The Effect of Aluminium Hydroxide on Calcium, Phosphorus and Aluminium Balances, the Serum Parathyroid Hormone Concentration and the Aluminium Content of Bone in Patients with Chronic Renal Failure

1972 ◽  
Vol 43 (4) ◽  
pp. 519-531 ◽  
Author(s):  
E. M. Clarkson ◽  
V. A. Luck ◽  
W. V. Hynson ◽  
R. R. Bailey ◽  
J. B. Eastwood ◽  
...  
Keyword(s):  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
Aluminium Hydroxide ◽  
Plasma Calcium ◽  
Aluminium Content ◽  
Serum Parathyroid Hormone ◽  
Calcium Phosphorus ◽  
Aluminium Hydroxide Gel ◽  
Plasma Phosphorus

1. Eight patients with chronic renal failure (creatinine clearance 4·9–22·0 ml/min) were given 75–150 ml of aluminium hydroxide gel (‘Aludrox’) daily for 20–32 days. 2. In all patients there was a decrease in plasma phosphorus. The phosphorus balance became more negative in four and less positive in one, remained unchanged in two, and became positive in one. 3. Patients absorbed 100–568 mg of aluminium daily. In two of three patients the content of aluminium in the iliac bone increased but not above normal values. 4. The concentration of parathyroid hormone was decreased by aluminium hydroxide therapy in three patients in whom there was an increase in plasma calcium and in one other patient in whom plasma calcium did not change.

The Effect of Aluminium Hydroxide Orally on Calcium, Phosphorus and Aluminium Metabolism in Normal Subjects

1976 ◽  
Vol 51 (4) ◽  
pp. 407-414 ◽  
Author(s):  
J. M. Cam ◽  
V. A. Luck ◽  
J. B. Eastwood ◽  
H. E. de Wardener
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Aluminium Hydroxide ◽  
Normal Subjects ◽  
The Other ◽  
Calcium Balance ◽  
Phosphorus Balance ◽  
Calcium Phosphorus ◽  
Aluminium Hydroxide Gel ◽  
Plasma Phosphorus

1. Five normal subjects were given 100 ml of aluminium hydroxide gel per day for 28 days. 2. The phosphorus balance became more positive in one subject, less negative in two and changed from negative to positive in the other two subjects. This was accompanied by a rise in the concentration of the fasting morning plasma phosphorus. Calcium balance did not change. 3. The normal subjects absorbed 0·3–3·6 mmol of aluminium/day, which is significantly less than that absorbed by five patients with chronic renal failure, three of whom were studied before, and two after, the observations on the normal subjects had been completed. 4. In a further five normal subjects on 100 ml of aluminium hydroxide gel/day the 08.00 hours concentration of plasma phosphorus did not fall, though there was a fall at 11.00, 14.00 and 17.00 hours.

The Effect of Aluminium Hydroxide on Calcium, Phosphorus and Aluminium Balances and the Plasma Parathyroid Hormone in Patients with Chronic Renal Failure

1971 ◽  
Vol 41 (2) ◽  
pp. 5P-6P ◽  
Author(s):  
R. R. Bailey ◽  
J. B. Eastwood ◽  
E. M. Clarkson ◽  
V. A. Luck ◽  
W. V. Hynson ◽  
...  
Keyword(s):  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
Aluminium Hydroxide ◽  
Calcium Phosphorus

Association between vitamin D receptor Fokl polymorphism and serum parathyroid hormone level in patients with chronic renal failure

2005 ◽  
Vol 28 (4) ◽  
pp. 117-121 ◽  
Author(s):  
E. Vigo Gago ◽  
C. Cadarso-Suárez ◽  
R. Perez-Fernandez ◽  
R. Romero Burgos ◽  
J. Devesa Mugica ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
Vitamin D Receptor ◽  
Hormone Level ◽  
Parathyroid Hormone Level ◽  
Serum Parathyroid Hormone

scholarly journals Effect of aluminium hydroxide on serum ionised calcium, immunoreactive parathyroid hormone, and aluminium in chronic renal failure.

