Serum Dopamine β-Hydroxylase Activity in Essential Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 465s-467s ◽  
Author(s):  
K. Aoki ◽  
K. Tazumi ◽  
T. Yoshida ◽  
S. Kato ◽  
I. Sato ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Enzyme Activity ◽  
Essential Hypertension ◽  
Hydroxylase Activity ◽  
Serum Enzyme ◽  
Serum Enzyme Activity ◽  
Control Subjects ◽  
Propranolol Administration ◽  
Normotensive Control

1. Serum dopamine β-hydroxylase activity was determined in normotensive control subjects and patients with labile or established essential hypertension. The enzyme activity was 25·9 ± 1·9 (sem), 29·6±2·5 and 25·1 ± 1·9 μmol min—1 1—1, for control, labile and established hypertensive subjects respectively. 2. Neither blood pressure nor serum dopamine β-hydroxylase activity was changed in normotensive control subjects by administration of phentolamine; however, in patients with essential hypertension blood pressure was significantly decreased (P < 0·01) and serum dopamine β-hydroxylase activity was slightly increased. With propranolol administration, blood pressure and the serum enzyme activity were not significantly changed in normotensive or hypertensive subjects. 3. Our results suggest that there is no correlation between serum dopamine β-hydroxylase activity and blood pressure.

Relation of Plasma Noradrenaline to Blood Pressure, Age, Sex and Sodium Balance in Patients with Stable Essential Hypertension and in Normotensive Subjects

1978 ◽  
Vol 55 (s4) ◽  
pp. 81s-83s ◽  
Author(s):  
H. M. Brecht ◽  
W. Schoeppe
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Essential Hypertension ◽  
Diastolic Blood Pressure ◽  
Plasma Noradrenaline ◽  
Sodium Balance ◽  
Creatinine Ratio ◽  
Control Subjects ◽  
Normotensive Subjects ◽  
Normotensive Control

1. Plasma noradrenaline was measured in 125 patients with stable essential hypertension (WHO I—II) and in 107 normotensive control subjects lying and standing. 2. In normotensive subjects and in patients with essential hypertension no sex-related differences of plasma noradrenaline were found between age-matched groups. 3. Plasma noradrenaline was not related to sodium balance indexed by urinary sodium/creatinine ratio. 4. In patients with essential hypertension plasma noradrenaline increases with age. 5. Mean plasma noradrenaline concentrations are significantly higher in patients with essential hypertension compared with age-matched normotensive subjects both lying and standing. 6. In patients with essential hypertension diastolic blood pressure and heart rate correlated significantly with supine plasma noradrenaline concentrations.

Effects of Blood Pressure Reduction on the Structural Vascular Abnormality in Skin and Muscle Vascular Beds in Human Essential Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 77s-79s ◽  
Author(s):  
R. Sivertsson ◽  
L. Hansson
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Vascular Resistance ◽  
Patient Group ◽  
Maximal Dilatation ◽  
Vascular Abnormality ◽  
Control Subjects ◽  
Vascular Beds ◽  
Hypertensive Therapy ◽  
Normotensive Control

1. Vascular resistance at maximal vasodilatation was examined in two vascular beds in two groups of hypertensive patients and in normotensive control subjects before and during anti-hypertensive therapy in the hypertension groups. 2. In one group of twelve untreated patients with essential hypertension, examined with plethysmography and intra-arterial blood pressure recording, a significantly higher vascular resistance at maximal vasodilatation was found in the hands compared with normotensive control subjects matched for age, sex, weight and height. This indicated a structural vascular abnormality in the patient group. 3. After 5 years of anti-hypertensive therapy in the patient group the difference in vascular resistance between patients and control subjects had decreased significantly, indicating a reversibility of the structural vascular abnormality. 4. Vascular resistance at maximal vasodilatation was examined in the calves of twelve untreated patients with essential hypertension and fourteen normotensive control subjects. Plethysmographic technique and indirect blood pressure recordings were used. A significantly higher vascular resistance was found in patients than in control subjects, indicating a structural vascular abnormality also in this vascular bed. 5. Anti-hypertensive treatment for 6 months in the patient group did not change vascular resistance at maximal dilatation, indicating that the structural vascular abnormality remained. 6. During acute reduction of blood pressure in hypertension by means of trimethaphan infusion, blood pressure and blood flow to the hands were reduced proportionally with no change of vascular resistance at maximal vasodilatation. 7. This indicates that resistance at maximal dilatation was unaffected by the acute reduction of blood pressure, in contrast to the findings after prolonged reduction of blood pressure in this vascular bed.

Does Vasopressin Play a Role in the Pathogenesis of Hypertension?

