Therapy and regeneration-combined bone cements for minimally invasive treatment of neoplastic bone defects

2021 ◽  
Author(s):  
Yu Qu ◽  
Hui Zhuang ◽  
Meng Zhang ◽  
Yufeng Wang ◽  
Dong Zhai ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Minimally Invasive ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Tumor Resection ◽  
Bone Defects ◽  
Bone Cements ◽  
Invasive Treatment ◽  
Calcium Phosphate Cements ◽  
Bone Tumor Resection

Although calcium phosphate cements (CPC) have been clinically used to repair bone defects caused by bone tumor resection, traditional CPC cannot kill the remaining tumor cells after surgery and prevent...

scholarly journals A review of calcium phosphate cements and acrylic bone cements as injectable materials for bone repair and implant fixation

2019 ◽  
Vol 17 (4) ◽  
pp. 228080001987259 ◽  
Author(s):  
Azizeh-Mitra Yousefi
Keyword(s):  
Calcium Phosphate ◽  
Minimally Invasive ◽  
Bone Repair ◽  
Unmet Need ◽  
Balloon Kyphoplasty ◽  
Healthcare Systems ◽  
Bone Cements ◽  
Implant Fixation ◽  
Calcium Phosphate Cements ◽  
Autologous Bone Grafts

Treatment of bone defects caused by trauma or disease is a major burden on human healthcare systems. Although autologous bone grafts are considered as the gold standard, they are limited in availability and are associated with post-operative complications. Minimally invasive alternatives using injectable bone cements are currently used in certain clinical procedures, such as vertebroplasty and balloon kyphoplasty. Nevertheless, given the high incidence of fractures and pathologies that result in bone voids, there is an unmet need for injectable materials with desired properties for minimally invasive procedures. This paper provides an overview of the most common injectable bone cement materials for clinical use. The emphasis has been placed on calcium phosphate cements and acrylic bone cements, while enabling the readers to compare the opportunities and challenges for these two classes of bone cements. This paper also briefly reviews antibiotic-loaded bone cements used in bone repair and implant fixation, including their efficacy and cost for healthcare systems. A summary of the current challenges and recommendations for future directions has been brought in the concluding section of this paper.

scholarly journals The Accuracy of Three-Dimensional Planned Bone Tumor Resection Using Patient-Specific Instrument

2020 ◽  
Vol Volume 12 ◽  
pp. 6533-6540
Author(s):  
Daniel A Müller ◽  
Yannik Stutz ◽  
Lazaros Vlachopoulos ◽  
Mazda Farshad ◽  
Philipp Fürnstahl
Keyword(s):  
Bone Tumor ◽  
Tumor Resection ◽  
Three Dimensional ◽  
Patient Specific ◽  
Specific Instrument ◽  
Bone Tumor Resection

scholarly journals Epiphyseal Sparing and Reconstruction by Frozen Bone Autograft after Malignant Bone Tumor Resection in Children

Sarcoma ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Ahmed Hamed Kassem Abdelaal ◽  
Norio Yamamoto ◽  
Katsuhiro Hayashi ◽  
Akihiko Takeuchi ◽  
Shinji Miwa ◽  
...  
Keyword(s):  
Functional Outcome ◽  
Limb Salvage ◽  
Bone Tumor ◽  
Treatment Options ◽  
Tumor Resection ◽  
Limb Salvage Surgery ◽  
Leg Length ◽  
Primary Bone Tumors ◽  
Bone Tumor Resection ◽  
Bone Autograft

Limb salvage surgery has become the standard treatment for malignant primary bone tumors in the extremities. Limb salvage represents a challenge in skeletally immature patients. Several treatment options are available for limb reconstruction after tumor resection in children. We report our results using the technique of epiphyseal sparing and reconstruction with frozen autograft bone in 18 children. The mean follow-up period for the all patients included in this study is 72 ± 26 m. Eight patients remained disease-free, seven patients lived with no evidence of disease, two were alive but with disease, and one patient died of the disease. Five- and ten-year rates of survival were 94.4%. Graft survival at 5 and 10 years was 94.4%. Functional outcome using the Enneking scale was excellent in 17 patients (94.4%) and poor in one patient (5.5%). Complications include 2 nonunions, 2 fractures, 2 deep infections, 1 soft tissue recurrence, and leg length discrepancy in 7 cases. This technique is a good reconstructive choice in a child with a nonosteolytic primary or secondary bone tumor, responsive to chemotherapy, without involvement of the articular cartilage. It is a straight forward, effective, and biological technique, which affords immediate mobilization of joints and possible cryoimmune effects, with excellent long term functional outcome and less complication.

Intercalary Segmental Reconstruction of Long Bones After Malignant Bone Tumor Resection Using Primary Methyl Methacrylate Cement Spacer Interposition and Secondary Bone Grafting

2011 ◽  
Vol 31 (5) ◽  
pp. 570-576 ◽  
Author(s):  
Thierry Villemagne ◽  
Christian Bonnard ◽  
Franck Accadbled ◽  
Mohamed LʼKaissi ◽  
Benoit de Billy ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Bone Tumor ◽  
Bone Grafting ◽  
Tumor Resection ◽  
Cement Spacer ◽  
Long Bones ◽  
Malignant Bone Tumor ◽  
Bone Tumor Resection

Arthrodeses After Malignant Bone Tumor Resection in Children

Limb Salvage ◽  
1991 ◽  
pp. 543-551
Author(s):  
R. Capanna ◽  
M. Manfrini ◽  
D. Donati ◽  
A. Ferruzzi ◽  
M. Campanacci
Keyword(s):  
Bone Tumor ◽  
Tumor Resection ◽  
Malignant Bone Tumor ◽  
Bone Tumor Resection

SURVIVAL OF TOTAL KNEE REPLACEMENT WITH A MEGAPROSTHESIS AFTER BONE TUMOR RESECTION

2006 ◽  
Vol 88 (6) ◽  
pp. 1285-1293 ◽  
Author(s):  
DAVID BIAU ◽  
FLORENT FAURE ◽  
SANDRINE KATSAHIAN ◽  
CÉCILE JEANROT ◽  
BERNARD TOMENO ◽  
...  
Keyword(s):  
Total Knee Replacement ◽  
Knee Replacement ◽  
Bone Tumor ◽  
Tumor Resection ◽  
Total Knee ◽  
Bone Tumor Resection

Dimensional and thermal behaviour of calcium phosphate cements during setting compared to PMMA bone cements

1995 ◽  
Vol 14 (1) ◽  
pp. 4-5 ◽  
Author(s):  
E. FernÁndez ◽  
M. P. Ginebra ◽  
O. Bermúdez ◽  
M. G. Boltong ◽  
F. C. M. Driessens ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Thermal Behaviour ◽  
Bone Cements ◽  
Calcium Phosphate Cements
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