Synthetic peptides comprising sequences of the human immunoglobulin E heavy chain capable of releasing histamine
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A Site
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On the basis of previous studies on the structure-activity relationship of model polypeptide histamine liberators, a site within the Fc region of immunoglobulin E antibody molecules has been proposed as that responsible for the direct triggering of target mast cells after antigen challenge. Peptides comprising this region of the epsilon-chain have now been synthesized and shown to induce histamine release from normal rat peritoneal mast cells in a selective manner essentially similar to that mediated by anaphylactic antibody-antigen interaction.
2014 ◽
Vol 39
(1)
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pp. 83-90
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2009 ◽
Vol 25
(3)
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pp. 281-289
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1997 ◽
Vol 25
(02)
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pp. 163-167
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2001 ◽
Vol 107
(6)
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pp. 993-1000
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1967 ◽
Vol 71
(4)
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pp. 270-282
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