Electrocatalysis as a Key Strategy for the Total Synthesis of Natural Products

Organic & Biomolecular Chemistry ◽

10.1039/d1ob02115j ◽

2022 ◽

Author(s):

Mintu Munda ◽

Sovan Niyogi ◽

Kundan Shaw ◽

Sourav Kundu ◽

Rhituparna Nandi ◽

...

Keyword(s):

Natural Products ◽

Total Synthesis ◽

Environmentally Benign ◽

Powerful Approach ◽

Highly Effective

Electrochemical strategy has been the powerful approach for the synthesis of valuable intermediates, in particular heterocyclic motifs. It has proven to be an environmentally benign, highly effective and versatile platform...

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Non-Enzymatic Desymmetrization Reactions in Aqueous Media

Symmetry ◽

10.3390/sym13040720 ◽

2021 ◽

Vol 13 (4) ◽

pp. 720

Author(s):

Satomi Niwayama

Keyword(s):

Natural Products ◽

Total Synthesis ◽

Functional Groups ◽

Organic Compounds ◽

Recent Progress ◽

Aqueous Media ◽

Building Blocks ◽

Organic Reactions ◽

Environmentally Benign ◽

Enzymatic Desymmetrization

Symmetric organic compounds are generally obtained inexpensively, and therefore they can be attractive building blocks for the total synthesis of various pharmaceuticals and natural products. The drawback is that discriminating the identical functional groups in the symmetric compounds is difficult. Water is the most environmentally benign and inexpensive solvent. However, successful organic reactions in water are rather limited due to the hydrophobicity of organic compounds in general. Therefore, desymmetrization reactions in aqueous media are expected to offer versatile strategies for the synthesis of a variety of significant organic compounds. This review focuses on the recent progress of desymmetrization reactions of symmetric organic compounds in aqueous media without utilizing enzymes.

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A Highly Effective Diels-Alder Approach tocis-Clerodane Natural Products: First Total Synthesis of Solidago Alcohol

Synthesis ◽

10.1055/s-2004-815916 ◽

2004 ◽

pp. 271-275 ◽

Cited By ~ 2

Author(s):

Hsing-Jang Liu ◽

Tai Wei Ly ◽

Jyh-Hsiung Liao ◽

Kak-Shan Shia

Keyword(s):

Natural Products ◽

Total Synthesis ◽

Diels Alder ◽

Highly Effective

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A Highly Effective Diels—Alder Approach to cis-Clerodane Natural Products: First Total Synthesis of Solidago Alcohol (I).

ChemInform ◽

10.1002/chin.200426162 ◽

2004 ◽

Vol 35 (26) ◽

Author(s):

Tai Wei Ly ◽

Jyh-Hsiung Liao ◽

Kak-Shan Shia ◽

Hsing-Jang Liu

Keyword(s):

Natural Products ◽

Total Synthesis ◽

Diels Alder ◽

Highly Effective

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Total synthesis of pyranonaphthoquinone natural products

10.31274/rtd-180813-12358 ◽

1994 ◽

Author(s):

Jun Li

Keyword(s):

Natural Products ◽

Total Synthesis

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Application of Dess-Martin oxidation in total synthesis of natural products

Current Organic Synthesis ◽

10.2174/1570179417666200917102634 ◽

2020 ◽

Vol 17 ◽

Author(s):

Majid M. Heravi ◽

Tayebe Momeni ◽

Vahideh Zadsirjan ◽

Leila Mohammadi

Keyword(s):

Natural Products ◽

Total Synthesis ◽

Selective Oxidation ◽

Secondary Alcohols ◽

Aldehydes And Ketones

: Dess–Martin periodinane (DMP), is a commercially available chemical, frequently being utilized as a mild oxidative agent for the selective oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones, respectively. DMP shows several merits over other common oxidative agent such as chromium- and DMSO-based oxidants, thus it is habitually employed in the total synthesis of natural products. In this review, we try to underscore the applications of DMP as an effective oxidant in an appropriate step (steps) in the multistep total synthesis of natural products.

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