RDL receptors

2009 ◽  
Vol 37 (6) ◽  
pp. 1404-1406 ◽  
Author(s):  
Ian McGonigle ◽  
Sarah C.R. Lummis
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ion Channels ◽  
Gabaa Receptors ◽  
Target Site ◽  
Aminobutyric Acid ◽  
Nicotinic Acetylcholine ◽  
Inhibitory Neurotransmission ◽  
Insect Cns ◽  
Gated Ion Channels

RDL receptors are invertebrate members of the Cys-loop family of ligand-gated ion channels. They are GABA (γ-aminobutyric acid)-activated chloride-selective receptors that are closely related to their vertebrate orthologues, the GABAA receptors, as well as other Cys-loop receptors such as the ionotropic glycine, nicotinic acetylcholine and 5-HT3 receptors. RDL receptors are widely expressed throughout the insect CNS (central nervous system) and are important in inhibitory neurotransmission. They are therefore a major insecticidal target site.

Distribution of the P2X2 receptor subunit of the ATP-gated ion channels in the rat central nervous system

1999 ◽  
Vol 407 (1) ◽  
pp. 11-32 ◽  
Author(s):  
Refik Kanjhan ◽  
Gary D. Housley ◽  
Lucille D. Burton ◽  
David L. Christie ◽  
Andree Kippenberger ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ion Channels ◽  
Receptor Subunit ◽  
P2x2 Receptor ◽  
Gated Ion Channels

Distribution of gamma-aminobutyric acid (GABA) in the central nervous system of the male mud crab, Scylla olivacea

Crustaceana ◽  
2020 ◽  
Vol 93 (9-10) ◽  
pp. 1123-1134
Author(s):  
Kanjana Khornchatri ◽  
Jirawat Saetan ◽  
Sirirak Mukem ◽  
Prasert Sobhon ◽  
Tipsuda Thongbuakaew
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Distribution Pattern ◽  
Nerve Cord ◽  
Ventral Nerve Cord ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Mud Crab ◽  
Decapod Crustaceans ◽  
The Central Nervous System

Abstract Gamma-aminobutyric acid (GABA) is a neurotransmitter that is widely spread in vertebrate and invertebrate nervous systems and modulates essential physiological roles. Previous studies have reported the distribution of several neurotransmitters throughout the central nervous system (CNS) of decapod crustaceans. However, the existence and distribution of GABA in the mud crab’s, Scylla olivacea, CNS has still not been reported. In this study, we investigated the distribution of GABA using immunohistochemistry. The result revealed that GABA immunoreactivity (-ir) was observed in neurons and fibres throughout the CNS, including the eyestalk, brain, and ventral nerve cord of S. olivacea. Therefore, the existence and extensive distribution pattern of GABA in the CNS of the male mud crab suggest its possible roles in feeding, locomotion, and also reproduction.

Extrasynaptic receptors on cell bodies of neurons in central nervous system of the leech

1977 ◽  
Vol 40 (2) ◽  
pp. 446-452 ◽  
Author(s):  
P. B. Sargent ◽  
K. W. Yau ◽  
J. G. Nicholls
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Glutamic Acid ◽  
Systematic Study ◽  
Receptive Fields ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Light Touch ◽  
Nociceptive Neurons ◽  
Extrasynaptic Receptors

1. A systematic study has been made of the sensitivity of identified sensory and motoneurons in the leech central nervous system to chemical transmitter substances. 2. The following substances elicited responses from the cell bodies of individual neurons: acetylcholine, 5-hydroxytryptamine, gamma-aminobutyric acid, glutamic acid, glycine, dopamine, and norepinephrine. Since the cell bodies of leech neurons are free of synapses, the receptors that give rise to these responses are extrasynaptic. 3. Sensory and motoneurons of different function had characteristic complements of extrasynaptic receptors. For example, mechanosensory cells responding to light touch, to pressure, and to noxious stimuli could be distinguished by their responses to iontophoretically applied compounds. For one of these modalities (nociceptive), neurons with different receptive fields but otherwise similar properties had markedly distinct extrasynaptic receptors. The possible significance of extrasynaptic receptors is discussed.

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