BMJ ◽  
1982 ◽  
Vol 284 (6318) ◽  
pp. 776-778 ◽  
Author(s):  
C K Biswas ◽  
R S Arze ◽  
J M Ramos ◽  
M K Ward ◽  
J H Dewar ◽  
...  
Keyword(s):  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
Aluminium Hydroxide ◽  
Ionised Calcium ◽  
Immunoreactive Parathyroid Hormone

scholarly journals Study of prevalence of secondary hyperparathyroidism in chronic renal failure in hadoti region

2019 ◽  
Vol 7 (8) ◽  
pp. 2903
Author(s):  
Chiranjee Lal Dayma ◽  
Devendra Ajmera ◽  
Shiv Charan Jelia ◽  
Pankaj Jain
Keyword(s):  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
Secondary Hyperparathyroidism ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Hormone Level ◽  
Serum Parathyroid Hormone ◽  
The Difference

Background: Secondary hyperparathyroidism is known and early complication of chronic renal failure patients. Aim of this study was to assess the prevalence of secondary hyperparathyroidism and correlation between serum parathyroid hormone level with biochemical parameters in renal failure patients in tertiary care hospital in Kota, Rajasthan.Methods: A cross sectional observational study was carried out in 50 patients who had creatinine clearance of 30ml/min/1.73m2 or less for greater than 6 weeks attended the OPD of department of General Medicine, New Medical College hospital, Kota, Rajasthan from May 2018 to November 2018. Investigations like complete blood count, renal function test, urine routine microscopy and USG abdomen with serum parathyroid hormone, serum phosphorus, serum calcium levels were done. Serum parathyroid hormone level was done by calorimetric method.Results: The prevalence of secondary hyperparathyroidism in our study was 72%.In hyperparathyroidism patient’s serum calcium level was low and the difference was highly significant (p<0.001). There is negative correlation between S.PTH and S. calcium level (r=-0.536). Mean serum calcium level in our study is 1.6mmol/l. In hyperparathyroidism patient’s serum phosphate level was high and the difference was highly significant (p<0.001). There was positive correlation between S.PTH and S.PO4 level (r=0.402). Mean serum phosphorus level in our study is 5.7 mg/dl. Prevalence of hyperparathyroidism was high among CRF patients with normal BP than hypertensive patients and with normal sugar than diabetics but the difference in proportion was not significant (p=0.87, p=0.98 respectively). 90% patients were on haemodialysis while 10% patients were on conservative management.Conclusions: Early detection of secondary hyperparathyroidism in chronic renal failure patients can reduce its complications like bone fracture and cardiovascular complications.

The Contrasting Effects on Bone Histology of Vitamin D and of Calcium Carbonate in the Osteomalacia of Chronic Renal Failure

1974 ◽  
Vol 47 (1) ◽  
pp. 23-42 ◽  
Author(s):  
J. B. Eastwood ◽  
P. J. Bordier ◽  
E. M. Clarkson ◽  
S. Tun Chot ◽  
H. E. De Wardener
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Direct Action ◽  
Plasma Calcium ◽  
Marked Rise ◽  
Osteoid Tissue ◽  
Punctate Calcification ◽  
Calcium Compounds ◽  
Plasma Phosphorus

1. The histological appearances of cancellous bone from the ilium have been quantified in thirteen patients with osteomalacia due to chronic renal failure. 2. There was an excess of osteoid tissue and a reduction in the extent of the calcification front in that osteoid lamella lying next to calcified bone. 3. Administration of calcium compounds orally produced an increase of punctate calcification within the osteoid, but there was no change in the extent of the calcification front. 4. Administration of vitamin D produced a marked rise in the extent of the calcification front but no increase of punctate calcification within the osteoid. 5. This rise in the extent of the calcification front was not dependent on a rise in plasma calcium × plasma phosphorus product. 6. It is concluded that vitamin D has a direct action on the bone in patients with the osteomalacia of chronic renal failure.

Sign in / Sign up

Export Citation Format

Share Document