1981 ◽  
Vol 61 (s7) ◽  
pp. 141s-143s ◽  
Author(s):  
P. L. Padfield ◽  
J. J. Brown ◽  
A. F. Lever ◽  
J. J. Morton ◽  
J. I. S. Robertson
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Plasma Levels ◽  
Moderate Essential Hypertension ◽  
Malignant Hypertension ◽  
Control Subjects ◽  
Vasoconstrictor Effect ◽  
Normotensive Control

1. Plasma levels of vasopressin were found to be significantly higher in 29 patients with malignant hypertension than in 106 normotensive control subjects (13 ± 2 ng/l vs 5.8 ± 0.2 ng/l, P &lt; 0.001). 2. No correlation was apparent between blood pressure and circulating vasopressin. 3. An acute, incremental infusion of vasopressin (0.125, 0.25 and 0.5 ng min−1 kg−1) in nine patients with mild-moderate essential hypertension produced only minor changes in blood pressure despite achieving plasma levels spanning those seen in malignant hypertension. 4. Despite a small increase in pressor sensitivity to vasopressin in hypertensive subjects it is thus unlikely that an acute vasoconstrictor effect of this peptide is important in the pathogenesis of malignant hypertension.

scholarly journals Streptokinase and serum enzyme activity in myocardial infarction.

BMJ ◽  
1977 ◽  
Vol 1 (6067) ◽  
pp. 1005-1005 ◽  
Author(s):  
F Praetorius
Keyword(s):  
Myocardial Infarction ◽  
Enzyme Activity ◽  
Serum Enzyme ◽  
Serum Enzyme Activity

scholarly journals Anti-diabetic properties of root extracts of Ruellia tuberosa L: effects on serum enzyme activity

2019 ◽  
Vol 1374 ◽  
pp. 012030 ◽  
Author(s):  
A Safitri ◽  
A Roosdiana ◽  
N Arrochmah ◽  
S S Nur’Adya
Keyword(s):  
Enzyme Activity ◽  
Serum Enzyme ◽  
Serum Enzyme Activity ◽  
Root Extracts

Relationship between Serum Enzyme Activity in Acute Myocardial Infarction and Morbidity during a 2-Year Follow-Up

Cardiology ◽  
1986 ◽  
Vol 73 (2) ◽  
pp. 85-93 ◽  
Author(s):  
J. Herlitz ◽  
I. Helgesson ◽  
B.M. Hjalmarson ◽  
&Aring;. Hjalmarson ◽  
C. Jonsteg ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Enzyme Activity ◽  
Serum Enzyme ◽  
Serum Enzyme Activity

Prognosis in Patients with ST-T Changes but No Rise in Serum Enzyme Activity as Compared with Non-Q-Wave Infarction

Cardiology ◽  
1991 ◽  
Vol 79 (4) ◽  
pp. 271-279 ◽  
Author(s):  
Bj&ouml;rn W. Karlson ◽  
Johan Herlitz ◽  
Arina Richter ◽  
Magareta Sj&ouml;lin ◽  
&Aring;ke Hjalmarson
Keyword(s):  
Enzyme Activity ◽  
Serum Enzyme ◽  
Serum Enzyme Activity ◽  
Q Wave

Comparison of serum enzyme activity in great sturgeon, Huso huso, cultured in brackish and freshwater earth ponds in Iran

2009 ◽  
Vol 19 (3) ◽  
pp. 301-305 ◽  
Author(s):  
Farhad Rajabipour ◽  
Davar Shahsavani ◽  
Ali Moghimi ◽  
Shahla Jamili ◽  
Nassrin Mashaii
Keyword(s):  
Enzyme Activity ◽  
Huso Huso ◽  
Great Sturgeon ◽  
Serum Enzyme ◽  
Serum Enzyme Activity

Significance of Increase in Labelled Albumin Disappearance Rate in Arterial Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 211s-213s
Author(s):  
M. Ulrych ◽  
Z. Ulrych
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Volume ◽  
Plasma Renin ◽  
Disappearance Rate ◽  
Reference Standard ◽  
Hypertensive Patients ◽  
Volume Blood ◽  
Normotensive Subjects ◽  
Normotensive Control

1. Relationships between labelled albumin disappearance rate (LADR), plasma volume, blood volume, plasma renin activity (PRA) and blood pressure (BP) were studied in normotensive control subjects and patients with hypertension of different aetiology and severity. In essential hypertensive patients without complications an inverse linear relationship was found between blood pressure and plasma or blood volume. 2. Very close inverse correlations were found between LADR and PRA in both normotensive subjects and patients with uncomplicated essential hypertension. LADR appears to be an excellent reference standard for PRA. 3. It is postulated that LADR mainly reflects the relation between circulating fluid and vascular capacitance tone. LADR is increased in hypertension and blood volume may still be inappropriately high.

Sign in / Sign up

Export Citation Format

Share Document