽  
Karel Pomeisl ◽  
Marcela Krečmerová ◽  
Charles E. McKenna
Keyword(s):  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside

scholarly journals In-silico designing of acyclic nucleoside phosphonates and their anti-HIV potential

2012 ◽  
Vol 12 (Suppl 1) ◽  
pp. P3
Author(s):  
Dipti Yadav ◽  
Anuradha Singh ◽  
Madhu Yadav ◽  
Ramendra K Singh
Keyword(s):  
In Silico ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Anti Hiv

scholarly journals Synthesis of fluorinated acyclic nucleoside phosphonates with 5-azacytosine base moiety

Tetrahedron ◽  
2019 ◽  
Vol 75 (39) ◽  
pp. 130529 ◽  
Author(s):  
Karel Pomeisl ◽  
Marcela Krečmerová ◽  
Radek Pohl ◽  
Robert Snoeck ◽  
Graciela Andrei
Keyword(s):  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Base Moiety
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