Non-selective cation channels in basolateral-membrane vesicles from pars recta of rabbit kidney proximal tubule
Keyword(s):
The characteristics of 86Rb+ fluxes through conductive channels in basolateral-membrane vesicles isolated from pars recta of rabbit kidney proximal tubule were investigated. In RbCl-, KCl- and NaCl-loaded vesicles a transient and almost equal accumulation of 86Rb+ was observed. The uptakes of 86Rb+ were inhibited to the same extent by 10 mM-BaCl2 in all loadings. The accumulation was driven by an electrical diffusion potential. The 86Rb+ flux was dependent on intravesicular Ca2+. Increasing concentrations of Ca2+ gradually decreased the 86Rb+ uptake. At 10 microM-Ca2+ the radioisotope flux was below 20% of control. The vesicles containing the channel showed very low selectivity among the univalent cations K+, Rb+, Li+, Na+ and choline+.
1985 ◽
Vol 249
(6)
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pp. F789-F798
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1988 ◽
Vol 254
(5)
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pp. F711-F718
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1987 ◽
Vol 16
(3)
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pp. 213-225
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1989 ◽
Vol 986
(2)
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pp. 332-340
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Electrogenic uptake of d-imino acids by luminal membrane vesicles from rabbit kidney proximal tubule
1989 ◽
Vol 984
(2)
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pp. 231-237
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Keyword(s):
1984 ◽
Vol 354
(1)
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pp. 55-67
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Keyword(s):
1986 ◽
Vol 856
(3)
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pp. 471-481
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1983 ◽
Vol 244
(6)
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pp. F686-F695
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