The Role of the Central Nervous System and the Renin Angiotensin System in Renovascular Hypertension in the Rat

1977 ◽  
Vol 52 (2) ◽  
pp. 6P-6P ◽  
Author(s):  
H. J. Dargie ◽  
J. L. Reid
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Renovascular Hypertension ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
The Central Nervous System

scholarly journals Editorial: The Role of the Renin-Angiotensin System in the Central Nervous System

2021 ◽  
Vol 15 ◽  
Author(s):  
Natalia P. Rocha ◽  
Ana Cristina Simões e Silva ◽  
Antonio Lucio Teixeira
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
The Central Nervous System

scholarly journals Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system

2009 ◽  
Vol 106 (35) ◽  
pp. 14942-14947 ◽  
Author(s):  
J. Stegbauer ◽  
D.-H. Lee ◽  
S. Seubert ◽  
G. Ellrichmann ◽  
A. Manzel ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Autoimmune Inflammation ◽  
The Central Nervous System

Reversal of renovascular hypertension: role of the renal medulla

1987 ◽  
Vol 65 (8) ◽  
pp. 1566-1571 ◽  
Author(s):  
J. D. Swales ◽  
R. F. Bing ◽  
M. E. Edmunds ◽  
G. I. Russell ◽  
H. Thurston
Keyword(s):  
Blood Pressure ◽  
Renovascular Hypertension ◽  
Peripheral Resistance ◽  
Renin Angiotensin System ◽  
Renal Medulla ◽  
Pressure Control ◽  
Sodium Retention ◽  
Angiotensin System ◽  
Renin Angiotensin

The fall in blood pressure, which occurs when renovascular hypertension is corrected surgically, offers a means of elucidating the factors responsible for blood pressure control. When Goldblatt two-kidney, one-clip hypertension in the rat is reversed by unclipping the renal artery, or by removal of the ischaemic kidney, restoration of normal blood pressure is due to a fall in peripheral resistance. This is associated with sodium retention and cannot be modified by inhibition of the renin–angiotensin system. The fall is, however, partially inhibited by chemical removal of the renal medulla by means of 2-bromo-ethylamine hydrobromide. When normal rats are chemically medullectomized, moderate hypertension is produced, which cannot be attributed to the renin–angiotensin system or sodium retention. It is concluded that a renomedullary vasodepressor system is ablated by chemical medullectomy: further, this system plays a role in the surgical correction of Goldblatt hypertension.

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