Thyroid and Cardiac Effects of Timolol in the Treatment of Hyperthyroidism

1982 ◽  
Vol 63 (3) ◽  
pp. 10P-11P ◽  
Author(s):  
F. Creagh ◽  
J. Lazarus ◽  
E. Griffiths ◽  
S. Kadury
Keyword(s):  
Cardiac Effects

scholarly journals Cardiac effects of activation of the parasympathetic ganglia in the third fat pad in dog hearts.

1999 ◽  
Vol 79 ◽  
pp. 100
Author(s):  
Tsuboi Masato ◽  
Furukawa Yasuyuki ◽  
Koichi Nakajima ◽  
Fumio Kurogouchi ◽  
Chiba Shigetoshi
Keyword(s):  
Fat Pad ◽  
Cardiac Effects ◽  
Parasympathetic Ganglia ◽  
The Third

scholarly journals Possible complication of bee stings and a review of the cardiac effects of bee stings

2016 ◽  
pp. bcr2015213974 ◽  
Author(s):  
Prabha Nini Gupta ◽  
B Krishna Kumar ◽  
Praveen Velappan ◽  
M D Sudheer
Keyword(s):  
Cardiac Effects

scholarly journals Differences in Cardiac Effects of Venoms from Tentacles and the Bell of Live Carukia barnesi: Using Non-Invasive Pulse Wave Doppler

Toxins ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 19
Author(s):  
Mark Little ◽  
Peter Pereira ◽  
Jamie Seymour
Keyword(s):  
Animal Models ◽  
Murine Model ◽  
Real World ◽  
Cardiac Dysfunction ◽  
Pulse Wave ◽  
Cardiac Effects ◽  
Post Exposure ◽  
Non Invasive ◽  
Cardiac Decompensation

Carukia barnesi was the first in an expanding list of cubozoan jellyfish whose sting was identified as causing Irukandji syndrome. Nematocysts present on both the bell and tentacles are known to produce localised stings, though their individual roles in Irukandji syndrome have remained speculative. This research examines differences through venom profiling and pulse wave Doppler in a murine model. The latter demonstrates marked measurable differences in cardiac parameters. The venom from tentacles (CBVt) resulted in cardiac decompensation and death in all mice at a mean of 40 min (95% CL: ± 11 min), whereas the venom from the bell (CBVb) did not produce any cardiac dysfunction nor death in mice at 60 min post-exposure. This difference is pronounced, and we propose that bell exposure is unlikely to be causative in severe Irukandji syndrome. To date, all previously published cubozoan venom research utilised parenterally administered venom in their animal models, with many acknowledging their questionable applicability to real-world envenomation. Our model used live cubozoans on anaesthetised mice to simulate normal envenomation mechanics and actual expressed venoms. Consequently, we provide validity to the parenteral methodology used by previous cubozoan venom research.

scholarly journals The dependence of the cardiac effects of nifedipine on the responses of the peripheral vascular system.

Circulation ◽  
1984 ◽  
Vol 69 (5) ◽  
pp. 963-972 ◽  
Author(s):  
P B Kurnik ◽  
A J Tiefenbrunn ◽  
P A Ludbrook
Keyword(s):  
Vascular System ◽  
Peripheral Vascular ◽  
Cardiac Effects

Inhibitory 5-HT receptors involved in sympathetic pressor and cardiac effects

1995 ◽  
Vol 31 ◽  
pp. 189
Author(s):  
C. Velasco ◽  
A. Morán ◽  
E. Martín ◽  
M.L. Martín ◽  
L. San Román
Keyword(s):  
Cardiac Effects

scholarly journals Coronary vasodilation and positive inotropism by urocortin in the isolated rat heart

2001 ◽  
Vol 169 (1) ◽  
pp. 177-183 ◽  
Author(s):  
K Terui ◽  
A Higashiyama ◽  
N Horiba ◽  
KI Furukawa ◽  
S Motomura ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Coronary Vasodilation ◽  
Duration Of Action ◽  
Inotropic Effects ◽  
Vasodilator Effect ◽  
Cardiac Effects ◽  
Positive Inotropic Effects ◽  
Isolated Rat

Corticotropin-releasing factor (CRF) has a coronary vasodilator effect and a positive inotropic effect on the isolated rat heart. Recently, expression of CRF receptor type 2 (CRF-R2) has been demonstrated in the heart. In addition, urocortin (Ucn), a new member of the CRF family, has been reported to have much greater affinity for CRF-R2 than CRF. It is suggested that the cardiac effects of Ucn may be more potent than those of CRF. We compared the effect of Ucn with that of CRF on isolated rat heart. The effects of Ucn were then analyzed to determine whether these effects were mediated by CRF receptors and/or any other mediators under the following conditions: perfusion buffer containing (1) alpha-helical CRF 9-41, (2) indomethacin, (3) N(G)-nitro-l -arginine methylester and (4) propranolol. Ucn exhibited a greater effect with a longer duration of action than CRF. Indomethacin significantly attenuated the vasodilator effects of Ucn (P<0.05). CRF receptor antagonist diminished both coronary vasodilation and the positive inotropic effects of Ucn (P<0.05). These results suggest that the cardiac effects of Ucn may be mediated by a CRF receptor, and prostaglandins may be involved in the vasodilator effect.

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