Studies with wortmannin indicate that insulin stimulation of lipogenesis involves multiple signalling pathways

1995 ◽  
Vol 23 (2) ◽  
pp. 206S-206S ◽  
Author(s):  
S. KELLY MOULE ◽  
NIGEL J. EDGELL ◽  
GAVIN I. WELSH ◽  
TRICIA A. DIGGLE ◽  
CHRISTOPHER G. PROUD ◽  
...  
Keyword(s):  
Signalling Pathways ◽  
Insulin Stimulation ◽  
Stimulation Of

scholarly journals Insulin stimulation of pyruvate dehydrogenase in adipocytes involves two distinct signalling pathways

2003 ◽  
Vol 369 (2) ◽  
pp. 351-356 ◽  
Author(s):  
Sam A. JOHNSON ◽  
Richard M. DENTON
Keyword(s):  
Pyruvate Dehydrogenase ◽  
Mitogen Activated Protein Kinase ◽  
Signalling Pathways ◽  
Maximal Effect ◽  
Insulin Stimulation ◽  
Rat Adipocytes ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Phosphoinositide 3 Kinase ◽  
Stimulation Of

In isolated rat adipocytes, the insulin stimulation of pyruvate dehydrogenase can be partially inhibited by inhibitors of PI3K (phosphoinositide 3-kinase) and MEK1/2 (mitogen-activated protein kinase/extracellular signal-regulated kinase kinase). In combination, U0126 and wortmannin completely block the insulin stimulation of pyruvate dehydrogenase. It is concluded that the effect of insulin on pyruvate dehydrogenase in rat adipocytes involves two distinct signalling pathways: one is sensitive to wortmannin and the other to U0126. The synthetic phosphoinositolglycan PIG41 can activate pyruvate dehydrogenase but the activation is only approx. 30% of the maximal effect of insulin. This modest activation can be completely blocked by wortmannin alone, suggesting that PIG41 acts through only one of the pathways leading to the activation of pyruvate dehydrogenase.

scholarly journals Insulin Stimulation of Amino Acid Uptake in Rat Diaphragm

1968 ◽  
Vol 243 (8) ◽  
pp. 1846-1853 ◽  
Author(s):  
L J Elsas ◽  
I Albrecht ◽  
L E Rosenberg
Keyword(s):  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Rat Diaphragm ◽  
Insulin Stimulation ◽  
Stimulation Of

Insulin stimulation of glucose transport in adipose cells. An energy-dependent process

Biochemistry ◽  
1977 ◽  
Vol 16 (6) ◽  
pp. 1151-1158 ◽  
Author(s):  
Visvanathan Chandramouli ◽  
Marianne Milligan ◽  
James R. Carter
Keyword(s):  
Glucose Transport ◽  
Insulin Stimulation ◽  
Dependent Process ◽  
Energy Dependent ◽  
Adipose Cells ◽  
Stimulation Of

scholarly journals Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes.

1993 ◽  
Vol 268 (7) ◽  
pp. 5272-5278 ◽  
Author(s):  
G. Inoue ◽  
H. Kuzuya ◽  
T. Hayashi ◽  
M. Okamoto ◽  
Y. Yoshimasa ◽  
...  
Keyword(s):  
Glucose Transport ◽  
Insulin Stimulation ◽  
Stimulation Of

scholarly journals Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

2012 ◽  
Vol 109 (40) ◽  
pp. 16184-16189 ◽  
Author(s):  
J. L. Owen ◽  
Y. Zhang ◽  
S.-H. Bae ◽  
M. S. Farooqi ◽  
G. Liang ◽  
...  
Keyword(s):  
Rat Hepatocytes ◽  
Transgenic Rat ◽  
Insulin Stimulation ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Stimulation Of

scholarly journals INSULIN STIMULATION OF GROWTH HORMONE RELEASE. 574

1996 ◽  
Vol 39 ◽  
pp. 98-98 ◽  
Author(s):  
Janine E Sanchez ◽  
Jose Perez-Rodriguez ◽  
William W Cleveland
Keyword(s):  
Growth Hormone ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Insulin Stimulation ◽  
Stimulation Of
Sign in / Sign up

Export Citation Format

Share Document