Amyloid-β oligomers: their production, toxicity and therapeutic inhibition
2002 ◽
Vol 30
(4)
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pp. 552-557
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Keyword(s):
Despite extensive genetic and animal modelling data that support a central role for the amyloid β-protein (Aβ) in the genesis of Alzheimer's disease, the specific form(s) of Aβ which causes injury to neurons in vivo has not been identified. In the present study, we examine the importance of soluble, pre-fibrillar assemblies of Aβ as mediators of neurotoxicity. Specifically, we review the role of cell-derived SDS-stable oligomers, their blocking of hippocampal long-term potentiation in vivo and the finding that this blocking can be prevented by prior treatment of oligomer-producing cells withγ-secretase inhibitors.
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2009 ◽
Vol 450
(3)
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pp. 306-310
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2008 ◽
Vol 77
(2-3)
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pp. 84-90
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2008 ◽
Vol 283
(24)
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pp. 16790-16800
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2007 ◽
Vol 26
(5)
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pp. 1289-1298
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