Regulation of oxidative degradation of l-lysine in rat liver mitochondria
Keyword(s):
The generation of 14CO2 from [1-14C]lysine by hepatic mitochondria through the saccharopine pathway is controlled by intramitochondrial concentrations of lysine, 2-oxoglutarate and NADPH. Mitochondria, isolated from rats pre-treated with glucagon, exhibited higher activities of L-lysine: 2-oxoglutarate reductase, saccharopine dehydrogenase and 2-aminoadipate aminotransferase. The flux through this pathway is stimulated in liver mitochondria after glucagon treatment. Multiple regulation of lysine oxidation in liver mitochondria confirms a complex mechanism of ‘mitochondrial activation’ by glucagon.
1971 ◽
Vol 29
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pp. 570-571
2016 ◽
Vol 7
(4)
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pp. 349-361
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1988 ◽
Vol 189
(1)
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pp. 39-44
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1961 ◽
Vol 236
(1)
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pp. 221-224
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1985 ◽
Vol 260
(2)
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pp. 1311-1325
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1971 ◽
Vol 246
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pp. 7139-7143
1968 ◽
Vol 243
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pp. 3000-3008
1978 ◽
Vol 253
(8)
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pp. 2716-2723
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1976 ◽
Vol 251
(17)
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pp. 5251-5258
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1975 ◽
Vol 250
(22)
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pp. 8856-8862