Changes in citric acid cycle enzymes in ageing tomato fruit mitochondria

1987 ◽  
Vol 15 (5) ◽  
pp. 840-841
Author(s):  
DAVID JEFFERY ◽  
P. DAVID ◽  
J. WEITZMAN ◽  
PETER W. GOODENOUGH
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Tomato Fruit ◽  
Acid Cycle ◽  
Citric Acid Cycle Enzymes

Regulatory Consequences of Organization of Citric Acid Cycle Enzymes

1992 ◽  
pp. 249-260 ◽  
Author(s):  
B. SUMEGI ◽  
A.D. SHERRY ◽  
Z. PORPACZY ◽  
M.T. MCCAMMON ◽  
C.R. MALLOY ◽  
...  
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Acid Cycle ◽  
Citric Acid Cycle Enzymes

scholarly journals The activities of the citric acid-cycle enzymes in rat bone-marrow cells

1968 ◽  
Vol 108 (3) ◽  
pp. 413-415
Author(s):  
Eugene Goldwasser
Keyword(s):  
Bone Marrow ◽  
Citric Acid ◽  
Citric Acid Cycle ◽  
Citrate Synthase ◽  
Bone Marrow Cells ◽  
Mitochondrial Enzymes ◽  
Acid Cycle ◽  
Citric Acid Cycle Enzymes ◽  
Rat Bone ◽  
Marrow Cells

The activities of the eight citric acid-cycle enzymes of rat bone-marrow cells were determined along with several other mitochondrial and non-mitochondrial enzymes. Four of the citric acid-cycle enzymes (aconitase, succinyl-CoA thiokinase, α-oxoglutarate dehydrogenase and succinate dehydrogenase) have closely similar low activities; two [isocitrate dehydrogenase (NAD) and citrate synthase] have intermediate activities; the remaining two (malate dehydrogenase and fumarase) have high activities. The other enzymes surveyed also exhibited a spread of three orders of magnitude, the mitochondrial enzymes showing no less variation than the others.

The extraordinary mitochondrion and unusual citric acid cycle in Trypanosoma brucei

2005 ◽  
Vol 33 (5) ◽  
pp. 967-971 ◽  
Author(s):  
J.J. van Hellemond ◽  
F.R. Opperdoes ◽  
A.G.M. Tielens
Keyword(s):  
Citric Acid ◽  
Energy Metabolism ◽  
Trypanosoma Brucei ◽  
Citric Acid Cycle ◽  
Clinical Importance ◽  
African Trypanosomes ◽  
Acid Cycle ◽  
Fermentative Metabolism ◽  
Influence Of Substrate ◽  
Citric Acid Cycle Enzymes

African trypanosomes are parasitic protozoa that cause sleeping sickness and nagana. Trypanosomes are not only of scientific interest because of their clinical importance, but also because these protozoa contain several very unusual biological features, such as their specially adapted mitochondrion and the compartmentalization of glycolytic enzymes in glycosomes. The energy metabolism of Trypanosoma brucei differs significantly from that of their hosts and changes drastically during the life cycle. Despite the presence of all citric acid cycle enzymes in procyclic insect-stage T. brucei, citric acid cycle activity is not used for energy generation. Recent investigations on the influence of substrate availability on the type of energy metabolism showed that absence of glycolytic substrates did not induce a shift from a fermentative metabolism to complete oxidation of substrates. Apparently, insect-stage T. brucei use parts of the citric acid cycle for other purposes than for complete degradation of mitochondrial substrates. Parts of the cycle are suggested to be used for (i) transport of acetyl-CoA units from the mitochondrion to the cytosol for the biosynthesis of fatty acids, (ii) degradation of proline and glutamate to succinate, (iii) generation of malate, which can then be used for gluconeogenesis. Therefore the citric acid cycle in trypanosomes does not function as a cycle.

scholarly journals Induction of citric acid cycle enzymes during initiation of sporulation by guanine nucleotide deprivation.

1981 ◽  
Vol 146 (1) ◽  
pp. 337-344 ◽  
Author(s):  
B Uratani-Wong ◽  
J M Lopez ◽  
E Freese
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Guanine Nucleotide ◽  
Acid Cycle ◽  
Citric Acid Cycle Enzymes

Organization of citric acid cycle enzymes into a multienzyme cluster

FEBS Letters ◽  
1986 ◽  
Vol 201 (2) ◽  
pp. 267-270 ◽  
Author(s):  
Sarah J. Barnes ◽  
P.D.J. Weitzman
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Acid Cycle ◽  
Citric Acid Cycle Enzymes

scholarly journals Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements.

1996 ◽  
Vol 93 (10) ◽  
pp. 4925-4930 ◽  
Author(s):  
N. K. Gray ◽  
K. Pantopoulos ◽  
T. Dandekar ◽  
B. A. Ackrell ◽  
M. W. Hentze
Keyword(s):  
Citric Acid ◽  
Translational Regulation ◽  
Citric Acid Cycle ◽  
Acid Cycle ◽  
Citric Acid Cycle Enzymes ◽  
Iron Responsive Elements
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