Synthetic strategy and structure–activity relationship (SAR) studies of 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1, Lificiguat): a review

RSC Advances ◽

10.1039/d1ra08120a ◽

2022 ◽

Vol 12 (1) ◽

pp. 251-264

Author(s):

Ko-Hua Yu ◽

Hsin-Yi Hung

Keyword(s):

Guanylate Cyclase ◽

Soluble Guanylate Cyclase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Synthetic Strategy ◽

Sar Studies ◽

Structure Activity ◽

Strategy And Structure ◽

Since 1994, YC-1 (Lificiguat) has been synthesized, and many targets for special bioactivities have been explored, such as stimulation of platelet-soluble guanylate cyclase, indirect elevation of platelet cGMP levels, and inhibition of HIF-1 and NF-κB.

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Structure Activity Relationship of Arylidene Pyrrolo and Pyrido [2,1-b] Quinazolones as Cytotoxic Agents: Synthesis, SAR Studies, Biological Evaluation and Docking Studies

Medicinal Chemistry ◽

10.2174/1573406411309050003 ◽

2013 ◽

Vol 9 (5) ◽

pp. 642-650 ◽

Author(s):

Veenu Mangla ◽

Kunal Nepali ◽

Gagandip Singh ◽

Jagjeet Singh ◽

Santosh Guru ◽

...

Keyword(s):

Structure Activity Relationship ◽

Docking Studies ◽

Biological Evaluation ◽

Cytotoxic Agents ◽

Activity Relationship ◽

Sar Studies ◽

Structure Activity ◽

Relationship Of

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Design, synthesis and structure–activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.10.037 ◽

2015 ◽

Vol 89 ◽

pp. 21-31 ◽

Author(s):

Ayyiliath M. Sajith ◽

K.K. Abdul Khader ◽

Nithin Joshi ◽

Manchala Nageswar Reddy ◽

M. Syed Ali Padusha ◽

...

Keyword(s):

Structure Activity Relationship ◽

Cytotoxic Agents ◽

Activity Relationship ◽

Design Synthesis ◽

Sar Studies ◽

Structure Activity

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Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.01.046 ◽

2016 ◽

Vol 111 ◽

pp. 138-159 ◽

Author(s):

Andrea Nuzzi ◽

Annalisa Fiasella ◽

Jose Antonio Ortega ◽

Chiara Pagliuca ◽

Stefano Ponzano ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Carbamic Acid ◽

Sar Studies ◽

Structure Activity

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Structure–activity relationship of novel low-generation dendrimers for gene delivery

Organic & Biomolecular Chemistry ◽

10.1039/c8ob01767k ◽

2018 ◽

Vol 16 (42) ◽

pp. 7833-7842 ◽

Author(s):

Yong-Guang Gao ◽

Xiao Lin ◽

Kai Dang ◽

Shan-Feng Jiang ◽

Ye Tian ◽

...

Keyword(s):

Gene Delivery ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Sar Studies ◽

Structure Activity ◽

Gene Vectors ◽

Relationship Of

Structure–activity relationship (SAR) studies are very critical to design ideal gene vectors for gene delivery.

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Design, synthesis and structure–activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: Dual activity as cholinesterase and Aβ-aggregation inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.02.030 ◽

2011 ◽

Vol 19 (7) ◽

pp. 2269-2281 ◽

Author(s):

Tarek Mohamed ◽

Xiaobei Zhao ◽

Lila K. Habib ◽

Jerry Yang ◽

Praveen P.N. Rao

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Sar Studies ◽

Structure Activity ◽

Aβ Aggregation ◽

Aggregation Inhibitors

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Synthesis and Structure–Activity Relationship (SAR) Studies of Novel Pyrazolopyridine Derivatives as Inhibitors of Enterovirus Replication

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b01863 ◽

2018 ◽

Vol 61 (4) ◽

pp. 1688-1703 ◽

Author(s):

Yanpeng Xing ◽

Jun Zuo ◽

Paul Krogstad ◽

Michael E. Jung

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Sar Studies ◽

Structure Activity

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Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112886 ◽

2021 ◽

Vol 209 ◽

pp. 112886

Author(s):

Santosh Kumar Verma ◽

Rameshwari Verma ◽

Shekhar Verma ◽

Yogesh Vaishnav ◽

S.P. Tiwari ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Sar Studies ◽

Structure Activity ◽

Oxadiazole Derivatives ◽

Tuberculosis Activity

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Stimulation of Orobanche ramosa seed germination by fusicoccin derivatives: A structure–activity relationship study

Phytochemistry ◽

10.1016/j.phytochem.2005.10.010 ◽

2006 ◽

Vol 67 (1) ◽

pp. 19-26 ◽

Author(s):

Antonio Evidente ◽

Anna Andolfi ◽

Michele Fiore ◽

Angela Boari ◽

Maurizio Vurro

Keyword(s):

Seed Germination ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Orobanche Ramosa ◽

Relationship Study ◽

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Structure-Activity Relationship (SAR) Studies on Oxazolidinone Antibacterial Agents. 2. Relationship between Lipophilicity and Antibacterial Activity in 5-Thiocarbonyl Oxazolidinones.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.49.353 ◽

2001 ◽

Vol 49 (4) ◽

pp. 353-360 ◽

Author(s):

Ryukou TOKUYAMA ◽

Yoshiei TAKAHASHI ◽

Yayoi TOMITA ◽

Masatoshi TSUBOUCHI ◽

Toshihiko YOSHIDA ◽

...

Keyword(s):

Antibacterial Activity ◽

Antibacterial Agents ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Sar Studies ◽

Structure Activity

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Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure–Activity Relationship (SAR) Studies

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b01188 ◽

2015 ◽

Vol 58 (23) ◽

pp. 9258-9272 ◽

Author(s):

Anders Bach ◽

Daniela Pizzirani ◽

Natalia Realini ◽

Valentina Vozella ◽

Debora Russo ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Acid Ceramidase ◽

Sar Studies ◽

Structure Activity

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