The Contrasting Effects on Bone Histology of Vitamin D and of Calcium Carbonate in the Osteomalacia of Chronic Renal Failure

1974 ◽  
Vol 47 (1) ◽  
pp. 23-42 ◽  
Author(s):  
J. B. Eastwood ◽  
P. J. Bordier ◽  
E. M. Clarkson ◽  
S. Tun Chot ◽  
H. E. De Wardener
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Direct Action ◽  
Plasma Calcium ◽  
Marked Rise ◽  
Osteoid Tissue ◽  
Punctate Calcification ◽  
Calcium Compounds ◽  
Plasma Phosphorus

1. The histological appearances of cancellous bone from the ilium have been quantified in thirteen patients with osteomalacia due to chronic renal failure. 2. There was an excess of osteoid tissue and a reduction in the extent of the calcification front in that osteoid lamella lying next to calcified bone. 3. Administration of calcium compounds orally produced an increase of punctate calcification within the osteoid, but there was no change in the extent of the calcification front. 4. Administration of vitamin D produced a marked rise in the extent of the calcification front but no increase of punctate calcification within the osteoid. 5. This rise in the extent of the calcification front was not dependent on a rise in plasma calcium × plasma phosphorus product. 6. It is concluded that vitamin D has a direct action on the bone in patients with the osteomalacia of chronic renal failure.

The Effect of Aluminium Hydroxide on Calcium, Phosphorus and Aluminium Balances, the Serum Parathyroid Hormone Concentration and the Aluminium Content of Bone in Patients with Chronic Renal Failure

1972 ◽  
Vol 43 (4) ◽  
pp. 519-531 ◽  
Author(s):  
E. M. Clarkson ◽  
V. A. Luck ◽  
W. V. Hynson ◽  
R. R. Bailey ◽  
J. B. Eastwood ◽  
...  
Keyword(s):  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
Aluminium Hydroxide ◽  
Plasma Calcium ◽  
Aluminium Content ◽  
Serum Parathyroid Hormone ◽  
Calcium Phosphorus ◽  
Aluminium Hydroxide Gel ◽  
Plasma Phosphorus

1. Eight patients with chronic renal failure (creatinine clearance 4·9–22·0 ml/min) were given 75–150 ml of aluminium hydroxide gel (‘Aludrox’) daily for 20–32 days. 2. In all patients there was a decrease in plasma phosphorus. The phosphorus balance became more negative in four and less positive in one, remained unchanged in two, and became positive in one. 3. Patients absorbed 100–568 mg of aluminium daily. In two of three patients the content of aluminium in the iliac bone increased but not above normal values. 4. The concentration of parathyroid hormone was decreased by aluminium hydroxide therapy in three patients in whom there was an increase in plasma calcium and in one other patient in whom plasma calcium did not change.

scholarly journals PREVALENCE OF VITAMIN D DEFICIENCY IN DIFFERENT GROUPS OF CHRONIC RENAL FAILURE PATIENTS

2015 ◽  
Vol 21 (3) ◽  
pp. 887-890 ◽  
Author(s):  
Bistra T. Galunska ◽  
◽  
Daniela I. Gerova ◽  
Dobrin N. Paskalev ◽  
Rositza Y. Zorcheva ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Vitamin D Deficiency

Vitamin D and its analogs in chronic renal failure

1997 ◽  
Vol 7 (S3) ◽  
pp. 202-208 ◽  
Author(s):  
E. Slatopolsky ◽  
A. J. Brown
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
Chronic Renal Failure

VITAMIN-D METABOLISM IN CHRONIC RENAL FAILURE

The Lancet ◽  
1975 ◽  
Vol 305 (7916) ◽  
pp. 1147
Author(s):  
C.E. Dent ◽  
Mercedes Domenech ◽  
J.M. Gertner
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Vitamin D Metabolism

Role of uremia, brain calcium, and parathyroid hormone on changes in electroencephalogram in chronic renal failure

1984 ◽  
Vol 246 (5) ◽  
pp. F575-F579
Author(s):  
M. Akmal ◽  
D. A. Goldstein ◽  
S. Multani ◽  
S. G. Massry
Keyword(s):  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
White Matter ◽  
Blood Levels ◽  
Marked Rise ◽  
Per Se ◽  
Serum Pth ◽  
Electroencephalogram Eeg

Acute uremia is associated with increased calcium (Ca) in brain and changes in electroencephalogram (EEG), and both derangements are related to excess parathyroid hormone (PTH). Also changes in EEG in patients with chronic renal failure (CRF) correlated directly with blood levels of PTH, and fall in PTH was followed by improvement in EEG. We examined whether chronic uremia per se has an effect on brain calcium or EEG. Uremia was produced by 5/6 nephrectomy and maintained for 32-70 wk in seven thyroparathyroidectomized (TPTX) and seven control dogs. There were no differences in creatinine clearance and serum electrolytes except for HCO3, which was lower in control animals (P less than 0.01). Serum PTH was undetectable in TPTX dogs but was significantly elevated in control animals (32.3 +/- 3.3 mu leq /ml). Calcium in gray and white matter was significantly increased in both groups but much higher in control animals. The percent waves of less than 7 Hz in EEG were similar in both groups prior to uremia (TPTX 4.6 +/- 0.8 vs. control 4.2 +/- 0.5%) but remained unchanged in TPTX animals and increased significantly in control dogs (19.0 +/- 1.3%) after uremia. These data suggest that CRF per se is associated with marked rise in Ca in both gray and white matter and increment is higher in the presence of PTH. Disturbance in EEG in a state of CRF requires the presence of excess PTH and is prevented despite increased Ca in brain if hyperparathyroidism is not allowed to develop.

Treatment of uremic bone disease action of 5,6-trans-25-hydroxycholecalciferol (a vitamin D-analog) in chronic renal failure

1973 ◽  
Vol 51 (19) ◽  
pp. 979-981 ◽  
Author(s):  
D. Herrath ◽  
K. Schaefer ◽  
D. Kraft ◽  
H. -G. Grigoleit ◽  
P. Koeppe
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Bone Disease ◽  
Vitamin D Analog ◽  
25 Hydroxycholecalciferol
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